Antibody reactivities to glutamate-rich peptides of Plasmodium falciparum parasites in humans from areas of different malaria endemicity
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Antibody reactivities to glutamate-rich peptides of Plasmodium falciparum parasites in humans from areas of different malaria endemicity. / Jakobsen, P H; Theander, T G; Hviid, L; Morris-Jones, S; Jensen, J B; Bayoumi, R A; Greenwood, B M; Bygbjerg, I C; Heegaard, P M.
In: Acta Pathologica Microbiologica et Immunologica Scandinavica, Vol. 104, No. 10, 1996, p. 734-40.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Antibody reactivities to glutamate-rich peptides of Plasmodium falciparum parasites in humans from areas of different malaria endemicity
AU - Jakobsen, P H
AU - Theander, T G
AU - Hviid, L
AU - Morris-Jones, S
AU - Jensen, J B
AU - Bayoumi, R A
AU - Greenwood, B M
AU - Bygbjerg, I C
AU - Heegaard, P M
N1 - Keywords: Adolescent; Adult; Aged; Amino Acid Sequence; Animals; Antibodies, Protozoan; Antibody Specificity; Antigens, Protozoan; Denmark; Endemic Diseases; Female; Gambia; Glutamates; Humans; Indonesia; Longitudinal Studies; Malaria, Falciparum; Male; Middle Aged; Molecular Sequence Data; Plasmodium falciparum; Protozoan Proteins; Sudan
PY - 1996
Y1 - 1996
N2 - Synthetic P. falciparum peptides were evaluated as tools in epidemiological investigations of malaria. Plasma IgM and IgG antibody reactivities against synthetic peptides covering sequences of glutamate-rich protein (GLURP) and acidic-basic repeat antigen (ABRA) were measured by ELISA in individuals from malaria-endemic areas of Sudan, Indonesia and The Gambia to study antibody responses to these peptides in donors living in areas of different malaria endemicity. IgG and IgM reactivities to the peptides increased with malaria endemicity, although there were no differences in reactivities to the GLURP peptide between non-exposed donors and donors living in areas of low malaria endemicity. IgG reactivities to the GLURP peptide in Sudanese adults were high one month after treatment in all adults tested, while IgG reactivities to the ABRA peptide were infrequent. IgM responses to the peptides tested were shortlived in most patients. In Gambian children with malaria, IgM reactivities but not IgG antibody reactivities against the ABRA peptide were higher in those with mild malaria than in those with severe malaria. The peptides may be useful in future epidemiological studies, especially in areas of low malaria endemicity.
AB - Synthetic P. falciparum peptides were evaluated as tools in epidemiological investigations of malaria. Plasma IgM and IgG antibody reactivities against synthetic peptides covering sequences of glutamate-rich protein (GLURP) and acidic-basic repeat antigen (ABRA) were measured by ELISA in individuals from malaria-endemic areas of Sudan, Indonesia and The Gambia to study antibody responses to these peptides in donors living in areas of different malaria endemicity. IgG and IgM reactivities to the peptides increased with malaria endemicity, although there were no differences in reactivities to the GLURP peptide between non-exposed donors and donors living in areas of low malaria endemicity. IgG reactivities to the GLURP peptide in Sudanese adults were high one month after treatment in all adults tested, while IgG reactivities to the ABRA peptide were infrequent. IgM responses to the peptides tested were shortlived in most patients. In Gambian children with malaria, IgM reactivities but not IgG antibody reactivities against the ABRA peptide were higher in those with mild malaria than in those with severe malaria. The peptides may be useful in future epidemiological studies, especially in areas of low malaria endemicity.
M3 - Journal article
C2 - 8980624
VL - 104
SP - 734
EP - 740
JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
SN - 0903-4641
IS - 10
ER -
ID: 6748226