Body mass index in young school-age children in relation to organochlorine compounds in early life: a prospective study

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Standard

Body mass index in young school-age children in relation to organochlorine compounds in early life : a prospective study. / Høyer, B B; Ramlau-Hansen, C H; Henriksen, T B; Pedersen, H S; Góralczyk, K; Zviezdai, V; Jönsson, B A G; Heederik, D; Lenters, V; Vermeulen, R; Bonde, J P; Toft, G.

In: International journal of obesity (2005), Vol. 38, No. 7, 07.2014, p. 919-925.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Høyer, BB, Ramlau-Hansen, CH, Henriksen, TB, Pedersen, HS, Góralczyk, K, Zviezdai, V, Jönsson, BAG, Heederik, D, Lenters, V, Vermeulen, R, Bonde, JP & Toft, G 2014, 'Body mass index in young school-age children in relation to organochlorine compounds in early life: a prospective study', International journal of obesity (2005), vol. 38, no. 7, pp. 919-925. https://doi.org/10.1038/ijo.2014.58

APA

Høyer, B. B., Ramlau-Hansen, C. H., Henriksen, T. B., Pedersen, H. S., Góralczyk, K., Zviezdai, V., Jönsson, B. A. G., Heederik, D., Lenters, V., Vermeulen, R., Bonde, J. P., & Toft, G. (2014). Body mass index in young school-age children in relation to organochlorine compounds in early life: a prospective study. International journal of obesity (2005), 38(7), 919-925. https://doi.org/10.1038/ijo.2014.58

Vancouver

Høyer BB, Ramlau-Hansen CH, Henriksen TB, Pedersen HS, Góralczyk K, Zviezdai V et al. Body mass index in young school-age children in relation to organochlorine compounds in early life: a prospective study. International journal of obesity (2005). 2014 Jul;38(7):919-925. https://doi.org/10.1038/ijo.2014.58

Author

Høyer, B B ; Ramlau-Hansen, C H ; Henriksen, T B ; Pedersen, H S ; Góralczyk, K ; Zviezdai, V ; Jönsson, B A G ; Heederik, D ; Lenters, V ; Vermeulen, R ; Bonde, J P ; Toft, G. / Body mass index in young school-age children in relation to organochlorine compounds in early life : a prospective study. In: International journal of obesity (2005). 2014 ; Vol. 38, No. 7. pp. 919-925.

Bibtex

@article{9eb376f78a204068a6b7fbaf6a2999d2,
title = "Body mass index in young school-age children in relation to organochlorine compounds in early life: a prospective study",
abstract = "OBJECTIVE: To investigate the association between maternal pregnancy and estimated postnatal serum concentrations of the organochlorines 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) and body mass index (BMI) z-scores in 5- to 9-year-old children.METHODS: Maternal sera from the INUENDO birth cohort (2002-2004) comprising mother-child pairs (N=1109) from Greenland, Warsaw (Poland), and Kharkiv (Ukraine) were analysed for CB-153 and p,p'-DDE, using gas chromatography-mass-spectrometry, and were grouped into tertiles for statistical analyses. A toxicokinetic model was used to estimate the first 12 months cumulative exposure to the compounds. Associations between these compounds and child age- and sex-specific BMI z-scores were calculated at follow-up (2010-2012), using multiple linear regression analysis.RESULTS: No clear associations between pregnancy CB-153 and p,p'-DDE and child BMI were observed (the pooled differences in BMI z-score (95% confidence interval) comparing 3rd tertile to 1st tertile were -0.07 (-0.32 to 0.18) and -0.10 (-0.30 to 0.10)  kg m(-2), respectively). For postnatal CB-153 and p,p'-DDE and BMI, the overall differences in BMI z-score comparing 3rd tertile to 1st tertile were 0.12 (-0.15 to 0.39) and -0.03 (-0.20 to 0.27) kg m(-2), respectively.CONCLUSIONS: This follow-up study of Greenlandic, Polish and Ukrainian populations showed no clear association between pregnancy and postnatal exposure to p,p'-DDE and CB-153 and BMI at the age of 5-9 years.",
keywords = "Adult, Body Mass Index, Child, Child, Preschool, DDT, Environmental Exposure, Environmental Pollutants, European Continental Ancestry Group, Female, Follow-Up Studies, Greenland, Humans, Hydrocarbons, Chlorinated, Male, Mothers, Poland, Polychlorinated Biphenyls, Pregnancy, Prenatal Exposure Delayed Effects, Prospective Studies, Ukraine",
author = "H{\o}yer, {B B} and Ramlau-Hansen, {C H} and Henriksen, {T B} and Pedersen, {H S} and K G{\'o}ralczyk and V Zviezdai and J{\"o}nsson, {B A G} and D Heederik and V Lenters and R Vermeulen and Bonde, {J P} and G Toft",
year = "2014",
month = jul,
doi = "10.1038/ijo.2014.58",
language = "English",
volume = "38",
pages = "919--925",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "nature publishing group",
number = "7",

