Bioassay-guided isolation of apigenin with GABA-benzodiazepine activity from Tanacetum parthenium

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Bioassay-guided isolation of apigenin with GABA-benzodiazepine activity from Tanacetum parthenium. / Jäger, Anna Katharina; Krydsfeldt, Katrine; Rasmussen, Hasse Bonde.

In: Phytotherapy Research, Vol. 23, No. 11, 2009, p. 1642-1644.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jäger, AK, Krydsfeldt, K & Rasmussen, HB 2009, 'Bioassay-guided isolation of apigenin with GABA-benzodiazepine activity from Tanacetum parthenium', Phytotherapy Research, vol. 23, no. 11, pp. 1642-1644. https://doi.org/10.1002/ptr.2816

APA

Jäger, A. K., Krydsfeldt, K., & Rasmussen, H. B. (2009). Bioassay-guided isolation of apigenin with GABA-benzodiazepine activity from Tanacetum parthenium. Phytotherapy Research, 23(11), 1642-1644. https://doi.org/10.1002/ptr.2816

Vancouver

Jäger AK, Krydsfeldt K, Rasmussen HB. Bioassay-guided isolation of apigenin with GABA-benzodiazepine activity from Tanacetum parthenium. Phytotherapy Research. 2009;23(11):1642-1644. https://doi.org/10.1002/ptr.2816

Author

Jäger, Anna Katharina ; Krydsfeldt, Katrine ; Rasmussen, Hasse Bonde. / Bioassay-guided isolation of apigenin with GABA-benzodiazepine activity from Tanacetum parthenium. In: Phytotherapy Research. 2009 ; Vol. 23, No. 11. pp. 1642-1644.

Bibtex

@article{a953baa0986111de8bc9000ea68e967b,
title = "Bioassay-guided isolation of apigenin with GABA-benzodiazepine activity from Tanacetum parthenium",
abstract = "Extracts of Tanacetum parthenium are used in the prophylactic treatment of migraine and have also been used in Danish folk medicine for the treatment of epilepsy. An ethanol extract of T. parthenium showed high affinity for the GABA(A)-benzodiazepine site. An ethanol extract of T. parthenium was fractionated by VLC on silica and preparative C18 HPLC. Each step was monitored with the GABA(A)-benzodiazepine bioassay. The fractionation led to the isolation of apigenin, which may be responsible for CNS-effects of T. parthenium extracts. Copyright (c) 2009 John Wiley & Sons, Ltd.",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "J{\"a}ger, {Anna Katharina} and Katrine Krydsfeldt and Rasmussen, {Hasse Bonde}",
note = "Keywords: apigenin; benzodiazepine site; GABA; Tanacetum parthenium",
year = "2009",
doi = "10.1002/ptr.2816",
language = "English",
volume = "23",
pages = "1642--1644",
journal = "Phytotherapy Research",
issn = "0951-418X",
publisher = "JohnWiley & Sons Ltd",
number = "11",

}

RIS

TY - JOUR

T1 - Bioassay-guided isolation of apigenin with GABA-benzodiazepine activity from Tanacetum parthenium

AU - Jäger, Anna Katharina

AU - Krydsfeldt, Katrine

AU - Rasmussen, Hasse Bonde

N1 - Keywords: apigenin; benzodiazepine site; GABA; Tanacetum parthenium

PY - 2009

Y1 - 2009

N2 - Extracts of Tanacetum parthenium are used in the prophylactic treatment of migraine and have also been used in Danish folk medicine for the treatment of epilepsy. An ethanol extract of T. parthenium showed high affinity for the GABA(A)-benzodiazepine site. An ethanol extract of T. parthenium was fractionated by VLC on silica and preparative C18 HPLC. Each step was monitored with the GABA(A)-benzodiazepine bioassay. The fractionation led to the isolation of apigenin, which may be responsible for CNS-effects of T. parthenium extracts. Copyright (c) 2009 John Wiley & Sons, Ltd.

AB - Extracts of Tanacetum parthenium are used in the prophylactic treatment of migraine and have also been used in Danish folk medicine for the treatment of epilepsy. An ethanol extract of T. parthenium showed high affinity for the GABA(A)-benzodiazepine site. An ethanol extract of T. parthenium was fractionated by VLC on silica and preparative C18 HPLC. Each step was monitored with the GABA(A)-benzodiazepine bioassay. The fractionation led to the isolation of apigenin, which may be responsible for CNS-effects of T. parthenium extracts. Copyright (c) 2009 John Wiley & Sons, Ltd.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1002/ptr.2816

DO - 10.1002/ptr.2816

M3 - Journal article

C2 - 19441011

VL - 23

SP - 1642

EP - 1644

JO - Phytotherapy Research

JF - Phytotherapy Research

SN - 0951-418X

IS - 11

ER -

ID: 14148302