Aerobic exercise reduces biomarkers related to cardiovascular risk among cleaners: effects of a worksite intervention RCT

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Aerobic exercise reduces biomarkers related to cardiovascular risk among cleaners : effects of a worksite intervention RCT. / Korshøj, Mette; Ravn, Marie Højbjerg; Holtermann, Andreas; Hansen, Åse Marie; Krustrup, Peter.

In: International Archives of Occupational and Environmental Health, Vol. 89, No. 2, 2016, p. 239-249.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Korshøj, M, Ravn, MH, Holtermann, A, Hansen, ÅM & Krustrup, P 2016, 'Aerobic exercise reduces biomarkers related to cardiovascular risk among cleaners: effects of a worksite intervention RCT', International Archives of Occupational and Environmental Health, vol. 89, no. 2, pp. 239-249. https://doi.org/10.1007/s00420-015-1067-5

APA

Korshøj, M., Ravn, M. H., Holtermann, A., Hansen, Å. M., & Krustrup, P. (2016). Aerobic exercise reduces biomarkers related to cardiovascular risk among cleaners: effects of a worksite intervention RCT. International Archives of Occupational and Environmental Health, 89(2), 239-249. https://doi.org/10.1007/s00420-015-1067-5

Vancouver

Korshøj M, Ravn MH, Holtermann A, Hansen ÅM, Krustrup P. Aerobic exercise reduces biomarkers related to cardiovascular risk among cleaners: effects of a worksite intervention RCT. International Archives of Occupational and Environmental Health. 2016;89(2):239-249. https://doi.org/10.1007/s00420-015-1067-5

Author

Korshøj, Mette ; Ravn, Marie Højbjerg ; Holtermann, Andreas ; Hansen, Åse Marie ; Krustrup, Peter. / Aerobic exercise reduces biomarkers related to cardiovascular risk among cleaners : effects of a worksite intervention RCT. In: International Archives of Occupational and Environmental Health. 2016 ; Vol. 89, No. 2. pp. 239-249.

Bibtex

@article{46ab9fd2887a48998527d8cb2422cee0,
title = "Aerobic exercise reduces biomarkers related to cardiovascular risk among cleaners: effects of a worksite intervention RCT",
abstract = "PURPOSE: Blue-collar workers have an increased risk of cardiovascular disease. Accordingly, elevated levels of biomarkers related to risk of cardiovascular disease, such as high-sensitive C-reactive protein, have been observed among blue-collar workers. The objective was to examine whether an aerobic exercise worksite intervention changes the level of inflammation biomarkers among cleaners.METHODS: The design was a cluster-randomized controlled trial with 4-month worksite intervention. Before the 116 cleaners aged 18-65 years were randomized, they signed an informed consent form. The reference group (n = 59) received lectures, and the aerobic exercise group (n = 57) performed worksite aerobic exercise (30 min twice a week). Levels of biomarkers (high-sensitive C-reactive protein, fibrinogen, cholesterol, low- and high-density lipoprotein cholesterol and triglyceride) were collected at baseline and after 4 months. A repeated-measure, multi-adjusted, mixed-model intention-to-treat analysis was applied to compare between-group differences. The study was registered as ISRCTN86682076.RESULTS: Significant (p < 0.05) between-group reductions from baseline to follow-up were found for high-sensitive C-reactive protein (-0.54 ± 0.20 µg/ml; 95 {\%} CI -0.94, -0.14), low-density lipoprotein cholesterol (-0.32 ± 0.11 mmol/L; 95 {\%} CI -0.54, -0.10) and the ratios of LDL/HDL (-0.30 ± 0.08; 95 {\%} CI -0.46, -0.14), and LDL/TC cholesterol (-0.04 ± 0.02; 95 {\%} CI -0.07, -0.01).CONCLUSION: This study indicates that an aerobic exercise intervention among cleaners leads to reduced levels of high-sensitive C-reactive protein and low-density lipoprotein cholesterol, and an unaltered level of fibrinogen. The aerobic exercise seems to improve inflammatory levels and lipoprotein profile among cleaners, with no signs of cardiovascular overload.",
author = "Mette Korsh{\o}j and Ravn, {Marie H{\o}jbjerg} and Andreas Holtermann and Hansen, {{\AA}se Marie} and Peter Krustrup",
note = "CURIS 2016 NEXS 034",
year = "2016",
doi = "10.1007/s00420-015-1067-5",
language = "English",
volume = "89",
pages = "239--249",
journal = "International Archives of Occupational and Environmental Health",
issn = "0340-0131",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Aerobic exercise reduces biomarkers related to cardiovascular risk among cleaners

