Advanced paternal age and stillbirth rate: a nationwide register-based cohort study of 944,031 pregnancies in Denmark

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Advanced paternal age and stillbirth rate : a nationwide register-based cohort study of 944,031 pregnancies in Denmark. / Urhøj, Stine Kjær; Andersen, Per Kragh; Mortensen, Laust Hvas; Smith, George Davey; Nybo Andersen, Anne-Marie.

In: European Journal of Epidemiology, Vol. 32, No. 3, 03.2017, p. 227-234.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Urhøj, SK, Andersen, PK, Mortensen, LH, Smith, GD & Nybo Andersen, A-M 2017, 'Advanced paternal age and stillbirth rate: a nationwide register-based cohort study of 944,031 pregnancies in Denmark', European Journal of Epidemiology, vol. 32, no. 3, pp. 227-234. https://doi.org/10.1007/s10654-017-0237-z

APA

Urhøj, S. K., Andersen, P. K., Mortensen, L. H., Smith, G. D., & Nybo Andersen, A-M. (2017). Advanced paternal age and stillbirth rate: a nationwide register-based cohort study of 944,031 pregnancies in Denmark. European Journal of Epidemiology, 32(3), 227-234. https://doi.org/10.1007/s10654-017-0237-z

Vancouver

Urhøj SK, Andersen PK, Mortensen LH, Smith GD, Nybo Andersen A-M. Advanced paternal age and stillbirth rate: a nationwide register-based cohort study of 944,031 pregnancies in Denmark. European Journal of Epidemiology. 2017 Mar;32(3):227-234. https://doi.org/10.1007/s10654-017-0237-z

Author

Urhøj, Stine Kjær ; Andersen, Per Kragh ; Mortensen, Laust Hvas ; Smith, George Davey ; Nybo Andersen, Anne-Marie. / Advanced paternal age and stillbirth rate : a nationwide register-based cohort study of 944,031 pregnancies in Denmark. In: European Journal of Epidemiology. 2017 ; Vol. 32, No. 3. pp. 227-234.

Bibtex

@article{476ba243991b4a4a980a751a2b3da424,
title = "Advanced paternal age and stillbirth rate: a nationwide register-based cohort study of 944,031 pregnancies in Denmark",
abstract = "Advanced paternal age has been associated with a variety of rare conditions and diseases of great public health impact. An increased number of de novo point mutations in sperm with increasing age have been suggested as a mechanism, which would likely also affect fetal viability. We examined the association between paternal age and stillbirth rate in a large nationwide cohort. We identified all pregnancies in Denmark from 1994 to 2010 carried to a gestational age of at least 22 completed weeks (n = 944,031) as registered in national registers and linked to individual register data about the parents. The hazard ratio of stillbirth according to paternal age was estimated, adjusted for maternal age in 1-year categories, year of outcome, and additionally parental educational levels. The relative rate of stillbirth (n = 4946) according to paternal age was found to be J-shaped with the highest hazard ratio for fathers aged more than 40 years when paternal age was modelled using restricted cubic splines. When modelled categorically, the adjusted hazard ratios of stillbirth were as follows: <25, 1.16 (95{\%} confidence interval, CI 1.01–1.34); 25–29, 1.03 (95{\%} CI 0.95–1.11); 35–39, 1.16 (95{\%} CI 1.07–1.26); 40–44, 1.41 (95{\%} CI 1.26–1.59); 45–49, 1.20 (95{\%} CI 0.97–1.49); 50+, 1.58 (95{\%} CI 1.18–2.11), compared with fathers aged 30–34 years. These estimates attenuated slightly when further adjusted for parental education. Our study showed that paternal age was associated with the relative rate of stillbirth in a J-shaped manner with the highest hazard ratios among fathers aged more than 40 years.",
author = "Urh{\o}j, {Stine Kj{\ae}r} and Andersen, {Per Kragh} and Mortensen, {Laust Hvas} and Smith, {George Davey} and {Nybo Andersen}, Anne-Marie",
year = "2017",
month = "3",
doi = "10.1007/s10654-017-0237-z",
language = "English",
volume = "32",
pages = "227--234",
journal = "European Journal of Epidemiology",
issn = "0393-2990",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Advanced paternal age and stillbirth rate

