Associations between enteral nutrition and outcomes in the SUP-ICU trial: Protocol for exploratory post hoc analyses

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Associations between enteral nutrition and outcomes in the SUP-ICU trial : Protocol for exploratory post hoc analyses. / Borthwick, Mark; Granholm, Anders; Marker, Søren; Krag, Mette; Lange, Theis; Wise, Matt P.; Bendel, Stepani; Keus, Frederik; Guttormsen, Anne Berit; Schefold, Joerg C.; Wetterslev, Jørn; Perner, Anders; Moller, Morten Hylander; SUP-ICU investigators.

In: Acta Anaesthesiologica Scandinavica, Vol. 67, No. 4, 2023, p. 481-486.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Borthwick, M, Granholm, A, Marker, S, Krag, M, Lange, T, Wise, MP, Bendel, S, Keus, F, Guttormsen, AB, Schefold, JC, Wetterslev, J, Perner, A, Moller, MH & SUP-ICU investigators 2023, 'Associations between enteral nutrition and outcomes in the SUP-ICU trial: Protocol for exploratory post hoc analyses', Acta Anaesthesiologica Scandinavica, vol. 67, no. 4, pp. 481-486. https://doi.org/10.1111/aas.14194

APA

Borthwick, M., Granholm, A., Marker, S., Krag, M., Lange, T., Wise, M. P., Bendel, S., Keus, F., Guttormsen, A. B., Schefold, J. C., Wetterslev, J., Perner, A., Moller, M. H., & SUP-ICU investigators (2023). Associations between enteral nutrition and outcomes in the SUP-ICU trial: Protocol for exploratory post hoc analyses. Acta Anaesthesiologica Scandinavica, 67(4), 481-486. https://doi.org/10.1111/aas.14194

Vancouver

Borthwick M, Granholm A, Marker S, Krag M, Lange T, Wise MP et al. Associations between enteral nutrition and outcomes in the SUP-ICU trial: Protocol for exploratory post hoc analyses. Acta Anaesthesiologica Scandinavica. 2023;67(4):481-486. https://doi.org/10.1111/aas.14194

Author

Borthwick, Mark ; Granholm, Anders ; Marker, Søren ; Krag, Mette ; Lange, Theis ; Wise, Matt P. ; Bendel, Stepani ; Keus, Frederik ; Guttormsen, Anne Berit ; Schefold, Joerg C. ; Wetterslev, Jørn ; Perner, Anders ; Moller, Morten Hylander ; SUP-ICU investigators. / Associations between enteral nutrition and outcomes in the SUP-ICU trial : Protocol for exploratory post hoc analyses. In: Acta Anaesthesiologica Scandinavica. 2023 ; Vol. 67, No. 4. pp. 481-486.

Bibtex

@article{412047cef6544771936e6a3e7bec3554,
title = "Associations between enteral nutrition and outcomes in the SUP-ICU trial: Protocol for exploratory post hoc analyses",
abstract = "Critically ill patients are at risk of gastrointestinal (GI) bleeding. Counter measures to minimise this risk include the use of pharmacological stress ulcer prophylaxis (SUP). The effect of enteral nutrition as SUP on GI bleeding event rates is unknown. There are conflicting data describing the effect of co-administration of enteral nutrition with pharmacological SUP, and there is substantial variation in practice. We aim to conduct an exploratory post hoc analysis to evaluate the association of enteral nutrition with clinically important GI bleed rates in ICU patients included in the SUP-ICU trial, and to explore any interactions between enteral nutrition and pharmacologic SUP on patient outcomes. The SUP-ICU trial dataset will be used to assess if enteral nutrition is associated with the outcomes of interest. Extended Cox models will be used considering relevant competing events, including treatment allocation (SUP or placebo) and enteral nutrition as a daily time-varying covariate, with additional adjustment for severity of illness (SAPS II). Results will be presented as adjusted hazard ratios for treatment allocation and enteral nutrition, and for treatment allocation and enteral nutrition considering potential interactions with the other variable, all with 95% confidence intervals and p-values for the tests of interaction. All results will be considered as exploratory only. This post hoc analysis may yield important insights to guide practice and inform the design of future randomised clinical trial investigating the effect of enteral nutrition on GI bleeding.",
keywords = "enteral nutrition, pantoprazole, protocol, proton pump inhibitor, stress ulcer prophylaxis, STRESS-ULCER PROPHYLAXIS, CRITICALLY-ILL PATIENTS, INTENSIVE-CARE-UNIT, SURVIVAL ANALYSIS, IMPUTATION, SCORE",
author = "Mark Borthwick and Anders Granholm and S{\o}ren Marker and Mette Krag and Theis Lange and Wise, {Matt P.} and Stepani Bendel and Frederik Keus and Guttormsen, {Anne Berit} and Schefold, {Joerg C.} and J{\o}rn Wetterslev and Anders Perner and Moller, {Morten Hylander} and {SUP-ICU investigators}",
year = "2023",
doi = "10.1111/aas.14194",
language = "English",
volume = "67",
pages = "481--486",
journal = "Acta Anaesthesiologica Scandinavica",
issn = "0001-5172",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Associations between enteral nutrition and outcomes in the SUP-ICU trial

