Breast density and outcome of mammography screening: a cohort study
Research output: Contribution to journal › Journal article › peer-review
The purpose of this study was to investigate the effect of breast density on breast cancer (BC) mortality in a mammography screening programme. The cohort included 48 052 women participating in mammography screening in Copenhagen, Denmark, where biennial screening is offered to women aged 50-69 years. We collected information for the years 1991-2001 on screening outcome, incident BCs (screen-, interval-, and later detected), and BC deaths. Breast density was dichotomised into fatty (F) and mixed/dense (M/D) breasts. Screening sensitivity was measured as the odds ratio of interval versus screen-detected cancer for dense versus F breasts. Poisson regression was used to estimate the ratios for BC incidence, case fatality, and mortality between women with M/D and F breasts. For women with M/D breasts, the odds ratio of an interval cancer was 1.62 (95% confidence interval, CI, 1.14-2.30), and the age-adjusted rate ratios were 2.45 (95% CI 2.14-2.81) for BC incidence, 0.60 (95% CI 0.43-0.84) for case fatality, and 1.78 (95% CI 1.17-2.72) for BC mortality. The study shows that BC in women with M/D breasts is more frequent, but on average less severe, than in women with F breasts.
Original language | English |
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Journal | British Journal of Cancer |
Volume | 100 |
Issue number | 7 |
Pages (from-to) | 1205-8 |
Number of pages | 3 |
ISSN | 0007-0920 |
DOIs | |
Publication status | Published - 2009 |
Bibliographical note
Keywords: Aged; Breast; Breast Neoplasms; Cohort Studies; Female; Humans; Incidence; Mammography; Mass Screening; Middle Aged; Poisson Distribution; Receptors, Estrogen
ID: 14277943