Advanced paternal age and childhood cancer in offspring: A nationwide register-based cohort study

Research output: Contribution to journalJournal articleResearchpeer-review

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Advanced paternal age and childhood cancer in offspring : A nationwide register-based cohort study. / Urhøj, Stine Kjær; Raaschou-Nielsen, Ole; Hansen, Anne Vinkel; Mortensen, Laust Hvas; Andersen, Per Kragh; Nybo Andersen, Anne-Marie.

In: International Journal of Cancer, Vol. 140, No. 11, 01.06.2017, p. 2461-2472.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Urhøj, SK, Raaschou-Nielsen, O, Hansen, AV, Mortensen, LH, Andersen, PK & Nybo Andersen, A-M 2017, 'Advanced paternal age and childhood cancer in offspring: A nationwide register-based cohort study', International Journal of Cancer, vol. 140, no. 11, pp. 2461-2472. https://doi.org/10.1002/ijc.30677

APA

Urhøj, S. K., Raaschou-Nielsen, O., Hansen, A. V., Mortensen, L. H., Andersen, P. K., & Nybo Andersen, A-M. (2017). Advanced paternal age and childhood cancer in offspring: A nationwide register-based cohort study. International Journal of Cancer, 140(11), 2461-2472. https://doi.org/10.1002/ijc.30677

Vancouver

Urhøj SK, Raaschou-Nielsen O, Hansen AV, Mortensen LH, Andersen PK, Nybo Andersen A-M. Advanced paternal age and childhood cancer in offspring: A nationwide register-based cohort study. International Journal of Cancer. 2017 Jun 1;140(11):2461-2472. https://doi.org/10.1002/ijc.30677

Author

Urhøj, Stine Kjær ; Raaschou-Nielsen, Ole ; Hansen, Anne Vinkel ; Mortensen, Laust Hvas ; Andersen, Per Kragh ; Nybo Andersen, Anne-Marie. / Advanced paternal age and childhood cancer in offspring : A nationwide register-based cohort study. In: International Journal of Cancer. 2017 ; Vol. 140, No. 11. pp. 2461-2472.

Bibtex

@article{fc77ee60eccc45cf84d1a0d3bdadfdc7,
title = "Advanced paternal age and childhood cancer in offspring: A nationwide register-based cohort study",
abstract = "Cancer initiation is presumed to occur in utero for many childhood cancers and it has been hypothesized that advanced paternal age may have an impact due to the increasing number of mutations in the sperm DNA with increasing paternal age. We examined the association between paternal age and specific types of childhood cancer in offspring in a large nationwide cohort of 1,904,363 children born in Denmark from 1978 through 2010. The children were identified in the Danish Medical Birth Registry and were linked to information from other national registers, including the Danish Cancer Registry. In total, 3,492 children were diagnosed with cancer before the age of 15 years. The adjusted hazard ratio of childhood cancer according to paternal age was estimated using Cox proportional hazards regressions. We found a 13{\%} (95{\%} confidence interval: 4–23{\%}) higher hazard rate for every 5 years advantage in paternal age for acute lymphoblastic leukemia, while no clear association was found for acute myeloid leukemia (hazard ratio pr. 5 years = 1.02, 95{\%} confidence interval: 0.80–1.30). The estimates for neoplasms in the central nervous system suggested a lower hazard rate with higher paternal age (hazard ratio pr. 5 years = 0.92, 95{\%} confidence interval: 0.84–1.01). No clear associations were found for the remaining childhood cancer types. The findings suggest that paternal age is moderately associated with a higher rate of childhood acute lymphoblastic leukemia, but not acute myeloid leukemia, in offspring, while no firm conclusions could be made for other specific cancer types.",
author = "Urh{\o}j, {Stine Kj{\ae}r} and Ole Raaschou-Nielsen and Hansen, {Anne Vinkel} and Mortensen, {Laust Hvas} and Andersen, {Per Kragh} and {Nybo Andersen}, Anne-Marie",
year = "2017",
month = "6",
day = "1",
doi = "10.1002/ijc.30677",
language = "English",
volume = "140",
pages = "2461--2472",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "JohnWiley & Sons, Inc.",
number = "11",

}

RIS

TY - JOUR

T1 - Advanced paternal age and childhood cancer in offspring

T2 - A nationwide register-based cohort study

AU - Urhøj, Stine Kjær

AU - Raaschou-Nielsen, Ole

AU - Hansen, Anne Vinkel

AU - Mortensen, Laust Hvas

AU - Andersen, Per Kragh

AU - Nybo Andersen, Anne-Marie

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Cancer initiation is presumed to occur in utero for many childhood cancers and it has been hypothesized that advanced paternal age may have an impact due to the increasing number of mutations in the sperm DNA with increasing paternal age. We examined the association between paternal age and specific types of childhood cancer in offspring in a large nationwide cohort of 1,904,363 children born in Denmark from 1978 through 2010. The children were identified in the Danish Medical Birth Registry and were linked to information from other national registers, including the Danish Cancer Registry. In total, 3,492 children were diagnosed with cancer before the age of 15 years. The adjusted hazard ratio of childhood cancer according to paternal age was estimated using Cox proportional hazards regressions. We found a 13% (95% confidence interval: 4–23%) higher hazard rate for every 5 years advantage in paternal age for acute lymphoblastic leukemia, while no clear association was found for acute myeloid leukemia (hazard ratio pr. 5 years = 1.02, 95% confidence interval: 0.80–1.30). The estimates for neoplasms in the central nervous system suggested a lower hazard rate with higher paternal age (hazard ratio pr. 5 years = 0.92, 95% confidence interval: 0.84–1.01). No clear associations were found for the remaining childhood cancer types. The findings suggest that paternal age is moderately associated with a higher rate of childhood acute lymphoblastic leukemia, but not acute myeloid leukemia, in offspring, while no firm conclusions could be made for other specific cancer types.

AB - Cancer initiation is presumed to occur in utero for many childhood cancers and it has been hypothesized that advanced paternal age may have an impact due to the increasing number of mutations in the sperm DNA with increasing paternal age. We examined the association between paternal age and specific types of childhood cancer in offspring in a large nationwide cohort of 1,904,363 children born in Denmark from 1978 through 2010. The children were identified in the Danish Medical Birth Registry and were linked to information from other national registers, including the Danish Cancer Registry. In total, 3,492 children were diagnosed with cancer before the age of 15 years. The adjusted hazard ratio of childhood cancer according to paternal age was estimated using Cox proportional hazards regressions. We found a 13% (95% confidence interval: 4–23%) higher hazard rate for every 5 years advantage in paternal age for acute lymphoblastic leukemia, while no clear association was found for acute myeloid leukemia (hazard ratio pr. 5 years = 1.02, 95% confidence interval: 0.80–1.30). The estimates for neoplasms in the central nervous system suggested a lower hazard rate with higher paternal age (hazard ratio pr. 5 years = 0.92, 95% confidence interval: 0.84–1.01). No clear associations were found for the remaining childhood cancer types. The findings suggest that paternal age is moderately associated with a higher rate of childhood acute lymphoblastic leukemia, but not acute myeloid leukemia, in offspring, while no firm conclusions could be made for other specific cancer types.

U2 - 10.1002/ijc.30677

DO - 10.1002/ijc.30677

M3 - Journal article

C2 - 28257590

VL - 140

SP - 2461

EP - 2472

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 11

ER -

ID: 179322105