T2 - effects of a worksite intervention RCT

AU - Korshøj, Mette

AU - Ravn, Marie Højbjerg

AU - Holtermann, Andreas

AU - Hansen, Åse Marie

AU - Krustrup, Peter

N1 - CURIS 2016 NEXS 034

PY - 2016

Y1 - 2016

N2 - PURPOSE: Blue-collar workers have an increased risk of cardiovascular disease. Accordingly, elevated levels of biomarkers related to risk of cardiovascular disease, such as high-sensitive C-reactive protein, have been observed among blue-collar workers. The objective was to examine whether an aerobic exercise worksite intervention changes the level of inflammation biomarkers among cleaners.METHODS: The design was a cluster-randomized controlled trial with 4-month worksite intervention. Before the 116 cleaners aged 18-65 years were randomized, they signed an informed consent form. The reference group (n = 59) received lectures, and the aerobic exercise group (n = 57) performed worksite aerobic exercise (30 min twice a week). Levels of biomarkers (high-sensitive C-reactive protein, fibrinogen, cholesterol, low- and high-density lipoprotein cholesterol and triglyceride) were collected at baseline and after 4 months. A repeated-measure, multi-adjusted, mixed-model intention-to-treat analysis was applied to compare between-group differences. The study was registered as ISRCTN86682076.RESULTS: Significant (p < 0.05) between-group reductions from baseline to follow-up were found for high-sensitive C-reactive protein (-0.54 ± 0.20 µg/ml; 95 % CI -0.94, -0.14), low-density lipoprotein cholesterol (-0.32 ± 0.11 mmol/L; 95 % CI -0.54, -0.10) and the ratios of LDL/HDL (-0.30 ± 0.08; 95 % CI -0.46, -0.14), and LDL/TC cholesterol (-0.04 ± 0.02; 95 % CI -0.07, -0.01).CONCLUSION: This study indicates that an aerobic exercise intervention among cleaners leads to reduced levels of high-sensitive C-reactive protein and low-density lipoprotein cholesterol, and an unaltered level of fibrinogen. The aerobic exercise seems to improve inflammatory levels and lipoprotein profile among cleaners, with no signs of cardiovascular overload.

AB - PURPOSE: Blue-collar workers have an increased risk of cardiovascular disease. Accordingly, elevated levels of biomarkers related to risk of cardiovascular disease, such as high-sensitive C-reactive protein, have been observed among blue-collar workers. The objective was to examine whether an aerobic exercise worksite intervention changes the level of inflammation biomarkers among cleaners.METHODS: The design was a cluster-randomized controlled trial with 4-month worksite intervention. Before the 116 cleaners aged 18-65 years were randomized, they signed an informed consent form. The reference group (n = 59) received lectures, and the aerobic exercise group (n = 57) performed worksite aerobic exercise (30 min twice a week). Levels of biomarkers (high-sensitive C-reactive protein, fibrinogen, cholesterol, low- and high-density lipoprotein cholesterol and triglyceride) were collected at baseline and after 4 months. A repeated-measure, multi-adjusted, mixed-model intention-to-treat analysis was applied to compare between-group differences. The study was registered as ISRCTN86682076.RESULTS: Significant (p < 0.05) between-group reductions from baseline to follow-up were found for high-sensitive C-reactive protein (-0.54 ± 0.20 µg/ml; 95 % CI -0.94, -0.14), low-density lipoprotein cholesterol (-0.32 ± 0.11 mmol/L; 95 % CI -0.54, -0.10) and the ratios of LDL/HDL (-0.30 ± 0.08; 95 % CI -0.46, -0.14), and LDL/TC cholesterol (-0.04 ± 0.02; 95 % CI -0.07, -0.01).CONCLUSION: This study indicates that an aerobic exercise intervention among cleaners leads to reduced levels of high-sensitive C-reactive protein and low-density lipoprotein cholesterol, and an unaltered level of fibrinogen. The aerobic exercise seems to improve inflammatory levels and lipoprotein profile among cleaners, with no signs of cardiovascular overload.

U2 - 10.1007/s00420-015-1067-5

DO - 10.1007/s00420-015-1067-5

M3 - Journal article

VL - 89

SP - 239

EP - 249

JO - International Archives of Occupational and Environmental Health

JF - International Archives of Occupational and Environmental Health

SN - 0340-0131

IS - 2

ER -

ID: 141011789