Body Characteristics, Dietary Protein and Body Weight Regulation: Reconciling Conflicting Results from Intervention and Observational Studies?

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Standard

Body Characteristics, Dietary Protein and Body Weight Regulation : Reconciling Conflicting Results from Intervention and Observational Studies? / Ankarfeldt, Mikkel Zøllner; Ängquist, Lars; Stocks, Tanja; Jakobsen, Marianne Uhre; Overvad, Kim; Halkjær, Jytte; Saris, Wim H M; Astrup, Arne; Sørensen, Thorkild I.A.

In: P L o S One, Vol. 9, No. 7, e101134, 2014, p. 1-8.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Ankarfeldt, MZ, Ängquist, L, Stocks, T, Jakobsen, MU, Overvad, K, Halkjær, J, Saris, WHM, Astrup, A & Sørensen, TIA 2014, 'Body Characteristics, Dietary Protein and Body Weight Regulation: Reconciling Conflicting Results from Intervention and Observational Studies?' P L o S One, vol. 9, no. 7, e101134, pp. 1-8. https://doi.org/10.1371/journal.pone.0101134

APA

Ankarfeldt, M. Z., Ängquist, L., Stocks, T., Jakobsen, M. U., Overvad, K., Halkjær, J., ... Sørensen, T. I. A. (2014). Body Characteristics, Dietary Protein and Body Weight Regulation: Reconciling Conflicting Results from Intervention and Observational Studies? P L o S One, 9(7), 1-8. [e101134]. https://doi.org/10.1371/journal.pone.0101134

Vancouver

Ankarfeldt MZ, Ängquist L, Stocks T, Jakobsen MU, Overvad K, Halkjær J et al. Body Characteristics, Dietary Protein and Body Weight Regulation: Reconciling Conflicting Results from Intervention and Observational Studies? P L o S One. 2014;9(7):1-8. e101134. https://doi.org/10.1371/journal.pone.0101134

Author

Ankarfeldt, Mikkel Zøllner ; Ängquist, Lars ; Stocks, Tanja ; Jakobsen, Marianne Uhre ; Overvad, Kim ; Halkjær, Jytte ; Saris, Wim H M ; Astrup, Arne ; Sørensen, Thorkild I.A. / Body Characteristics, Dietary Protein and Body Weight Regulation : Reconciling Conflicting Results from Intervention and Observational Studies?. In: P L o S One. 2014 ; Vol. 9, No. 7. pp. 1-8.

Bibtex

@article{28644b023e854c4f91b1a3c59d2e84a3,
title = "Body Characteristics, Dietary Protein and Body Weight Regulation: Reconciling Conflicting Results from Intervention and Observational Studies?",
abstract = "BACKGROUND/OBJECTIVES: Physiological evidence indicates that high-protein diets reduce caloric intake and increase thermogenic response, which may prevent weight gain and regain after weight loss. Clinical trials have shown such effects, whereas observational cohort studies suggest an association between greater protein intake and weight gain. In both types of studies the results are based on average weight changes, and show considerable diversity in both directions. This study investigates whether the discrepancy in the evidence could be due to recruitment of overweight and obese individuals into clinical trials.SUBJECTS/METHODS: Data were available from the European Diet, Obesity and Genes (DiOGenes) post-weight-loss weight-maintenance trial and the Danish Diet, Cancer and Health (DCH) cohort. Participants of the DCH cohort were matched with participants from the DiOGenes trial on gender, diet, and body characteristics. Different subsets of the DCH-participants, comparable with the trial participants, were analyzed for weight maintenance according to the randomization status (high or low protein) of the matched trial participants.RESULTS: Trial participants were generally heavier, had larger waist circumference and larger fat mass than the participants in the entire DCH cohort. A better weight maintenance in the high-protein group compared to the low protein group was observed in the subgroups of the DCH cohort matching body characteristics of the trial participants.CONCLUSION: This modified observational study, minimized the differences between the RCT and observational data with regard to dietary intake, participant characteristics and statistical analysis. Compared with low protein diet the high protein diet was associated with better weight maintenance when individuals with greater body mass index and waist circumference were analyzed. Selecting subsets of large-scale observational cohort studies with similar characteristics as participants in clinical trials may reconcile the otherwise conflicting results.",
author = "Ankarfeldt, {Mikkel Z{\o}llner} and Lars {\"A}ngquist and Tanja Stocks and Jakobsen, {Marianne Uhre} and Kim Overvad and Jytte Halkj{\ae}r and Saris, {Wim H M} and Arne Astrup and S{\o}rensen, {Thorkild I.A.}",
note = "OA",
year = "2014",
doi = "10.1371/journal.pone.0101134",
language = "English",
volume = "9",
pages = "1--8",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "7",

}

RIS

TY - JOUR

T1 - Body Characteristics, Dietary Protein and Body Weight Regulation

T2 - Reconciling Conflicting Results from Intervention and Observational Studies?

