Androgens and Psychosocial Factors Related to Sexual Dysfunctions in Premenopausal Women: 2016 ISSM Female Sexual Dysfunction Prize

Research output: Contribution to journalJournal articleResearchpeer-review

Sarah Wåhlin-Jacobsen, Ellids Kristensen, Anette Tønnes Pedersen, Nanna Cassandra Laessøe, Arieh S. Cohen, David M. Hougaard, Marika Lundqvist, Annamaria Giraldi

Introduction The female sexual response is complex and influenced by several biological, psychological, and social factors. Testosterone is believed to modulate a woman's sexual response and desire, because low levels are considered a risk factor for impaired sexual function, but previous studies have been inconclusive. Aim To investigate how androgen levels and psychosocial factors are associated with female sexual dysfunction (FSD), including hypoactive sexual desire disorder (HSDD). Methods The cross-sectional study included 428 premenopausal women 19 to 58 years old who completed a questionnaire on psychosocial factors and had blood sampled at days 6 to 10 in their menstrual cycle. Logistic regression models were built to test the association among hormone levels, psychosocial factors, and sexual end points. Main Outcome Measures Five different sexual end points were measured using the Female Sexual Function Index and the Female Sexual Distress Scale: impaired sexual function, sexual distress, FSD, low sexual desire, and HSDD. Serum levels of total and free testosterone, androstenedione, dehydroepiandrosterone sulfate, and androsterone glucuronide were analyzed using mass spectrometry. Results After adjusting for psychosocial factors, women with low sexual desire had significantly lower mean levels of free testosterone and androstenedione compared with women without low sexual desire. None of the androgens were associated with FSD in general or with HSDD in particular. Relationship duration longer than 2 years and mild depressive symptoms increased the risk of having all the sexual end points, including FSD in general and HSDD in particular in multivariate analyses. Conclusion In this large cross-sectional study, low sexual desire was significantly associated with levels of free testosterone and androstenedione, but FSD in general and HSDD in particular were not associated with androgen levels. Length of relationship and depression were associated with FSD including HSDD. Wåhlin-Jacobsen S, Kristensen E, Tønnes Pedersen A, et al. Androgens and Psychosocial Factors Related to Sexual Dysfunctions in Premenopausal Women. J Sex Med 2017;14:366–379.

Original languageEnglish
JournalJournal of Sexual Medicine
Volume14
Issue number3
Pages (from-to)366-379
Number of pages14
ISSN1743-6095
DOIs
Publication statusPublished - Mar 2017

    Research areas

  • Androgen, Androstenedione, Depression, Female, Psychosocial Factors, Sexual Desire, Sexual Distress, Sexual Function, Testosterone, Women

ID: 188357670