Armed conflict and population displacement as drivers of the evolution and dispersal of Mycobacterium tuberculosis

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Armed conflict and population displacement as drivers of the evolution and dispersal of Mycobacterium tuberculosis. / Eldholm, Vegard; Pettersson, John H.O.; Brynildsrud, Ola B.; Kitchen, Andrew; Rasmussen, Erik Michael; Lillebaek, Troels; Rønning, Janne O.; Crudu, Valeriu; Mengshoel, Anne Torunn; Debech, Nadia; Alfsnes, Kristian; Bohlin, Jon; Pepperell, Caitlin S.; Balloux, Francois.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, No. 48, 29.11.2016, p. 13881-13886.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Eldholm, V, Pettersson, JHO, Brynildsrud, OB, Kitchen, A, Rasmussen, EM, Lillebaek, T, Rønning, JO, Crudu, V, Mengshoel, AT, Debech, N, Alfsnes, K, Bohlin, J, Pepperell, CS & Balloux, F 2016, 'Armed conflict and population displacement as drivers of the evolution and dispersal of Mycobacterium tuberculosis', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 48, pp. 13881-13886. https://doi.org/10.1073/pnas.1611283113

APA

Eldholm, V., Pettersson, J. H. O., Brynildsrud, O. B., Kitchen, A., Rasmussen, E. M., Lillebaek, T., Rønning, J. O., Crudu, V., Mengshoel, A. T., Debech, N., Alfsnes, K., Bohlin, J., Pepperell, C. S., & Balloux, F. (2016). Armed conflict and population displacement as drivers of the evolution and dispersal of Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America, 113(48), 13881-13886. https://doi.org/10.1073/pnas.1611283113

Vancouver

Eldholm V, Pettersson JHO, Brynildsrud OB, Kitchen A, Rasmussen EM, Lillebaek T et al. Armed conflict and population displacement as drivers of the evolution and dispersal of Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 2016 Nov 29;113(48):13881-13886. https://doi.org/10.1073/pnas.1611283113

Author

Eldholm, Vegard ; Pettersson, John H.O. ; Brynildsrud, Ola B. ; Kitchen, Andrew ; Rasmussen, Erik Michael ; Lillebaek, Troels ; Rønning, Janne O. ; Crudu, Valeriu ; Mengshoel, Anne Torunn ; Debech, Nadia ; Alfsnes, Kristian ; Bohlin, Jon ; Pepperell, Caitlin S. ; Balloux, Francois. / Armed conflict and population displacement as drivers of the evolution and dispersal of Mycobacterium tuberculosis. In: Proceedings of the National Academy of Sciences of the United States of America. 2016 ; Vol. 113, No. 48. pp. 13881-13886.

Bibtex

@article{26d030a53ce64b889c147f7a50c89509,
title = "Armed conflict and population displacement as drivers of the evolution and dispersal of Mycobacterium tuberculosis",
abstract = "The {"}Beijing{"} Mycobacterium tuberculosis (Mtb) lineage 2 (L2) is spreading globally and has been associated with accelerated disease progression and increased antibiotic resistance. Here we performed a phylodynamic reconstruction of one of the L2 sublineages, the central Asian clade (CAC), which has recently spread to western Europe. We find that recent historical events have contributed to the evolution and dispersal of the CAC. Our timing estimates indicate that the clade was likely introduced to Afghanistan during the 1979-1989 Soviet-Afghan war and spread further after population displacement in the wakeof the American invasion in 2001. We also find that drug resistance mutations accumulated on a massive scale in Mtb isolates from former Soviet republics after the fall of the Soviet Union, a pattern that was not observed in CAC isolates from Afghanistan. Our results underscore the detrimental effects of political instability and population displacement on tuberculosis control and demonstrate the power of phylodynamic methods in exploring bacterial evolution in space and time.",
keywords = "Antimicrobial resistance, Evolution, Mycobacterium tuberculosis, Phylodynamic analysis, Tip-dating",
author = "Vegard Eldholm and Pettersson, {John H.O.} and Brynildsrud, {Ola B.} and Andrew Kitchen and Rasmussen, {Erik Michael} and Troels Lillebaek and R{\o}nning, {Janne O.} and Valeriu Crudu and Mengshoel, {Anne Torunn} and Nadia Debech and Kristian Alfsnes and Jon Bohlin and Pepperell, {Caitlin S.} and Francois Balloux",
year = "2016",
month = nov,
day = "29",
doi = "10.1073/pnas.1611283113",
language = "English",
volume = "113",
pages = "13881--13886",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "The National Academy of Sciences of the United States of America",
number = "48",

}

RIS

TY - JOUR

T1 - Armed conflict and population displacement as drivers of the evolution and dispersal of Mycobacterium tuberculosis

AU - Eldholm, Vegard

AU - Pettersson, John H.O.

AU - Brynildsrud, Ola B.

AU - Kitchen, Andrew

AU - Rasmussen, Erik Michael

AU - Lillebaek, Troels

AU - Rønning, Janne O.

AU - Crudu, Valeriu

AU - Mengshoel, Anne Torunn

AU - Debech, Nadia

AU - Alfsnes, Kristian

AU - Bohlin, Jon

AU - Pepperell, Caitlin S.

AU - Balloux, Francois

PY - 2016/11/29

Y1 - 2016/11/29

N2 - The "Beijing" Mycobacterium tuberculosis (Mtb) lineage 2 (L2) is spreading globally and has been associated with accelerated disease progression and increased antibiotic resistance. Here we performed a phylodynamic reconstruction of one of the L2 sublineages, the central Asian clade (CAC), which has recently spread to western Europe. We find that recent historical events have contributed to the evolution and dispersal of the CAC. Our timing estimates indicate that the clade was likely introduced to Afghanistan during the 1979-1989 Soviet-Afghan war and spread further after population displacement in the wakeof the American invasion in 2001. We also find that drug resistance mutations accumulated on a massive scale in Mtb isolates from former Soviet republics after the fall of the Soviet Union, a pattern that was not observed in CAC isolates from Afghanistan. Our results underscore the detrimental effects of political instability and population displacement on tuberculosis control and demonstrate the power of phylodynamic methods in exploring bacterial evolution in space and time.

AB - The "Beijing" Mycobacterium tuberculosis (Mtb) lineage 2 (L2) is spreading globally and has been associated with accelerated disease progression and increased antibiotic resistance. Here we performed a phylodynamic reconstruction of one of the L2 sublineages, the central Asian clade (CAC), which has recently spread to western Europe. We find that recent historical events have contributed to the evolution and dispersal of the CAC. Our timing estimates indicate that the clade was likely introduced to Afghanistan during the 1979-1989 Soviet-Afghan war and spread further after population displacement in the wakeof the American invasion in 2001. We also find that drug resistance mutations accumulated on a massive scale in Mtb isolates from former Soviet republics after the fall of the Soviet Union, a pattern that was not observed in CAC isolates from Afghanistan. Our results underscore the detrimental effects of political instability and population displacement on tuberculosis control and demonstrate the power of phylodynamic methods in exploring bacterial evolution in space and time.

KW - Antimicrobial resistance

KW - Evolution

KW - Mycobacterium tuberculosis

KW - Phylodynamic analysis

KW - Tip-dating

U2 - 10.1073/pnas.1611283113

DO - 10.1073/pnas.1611283113

M3 - Journal article

C2 - 27872285

AN - SCOPUS:84999098763

VL - 113

SP - 13881

EP - 13886

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 48

ER -

ID: 247161733