AU - Ankarfeldt, Mikkel Zøllner

AU - Ängquist, Lars

AU - Stocks, Tanja

AU - Jakobsen, Marianne Uhre

AU - Overvad, Kim

AU - Halkjær, Jytte

AU - Saris, Wim H M

AU - Astrup, Arne

AU - Sørensen, Thorkild I.A.

N1 - OA

PY - 2014

Y1 - 2014

N2 - BACKGROUND/OBJECTIVES: Physiological evidence indicates that high-protein diets reduce caloric intake and increase thermogenic response, which may prevent weight gain and regain after weight loss. Clinical trials have shown such effects, whereas observational cohort studies suggest an association between greater protein intake and weight gain. In both types of studies the results are based on average weight changes, and show considerable diversity in both directions. This study investigates whether the discrepancy in the evidence could be due to recruitment of overweight and obese individuals into clinical trials.SUBJECTS/METHODS: Data were available from the European Diet, Obesity and Genes (DiOGenes) post-weight-loss weight-maintenance trial and the Danish Diet, Cancer and Health (DCH) cohort. Participants of the DCH cohort were matched with participants from the DiOGenes trial on gender, diet, and body characteristics. Different subsets of the DCH-participants, comparable with the trial participants, were analyzed for weight maintenance according to the randomization status (high or low protein) of the matched trial participants.RESULTS: Trial participants were generally heavier, had larger waist circumference and larger fat mass than the participants in the entire DCH cohort. A better weight maintenance in the high-protein group compared to the low protein group was observed in the subgroups of the DCH cohort matching body characteristics of the trial participants.CONCLUSION: This modified observational study, minimized the differences between the RCT and observational data with regard to dietary intake, participant characteristics and statistical analysis. Compared with low protein diet the high protein diet was associated with better weight maintenance when individuals with greater body mass index and waist circumference were analyzed. Selecting subsets of large-scale observational cohort studies with similar characteristics as participants in clinical trials may reconcile the otherwise conflicting results.

AB - BACKGROUND/OBJECTIVES: Physiological evidence indicates that high-protein diets reduce caloric intake and increase thermogenic response, which may prevent weight gain and regain after weight loss. Clinical trials have shown such effects, whereas observational cohort studies suggest an association between greater protein intake and weight gain. In both types of studies the results are based on average weight changes, and show considerable diversity in both directions. This study investigates whether the discrepancy in the evidence could be due to recruitment of overweight and obese individuals into clinical trials.SUBJECTS/METHODS: Data were available from the European Diet, Obesity and Genes (DiOGenes) post-weight-loss weight-maintenance trial and the Danish Diet, Cancer and Health (DCH) cohort. Participants of the DCH cohort were matched with participants from the DiOGenes trial on gender, diet, and body characteristics. Different subsets of the DCH-participants, comparable with the trial participants, were analyzed for weight maintenance according to the randomization status (high or low protein) of the matched trial participants.RESULTS: Trial participants were generally heavier, had larger waist circumference and larger fat mass than the participants in the entire DCH cohort. A better weight maintenance in the high-protein group compared to the low protein group was observed in the subgroups of the DCH cohort matching body characteristics of the trial participants.CONCLUSION: This modified observational study, minimized the differences between the RCT and observational data with regard to dietary intake, participant characteristics and statistical analysis. Compared with low protein diet the high protein diet was associated with better weight maintenance when individuals with greater body mass index and waist circumference were analyzed. Selecting subsets of large-scale observational cohort studies with similar characteristics as participants in clinical trials may reconcile the otherwise conflicting results.

U2 - 10.1371/journal.pone.0101134

DO - 10.1371/journal.pone.0101134

M3 - Journal article

VL - 9

SP - 1

EP - 8

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 7

M1 - e101134

ER -

ID: 120070789