}

RIS

TY - JOUR

T1 - Body mass index in young school-age children in relation to organochlorine compounds in early life

T2 - a prospective study

AU - Høyer, B B

AU - Ramlau-Hansen, C H

AU - Henriksen, T B

AU - Pedersen, H S

AU - Góralczyk, K

AU - Zviezdai, V

AU - Jönsson, B A G

AU - Heederik, D

AU - Lenters, V

AU - Vermeulen, R

AU - Bonde, J P

AU - Toft, G

PY - 2014/7

Y1 - 2014/7

N2 - OBJECTIVE: To investigate the association between maternal pregnancy and estimated postnatal serum concentrations of the organochlorines 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) and body mass index (BMI) z-scores in 5- to 9-year-old children.METHODS: Maternal sera from the INUENDO birth cohort (2002-2004) comprising mother-child pairs (N=1109) from Greenland, Warsaw (Poland), and Kharkiv (Ukraine) were analysed for CB-153 and p,p'-DDE, using gas chromatography-mass-spectrometry, and were grouped into tertiles for statistical analyses. A toxicokinetic model was used to estimate the first 12 months cumulative exposure to the compounds. Associations between these compounds and child age- and sex-specific BMI z-scores were calculated at follow-up (2010-2012), using multiple linear regression analysis.RESULTS: No clear associations between pregnancy CB-153 and p,p'-DDE and child BMI were observed (the pooled differences in BMI z-score (95% confidence interval) comparing 3rd tertile to 1st tertile were -0.07 (-0.32 to 0.18) and -0.10 (-0.30 to 0.10)  kg m(-2), respectively). For postnatal CB-153 and p,p'-DDE and BMI, the overall differences in BMI z-score comparing 3rd tertile to 1st tertile were 0.12 (-0.15 to 0.39) and -0.03 (-0.20 to 0.27) kg m(-2), respectively.CONCLUSIONS: This follow-up study of Greenlandic, Polish and Ukrainian populations showed no clear association between pregnancy and postnatal exposure to p,p'-DDE and CB-153 and BMI at the age of 5-9 years.

AB - OBJECTIVE: To investigate the association between maternal pregnancy and estimated postnatal serum concentrations of the organochlorines 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) and body mass index (BMI) z-scores in 5- to 9-year-old children.METHODS: Maternal sera from the INUENDO birth cohort (2002-2004) comprising mother-child pairs (N=1109) from Greenland, Warsaw (Poland), and Kharkiv (Ukraine) were analysed for CB-153 and p,p'-DDE, using gas chromatography-mass-spectrometry, and were grouped into tertiles for statistical analyses. A toxicokinetic model was used to estimate the first 12 months cumulative exposure to the compounds. Associations between these compounds and child age- and sex-specific BMI z-scores were calculated at follow-up (2010-2012), using multiple linear regression analysis.RESULTS: No clear associations between pregnancy CB-153 and p,p'-DDE and child BMI were observed (the pooled differences in BMI z-score (95% confidence interval) comparing 3rd tertile to 1st tertile were -0.07 (-0.32 to 0.18) and -0.10 (-0.30 to 0.10)  kg m(-2), respectively). For postnatal CB-153 and p,p'-DDE and BMI, the overall differences in BMI z-score comparing 3rd tertile to 1st tertile were 0.12 (-0.15 to 0.39) and -0.03 (-0.20 to 0.27) kg m(-2), respectively.CONCLUSIONS: This follow-up study of Greenlandic, Polish and Ukrainian populations showed no clear association between pregnancy and postnatal exposure to p,p'-DDE and CB-153 and BMI at the age of 5-9 years.

KW - Adult

KW - Body Mass Index

KW - Child

KW - Child, Preschool

KW - DDT

KW - Environmental Exposure

KW - Environmental Pollutants

KW - European Continental Ancestry Group

KW - Female

KW - Follow-Up Studies

KW - Greenland

KW - Humans

KW - Hydrocarbons, Chlorinated

KW - Male

KW - Mothers

KW - Poland

KW - Polychlorinated Biphenyls

KW - Pregnancy

KW - Prenatal Exposure Delayed Effects

KW - Prospective Studies

KW - Ukraine

U2 - 10.1038/ijo.2014.58

DO - 10.1038/ijo.2014.58

M3 - Journal article

C2 - 24718355

VL - 38

SP - 919

EP - 925

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

IS - 7

ER -

ID: 138553676