Adult Stromal (Skeletal, Mesenchymal) Stem Cells: Advances Towards Clinical Applications

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Mesenchymal Stem Cells (MSC) are non-hematopoietic adult stromal cells that reside in a perivascular niche in close association with pericytes and endothelial cells and possess self-renewal and multi-lineage differentiation capacity. The origin, unique properties, and therapeutic benefits of MSC are under intensive investigation worldwide. Several challenges with regard to the proper source of clinical-grade MSC and the efficacy of MSC-based treatment strategies need to be addressed before MSC can be routinely used in the clinic. Here, we discuss three areas that can potentially facilitate the translation of MSC into clinic: Generation of MSC-like cells from human pluripotent stem cells, strategies to enhance homing of MSC to injured tissues, and targeting of MSC in vivo.
Original languageEnglish
Title of host publicationAdult Stem Cells : Stem Cell Biology and Regenerative Medicine
EditorsKursad Turksen
Number of pages15
Place of PublicationNew York
PublisherHumana Press
Publication date2014
ISBN (Print)978-1-4614-9568-0
ISBN (Electronic)978-1-4614-9569-7
Publication statusPublished - 2014

ID: 138176649