Association between prenatal exposure to analgesics and risk of schizophrenia

Research output: Contribution to journalJournal articleResearchpeer-review

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Association between prenatal exposure to analgesics and risk of schizophrenia. / Sørensen, Holger J; Mortensen, Erik Lykke; Reinisch, June M; Mednick, Sarnoff A.

In: British Journal of Psychiatry, Vol. 185, No. 185, 2004, p. 366-371.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Sørensen, HJ, Mortensen, EL, Reinisch, JM & Mednick, SA 2004, 'Association between prenatal exposure to analgesics and risk of schizophrenia', British Journal of Psychiatry, vol. 185, no. 185, pp. 366-371. https://doi.org/10.1192/bjp.185.5.366

APA

Sørensen, H. J., Mortensen, E. L., Reinisch, J. M., & Mednick, S. A. (2004). Association between prenatal exposure to analgesics and risk of schizophrenia. British Journal of Psychiatry, 185(185), 366-371. https://doi.org/10.1192/bjp.185.5.366

Vancouver

Sørensen HJ, Mortensen EL, Reinisch JM, Mednick SA. Association between prenatal exposure to analgesics and risk of schizophrenia. British Journal of Psychiatry. 2004;185(185):366-371. https://doi.org/10.1192/bjp.185.5.366

Author

Sørensen, Holger J ; Mortensen, Erik Lykke ; Reinisch, June M ; Mednick, Sarnoff A. / Association between prenatal exposure to analgesics and risk of schizophrenia. In: British Journal of Psychiatry. 2004 ; Vol. 185, No. 185. pp. 366-371.

Bibtex

@article{2cc5958074c411dbbee902004c4f4f50,
title = "Association between prenatal exposure to analgesics and risk of schizophrenia",
abstract = "BACKGROUND: Disturbances in the central nervous system originating during foetal life may increase the risk of schizophrenia. AIMS: To illuminate the hypothesis that prenatal exposure to analgesics may affect foetal neurodevelopment, leading to increased risk of schizophrenia in adulthood. METHOD: Using data from the Copenhagen Perinatal Cohort and from the Danish Psychiatric Central Register, we studied the relationship between prenatal exposure to analgesics and the risk of schizophrenia. The effect of prenatal exposure was adjusted for parental history of schizophrenia, second-trimester viral infections, concomitant drug treatment during pregnancy, an index of pregnancy complications, parental social status and parental age. RESULTS: In a risk set of 7999 individuals, 116 cases of schizophrenia were found (1.5{\%}). Prenatal exposure to analgesics in the second trimester was associated with an elevated risk (adjusted odds ratio 4.75, 95{\%} CI1.9-12.0). Independent of the covariates, the effect remained statistically significant. CONCLUSIONS: Independent of a wide range of possible confounders, a significant association between second-trimester exposure to analgesics and increased risk of schizophrenia was observed.",
author = "S{\o}rensen, {Holger J} and Mortensen, {Erik Lykke} and Reinisch, {June M} and Mednick, {Sarnoff A}",
note = "Keywords: Adult; Analgesics; Cohort Studies; Female; Humans; Male; Odds Ratio; Pregnancy; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Prenatal Exposure Delayed Effects; Risk Factors; Schizophrenia",
year = "2004",
doi = "http://dx.doi.org/10.1192/bjp.185.5.366",
language = "English",
volume = "185",
pages = "366--371",
journal = "British Journal of Psychiatry",
issn = "0007-1250",
publisher = "Royal College of Psychiatrists",
number = "185",

}

RIS

TY - JOUR

T1 - Association between prenatal exposure to analgesics and risk of schizophrenia

AU - Sørensen, Holger J

AU - Mortensen, Erik Lykke

AU - Reinisch, June M

AU - Mednick, Sarnoff A

N1 - Keywords: Adult; Analgesics; Cohort Studies; Female; Humans; Male; Odds Ratio; Pregnancy; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Prenatal Exposure Delayed Effects; Risk Factors; Schizophrenia

PY - 2004

Y1 - 2004

N2 - BACKGROUND: Disturbances in the central nervous system originating during foetal life may increase the risk of schizophrenia. AIMS: To illuminate the hypothesis that prenatal exposure to analgesics may affect foetal neurodevelopment, leading to increased risk of schizophrenia in adulthood. METHOD: Using data from the Copenhagen Perinatal Cohort and from the Danish Psychiatric Central Register, we studied the relationship between prenatal exposure to analgesics and the risk of schizophrenia. The effect of prenatal exposure was adjusted for parental history of schizophrenia, second-trimester viral infections, concomitant drug treatment during pregnancy, an index of pregnancy complications, parental social status and parental age. RESULTS: In a risk set of 7999 individuals, 116 cases of schizophrenia were found (1.5%). Prenatal exposure to analgesics in the second trimester was associated with an elevated risk (adjusted odds ratio 4.75, 95% CI1.9-12.0). Independent of the covariates, the effect remained statistically significant. CONCLUSIONS: Independent of a wide range of possible confounders, a significant association between second-trimester exposure to analgesics and increased risk of schizophrenia was observed.

AB - BACKGROUND: Disturbances in the central nervous system originating during foetal life may increase the risk of schizophrenia. AIMS: To illuminate the hypothesis that prenatal exposure to analgesics may affect foetal neurodevelopment, leading to increased risk of schizophrenia in adulthood. METHOD: Using data from the Copenhagen Perinatal Cohort and from the Danish Psychiatric Central Register, we studied the relationship between prenatal exposure to analgesics and the risk of schizophrenia. The effect of prenatal exposure was adjusted for parental history of schizophrenia, second-trimester viral infections, concomitant drug treatment during pregnancy, an index of pregnancy complications, parental social status and parental age. RESULTS: In a risk set of 7999 individuals, 116 cases of schizophrenia were found (1.5%). Prenatal exposure to analgesics in the second trimester was associated with an elevated risk (adjusted odds ratio 4.75, 95% CI1.9-12.0). Independent of the covariates, the effect remained statistically significant. CONCLUSIONS: Independent of a wide range of possible confounders, a significant association between second-trimester exposure to analgesics and increased risk of schizophrenia was observed.

U2 - http://dx.doi.org/10.1192/bjp.185.5.366

DO - http://dx.doi.org/10.1192/bjp.185.5.366

M3 - Journal article

VL - 185

SP - 366

EP - 371

JO - British Journal of Psychiatry

JF - British Journal of Psychiatry

SN - 0007-1250

IS - 185

ER -

ID: 107102