T2 - Protocol for exploratory post hoc analyses

AU - Borthwick, Mark

AU - Granholm, Anders

AU - Marker, Søren

AU - Krag, Mette

AU - Lange, Theis

AU - Wise, Matt P.

AU - Bendel, Stepani

AU - Keus, Frederik

AU - Guttormsen, Anne Berit

AU - Schefold, Joerg C.

AU - Wetterslev, Jørn

AU - Perner, Anders

AU - Moller, Morten Hylander

AU - SUP-ICU investigators

PY - 2023

Y1 - 2023

N2 - Critically ill patients are at risk of gastrointestinal (GI) bleeding. Counter measures to minimise this risk include the use of pharmacological stress ulcer prophylaxis (SUP). The effect of enteral nutrition as SUP on GI bleeding event rates is unknown. There are conflicting data describing the effect of co-administration of enteral nutrition with pharmacological SUP, and there is substantial variation in practice. We aim to conduct an exploratory post hoc analysis to evaluate the association of enteral nutrition with clinically important GI bleed rates in ICU patients included in the SUP-ICU trial, and to explore any interactions between enteral nutrition and pharmacologic SUP on patient outcomes. The SUP-ICU trial dataset will be used to assess if enteral nutrition is associated with the outcomes of interest. Extended Cox models will be used considering relevant competing events, including treatment allocation (SUP or placebo) and enteral nutrition as a daily time-varying covariate, with additional adjustment for severity of illness (SAPS II). Results will be presented as adjusted hazard ratios for treatment allocation and enteral nutrition, and for treatment allocation and enteral nutrition considering potential interactions with the other variable, all with 95% confidence intervals and p-values for the tests of interaction. All results will be considered as exploratory only. This post hoc analysis may yield important insights to guide practice and inform the design of future randomised clinical trial investigating the effect of enteral nutrition on GI bleeding.

AB - Critically ill patients are at risk of gastrointestinal (GI) bleeding. Counter measures to minimise this risk include the use of pharmacological stress ulcer prophylaxis (SUP). The effect of enteral nutrition as SUP on GI bleeding event rates is unknown. There are conflicting data describing the effect of co-administration of enteral nutrition with pharmacological SUP, and there is substantial variation in practice. We aim to conduct an exploratory post hoc analysis to evaluate the association of enteral nutrition with clinically important GI bleed rates in ICU patients included in the SUP-ICU trial, and to explore any interactions between enteral nutrition and pharmacologic SUP on patient outcomes. The SUP-ICU trial dataset will be used to assess if enteral nutrition is associated with the outcomes of interest. Extended Cox models will be used considering relevant competing events, including treatment allocation (SUP or placebo) and enteral nutrition as a daily time-varying covariate, with additional adjustment for severity of illness (SAPS II). Results will be presented as adjusted hazard ratios for treatment allocation and enteral nutrition, and for treatment allocation and enteral nutrition considering potential interactions with the other variable, all with 95% confidence intervals and p-values for the tests of interaction. All results will be considered as exploratory only. This post hoc analysis may yield important insights to guide practice and inform the design of future randomised clinical trial investigating the effect of enteral nutrition on GI bleeding.

KW - enteral nutrition

KW - pantoprazole

KW - protocol

KW - proton pump inhibitor

KW - stress ulcer prophylaxis

KW - STRESS-ULCER PROPHYLAXIS

KW - CRITICALLY-ILL PATIENTS

KW - INTENSIVE-CARE-UNIT

KW - SURVIVAL ANALYSIS

KW - IMPUTATION

KW - SCORE

U2 - 10.1111/aas.14194

DO - 10.1111/aas.14194

M3 - Journal article

C2 - 36636785

VL - 67

SP - 481

EP - 486

JO - Acta Anaesthesiologica Scandinavica

JF - Acta Anaesthesiologica Scandinavica

SN - 0001-5172

IS - 4

ER -

ID: 337782831