Association of GDF15 With Inflammation and Physical Function During Aging and Recovery After Acute Hospitalization: A Longitudinal Study of Older Patients and Age-Matched Controls
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Association of GDF15 With Inflammation and Physical Function During Aging and Recovery After Acute Hospitalization : A Longitudinal Study of Older Patients and Age-Matched Controls. / Tavenier, Juliette; Rasmussen, Line Jee Hartmann; Andersen, Aino Leegaard; Houlind, Morten Baltzer; Langkilde, Anne; Andersen, Ove; Petersen, Janne; Nehlin, Jan O.
In: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 76, No. 6, 2021, p. 964-974.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Association of GDF15 With Inflammation and Physical Function During Aging and Recovery After Acute Hospitalization
T2 - A Longitudinal Study of Older Patients and Age-Matched Controls
AU - Tavenier, Juliette
AU - Rasmussen, Line Jee Hartmann
AU - Andersen, Aino Leegaard
AU - Houlind, Morten Baltzer
AU - Langkilde, Anne
AU - Andersen, Ove
AU - Petersen, Janne
AU - Nehlin, Jan O.
N1 - Publisher Copyright: © The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
PY - 2021
Y1 - 2021
N2 - Growth differentiation factor 15 (GDF15) is a stress-induced cytokine. Its plasma levels increase during aging and acute illness. In older Patients and age-matched Controls, we evaluated whether GDF15 levels (i) were associated with recovery after acute illness, and (ii) reflected different trajectories of aging and longitudinal changes in health measures. Fifty-two older Patients (≥65 years) were included upon admission to the emergency department (ED). At 30 days after discharge (time of matching), Patients were matched 1:1 on age and sex with Controls who had not been hospitalized within 2 years of inclusion. Both groups were followed up after 1 year. We assessed plasma levels of GDF15 and inflammatory biomarkers, frailty, nutritional status (mini nutritional assessment short-form), physical and cognitive function, and metabolic biomarkers. In Patients, elevated GDF15 levels at ED admission were associated with poorer resolution of inflammation (soluble urokinase plasminogen activator receptor [suPAR]), slowing of gait speed, and declining nutritional status between admission and 30-day follow-up. At time of matching, Patients were frailer and overall less healthy than age-matched Controls. GDF15 levels were significantly associated with participant group, on average Patients had almost 60% higher GDF15 than age-matched Controls, and this difference was partly mediated by reduced physical function. Increases in GDF15 levels between time of matching and 1-year follow-up were associated with increases in levels of interleukin-6 in Patients, and tumor necrosis factor-α and suPAR in age-matched Controls. In older adults, elevated GDF15 levels were associated with signs of accelerated aging and with poorer recovery after acute illness.
AB - Growth differentiation factor 15 (GDF15) is a stress-induced cytokine. Its plasma levels increase during aging and acute illness. In older Patients and age-matched Controls, we evaluated whether GDF15 levels (i) were associated with recovery after acute illness, and (ii) reflected different trajectories of aging and longitudinal changes in health measures. Fifty-two older Patients (≥65 years) were included upon admission to the emergency department (ED). At 30 days after discharge (time of matching), Patients were matched 1:1 on age and sex with Controls who had not been hospitalized within 2 years of inclusion. Both groups were followed up after 1 year. We assessed plasma levels of GDF15 and inflammatory biomarkers, frailty, nutritional status (mini nutritional assessment short-form), physical and cognitive function, and metabolic biomarkers. In Patients, elevated GDF15 levels at ED admission were associated with poorer resolution of inflammation (soluble urokinase plasminogen activator receptor [suPAR]), slowing of gait speed, and declining nutritional status between admission and 30-day follow-up. At time of matching, Patients were frailer and overall less healthy than age-matched Controls. GDF15 levels were significantly associated with participant group, on average Patients had almost 60% higher GDF15 than age-matched Controls, and this difference was partly mediated by reduced physical function. Increases in GDF15 levels between time of matching and 1-year follow-up were associated with increases in levels of interleukin-6 in Patients, and tumor necrosis factor-α and suPAR in age-matched Controls. In older adults, elevated GDF15 levels were associated with signs of accelerated aging and with poorer recovery after acute illness.
KW - Chronic inflammation
KW - Emergency department
KW - Frailty
KW - Nutritional status
KW - Resilience
U2 - 10.1093/gerona/glab011
DO - 10.1093/gerona/glab011
M3 - Journal article
C2 - 33428715
AN - SCOPUS:85106146595
VL - 76
SP - 964
EP - 974
JO - Journals of Gerontology. Series A: Biological Sciences & Medical Sciences
JF - Journals of Gerontology. Series A: Biological Sciences & Medical Sciences
SN - 1079-5006
IS - 6
ER -
ID: 272234413