T2 - a nationwide register-based cohort study of 944,031 pregnancies in Denmark

AU - Urhøj, Stine Kjær

AU - Andersen, Per Kragh

AU - Mortensen, Laust Hvas

AU - Smith, George Davey

AU - Nybo Andersen, Anne-Marie

PY - 2017/3

Y1 - 2017/3

N2 - Advanced paternal age has been associated with a variety of rare conditions and diseases of great public health impact. An increased number of de novo point mutations in sperm with increasing age have been suggested as a mechanism, which would likely also affect fetal viability. We examined the association between paternal age and stillbirth rate in a large nationwide cohort. We identified all pregnancies in Denmark from 1994 to 2010 carried to a gestational age of at least 22 completed weeks (n = 944,031) as registered in national registers and linked to individual register data about the parents. The hazard ratio of stillbirth according to paternal age was estimated, adjusted for maternal age in 1-year categories, year of outcome, and additionally parental educational levels. The relative rate of stillbirth (n = 4946) according to paternal age was found to be J-shaped with the highest hazard ratio for fathers aged more than 40 years when paternal age was modelled using restricted cubic splines. When modelled categorically, the adjusted hazard ratios of stillbirth were as follows: <25, 1.16 (95% confidence interval, CI 1.01–1.34); 25–29, 1.03 (95% CI 0.95–1.11); 35–39, 1.16 (95% CI 1.07–1.26); 40–44, 1.41 (95% CI 1.26–1.59); 45–49, 1.20 (95% CI 0.97–1.49); 50+, 1.58 (95% CI 1.18–2.11), compared with fathers aged 30–34 years. These estimates attenuated slightly when further adjusted for parental education. Our study showed that paternal age was associated with the relative rate of stillbirth in a J-shaped manner with the highest hazard ratios among fathers aged more than 40 years.

AB - Advanced paternal age has been associated with a variety of rare conditions and diseases of great public health impact. An increased number of de novo point mutations in sperm with increasing age have been suggested as a mechanism, which would likely also affect fetal viability. We examined the association between paternal age and stillbirth rate in a large nationwide cohort. We identified all pregnancies in Denmark from 1994 to 2010 carried to a gestational age of at least 22 completed weeks (n = 944,031) as registered in national registers and linked to individual register data about the parents. The hazard ratio of stillbirth according to paternal age was estimated, adjusted for maternal age in 1-year categories, year of outcome, and additionally parental educational levels. The relative rate of stillbirth (n = 4946) according to paternal age was found to be J-shaped with the highest hazard ratio for fathers aged more than 40 years when paternal age was modelled using restricted cubic splines. When modelled categorically, the adjusted hazard ratios of stillbirth were as follows: <25, 1.16 (95% confidence interval, CI 1.01–1.34); 25–29, 1.03 (95% CI 0.95–1.11); 35–39, 1.16 (95% CI 1.07–1.26); 40–44, 1.41 (95% CI 1.26–1.59); 45–49, 1.20 (95% CI 0.97–1.49); 50+, 1.58 (95% CI 1.18–2.11), compared with fathers aged 30–34 years. These estimates attenuated slightly when further adjusted for parental education. Our study showed that paternal age was associated with the relative rate of stillbirth in a J-shaped manner with the highest hazard ratios among fathers aged more than 40 years.

U2 - 10.1007/s10654-017-0237-z

DO - 10.1007/s10654-017-0237-z

M3 - Journal article

C2 - 28271174

VL - 32

SP - 227

EP - 234

JO - European Journal of Epidemiology

JF - European Journal of Epidemiology

SN - 0393-2990

IS - 3

ER -

ID: 179322188