An overview of antiviral properties of bacteriophages with emphasis on the treatment of COVID-19 infection
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An overview of antiviral properties of bacteriophages with emphasis on the treatment of COVID-19 infection. / Jalili, Mahsa; Ansari, Nastaran; Pourhossein, Behzad; Fazeli, Maryam; Jalilian, Farid Azizi.
In: Infectious Disorders - Drug Targets, Vol. 22, No. 6, e240122200472, 2022.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - An overview of antiviral properties of bacteriophages with emphasis on the treatment of COVID-19 infection
AU - Jalili, Mahsa
AU - Ansari, Nastaran
AU - Pourhossein, Behzad
AU - Fazeli, Maryam
AU - Jalilian, Farid Azizi
N1 - Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
PY - 2022
Y1 - 2022
N2 - Bacteriophages or phages are the most abundant organisms in the biosphere, and they have a unique feature for prokaryotic organisms. Scientists consider phages an appropriate tool for understanding molecular biology, horizontal gene transfer vectors, and stimulants of bacterial evolution, a source of diagnostic and genetic tools and new therapeutic agents. Therefore, research into the biology of phages and their relationship to the host, as we appropriate tools as modulation of the host immune system, is a key to a better understanding of biological systems. Numerous studies confirmed that bacteriophages are a genetic tool with high potential for the treatment of infectious diseases, including bacterial, fungal, and viral infections. Therefore, phages may be used as an appropriate therapeutic target against some viruses, such as COVID-19 infection. In this study, we describe the role of phages in modulating the host immune system, the production of specific antibodies against the COVID-19 virus by the host immune system, and the minimization of damage caused by the COVID-19 virus to the host. Also, the present study expresses our understanding of the prospect of phage therapy as an adjunctive therapy.
AB - Bacteriophages or phages are the most abundant organisms in the biosphere, and they have a unique feature for prokaryotic organisms. Scientists consider phages an appropriate tool for understanding molecular biology, horizontal gene transfer vectors, and stimulants of bacterial evolution, a source of diagnostic and genetic tools and new therapeutic agents. Therefore, research into the biology of phages and their relationship to the host, as we appropriate tools as modulation of the host immune system, is a key to a better understanding of biological systems. Numerous studies confirmed that bacteriophages are a genetic tool with high potential for the treatment of infectious diseases, including bacterial, fungal, and viral infections. Therefore, phages may be used as an appropriate therapeutic target against some viruses, such as COVID-19 infection. In this study, we describe the role of phages in modulating the host immune system, the production of specific antibodies against the COVID-19 virus by the host immune system, and the minimization of damage caused by the COVID-19 virus to the host. Also, the present study expresses our understanding of the prospect of phage therapy as an adjunctive therapy.
KW - Faculty of Science
KW - Bacteriophage
KW - Bacteriophage therapy
KW - COVID-19
KW - SARS-CoV-2
KW - Phage therapy
KW - Infectious diseases
U2 - 10.2174/1871526522666220124110547
DO - 10.2174/1871526522666220124110547
M3 - Review
C2 - 35068397
VL - 22
JO - Infectious Disorders - Drug Targets
JF - Infectious Disorders - Drug Targets
SN - 1871-5265
IS - 6
M1 - e240122200472
ER -
ID: 290667036