Aging and oxidatively damaged nuclear DNA in animal organs

Research output: Contribution to journalJournal articlepeer-review

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Aging and oxidatively damaged nuclear DNA in animal organs. / Møller, Peter; Løhr, Mille; Folkmann, Janne K; Mikkelsen, Lone; Loft, Steffen.

In: Free Radical Biology & Medicine, Vol. 48, No. 10, 2010, p. 1275-85.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Møller, P, Løhr, M, Folkmann, JK, Mikkelsen, L & Loft, S 2010, 'Aging and oxidatively damaged nuclear DNA in animal organs', Free Radical Biology & Medicine, vol. 48, no. 10, pp. 1275-85. https://doi.org/10.1016/j.freeradbiomed.2010.02.003

APA

Møller, P., Løhr, M., Folkmann, J. K., Mikkelsen, L., & Loft, S. (2010). Aging and oxidatively damaged nuclear DNA in animal organs. Free Radical Biology & Medicine, 48(10), 1275-85. https://doi.org/10.1016/j.freeradbiomed.2010.02.003

Vancouver

Møller P, Løhr M, Folkmann JK, Mikkelsen L, Loft S. Aging and oxidatively damaged nuclear DNA in animal organs. Free Radical Biology & Medicine. 2010;48(10):1275-85. https://doi.org/10.1016/j.freeradbiomed.2010.02.003

Author

Møller, Peter ; Løhr, Mille ; Folkmann, Janne K ; Mikkelsen, Lone ; Loft, Steffen. / Aging and oxidatively damaged nuclear DNA in animal organs. In: Free Radical Biology & Medicine. 2010 ; Vol. 48, No. 10. pp. 1275-85.

Bibtex

@article{4164f3a0e81011dfb6d2000ea68e967b,
title = "Aging and oxidatively damaged nuclear DNA in animal organs",
abstract = "Oxidative stress is considered to contribute to aging and is associated with the generation of oxidatively damaged DNA, including 8-oxo-7,8-dihydroguanine. We have identified 69 studies that have measured the level of oxidatively damaged DNA in organs of animals at various ages. In general, organs with limited cell proliferation, i.e., liver, kidney, brain, heart, pancreas, and muscle, tended to show accumulation of DNA damage with age, whereas organs with highly proliferating cells, such as intestine, spleen, and testis, showed more equivocal or no effect of age. A restricted analysis of studies reporting a baseline level of damaged DNA that was fewer than 5 lesions/10(6) dG showed that 21 of 29 studies reported age-associated accumulation of DNA damage. The standardized mean difference in oxidatively damaged DNA between the oldest and the youngest age groups was 1.49 (95% CI 1.03-1.95). There was no difference between age span, number of tested organs, statistical power, sex, strain, or breeding between the studies showing positive and null effects. Citation and publication bias seems to be a problem in the overall dataset, whereas it is less pronounced in the restricted dataset. There is compelling evidence for aging-associated accumulation of oxidatively damaged DNA in organs with limited cell proliferation.",
author = "Peter M{\o}ller and Mille L{\o}hr and Folkmann, {Janne K} and Lone Mikkelsen and Steffen Loft",
note = "Keywords: Aging; Animal Structures; Animals; Cell Nucleus; Cell Proliferation; DNA Damage; Databases as Topic; Guanine; Humans; Oxidative Stress; Publication Bias",
year = "2010",
doi = "10.1016/j.freeradbiomed.2010.02.003",
language = "English",
volume = "48",
pages = "1275--85",
journal = "Free Radical Biology & Medicine",
issn = "0891-5849",
publisher = "Elsevier",
number = "10",

}

RIS

TY - JOUR

T1 - Aging and oxidatively damaged nuclear DNA in animal organs

AU - Møller, Peter

AU - Løhr, Mille

AU - Folkmann, Janne K

AU - Mikkelsen, Lone

AU - Loft, Steffen

N1 - Keywords: Aging; Animal Structures; Animals; Cell Nucleus; Cell Proliferation; DNA Damage; Databases as Topic; Guanine; Humans; Oxidative Stress; Publication Bias

PY - 2010

Y1 - 2010

N2 - Oxidative stress is considered to contribute to aging and is associated with the generation of oxidatively damaged DNA, including 8-oxo-7,8-dihydroguanine. We have identified 69 studies that have measured the level of oxidatively damaged DNA in organs of animals at various ages. In general, organs with limited cell proliferation, i.e., liver, kidney, brain, heart, pancreas, and muscle, tended to show accumulation of DNA damage with age, whereas organs with highly proliferating cells, such as intestine, spleen, and testis, showed more equivocal or no effect of age. A restricted analysis of studies reporting a baseline level of damaged DNA that was fewer than 5 lesions/10(6) dG showed that 21 of 29 studies reported age-associated accumulation of DNA damage. The standardized mean difference in oxidatively damaged DNA between the oldest and the youngest age groups was 1.49 (95% CI 1.03-1.95). There was no difference between age span, number of tested organs, statistical power, sex, strain, or breeding between the studies showing positive and null effects. Citation and publication bias seems to be a problem in the overall dataset, whereas it is less pronounced in the restricted dataset. There is compelling evidence for aging-associated accumulation of oxidatively damaged DNA in organs with limited cell proliferation.

AB - Oxidative stress is considered to contribute to aging and is associated with the generation of oxidatively damaged DNA, including 8-oxo-7,8-dihydroguanine. We have identified 69 studies that have measured the level of oxidatively damaged DNA in organs of animals at various ages. In general, organs with limited cell proliferation, i.e., liver, kidney, brain, heart, pancreas, and muscle, tended to show accumulation of DNA damage with age, whereas organs with highly proliferating cells, such as intestine, spleen, and testis, showed more equivocal or no effect of age. A restricted analysis of studies reporting a baseline level of damaged DNA that was fewer than 5 lesions/10(6) dG showed that 21 of 29 studies reported age-associated accumulation of DNA damage. The standardized mean difference in oxidatively damaged DNA between the oldest and the youngest age groups was 1.49 (95% CI 1.03-1.95). There was no difference between age span, number of tested organs, statistical power, sex, strain, or breeding between the studies showing positive and null effects. Citation and publication bias seems to be a problem in the overall dataset, whereas it is less pronounced in the restricted dataset. There is compelling evidence for aging-associated accumulation of oxidatively damaged DNA in organs with limited cell proliferation.

U2 - 10.1016/j.freeradbiomed.2010.02.003

DO - 10.1016/j.freeradbiomed.2010.02.003

M3 - Journal article

C2 - 20149865

VL - 48

SP - 1275

EP - 1285

JO - Free Radical Biology & Medicine

JF - Free Radical Biology & Medicine

SN - 0891-5849

IS - 10

ER -

ID: 22930144