Cancer Risk following Residential Exposure to Airborne Polychlorinated Biphenyls: A Danish Register-Based Cohort Study
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Cancer Risk following Residential Exposure to Airborne Polychlorinated Biphenyls : A Danish Register-Based Cohort Study. / Deen, Laura; Hougaard, Karin Sørig; Clark, Alice; Meyer, Harald William; Frederiksen, Marie; Gunnarsen, Lars; Andersen, Helle Vibeke; Hougaard, Thomas; Petersen, Kajsa Kirstine Ugelvig; Ebbehøj, Niels Erik; Bonde, Jens Peter; Tøttenborg, Sandra Søgaard.
In: Environmental Health Perspectives, Vol. 130, No. 10, 107003, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Cancer Risk following Residential Exposure to Airborne Polychlorinated Biphenyls
T2 - A Danish Register-Based Cohort Study
AU - Deen, Laura
AU - Hougaard, Karin Sørig
AU - Clark, Alice
AU - Meyer, Harald William
AU - Frederiksen, Marie
AU - Gunnarsen, Lars
AU - Andersen, Helle Vibeke
AU - Hougaard, Thomas
AU - Petersen, Kajsa Kirstine Ugelvig
AU - Ebbehøj, Niels Erik
AU - Bonde, Jens Peter
AU - Tøttenborg, Sandra Søgaard
N1 - Publisher Copyright: © 2022, Public Health Services, US Dept of Health and Human Services. All rights reserved.
PY - 2022
Y1 - 2022
N2 - BACKGROUND: Polychlorinated biphenyls (PCBs) are biopersistent chemicals classified as human carcinogens. This classification is primarily based on evidence on higher-chlorinated PCBs found in food. The carcinogenic potential of airborne lower-chlorinated PCBs remains largely unexplored. OBJECTIVES: We aimed to investigate cancer risk following residential exposure to airborne PCBs. METHODS: Cancer risk was examined in the Health Effects of PCBs in Indoor Air (HESPAIR) cohort of 38,613 residents of two partly PCB-contaminated residential areas in Greater Copenhagen, identified by nationwide registries. PCB exposure was based on relocation dates and indoor air PCB measurements in subsets of apartments. Cancer diagnoses were extracted from the Danish Cancer Registry for the follow-up period of 1970– 2018. We estimated adjusted hazard ratios with time-varying cumulative exposure and a 10-y lag using Cox regression. RESULTS: Overall risk of cancer was not associated with PCByear, [hazard ratio (HR) for high-exposed vs. low-exposed = 0:98; 95% confidence inter-val (CI): 0.88, 1.09], but residents exposed to ≥3,000 ng/m3 PCB × year had higher risk of liver cancer (HR = 2:81; 95% CI: 1.28, 6.15) and menin-giomas (HR = 3:49; 95% CI: 1.84, 6.64), with indications of exposure–response relationships. Results were suggestive of a higher risk of pancreatic cancer (HR = 1:59; 95% CI: 0.95, 2.64) at the highest aggregated PCB level. For testis cancer, a higher risk was observed among residents exposed to 300–949 ng/m3 PCB × year relative to residents exposed to <300 ng/m3 PCB × year (HR = 2:97; 95% CI: 1.41, 6.28), but the risk was not higher for residents exposed to ≥950 ng/m3 PCB × year. Apart from this, the risk of specific cancers was similar across exposure groups. DISCUSSION: In this, to our knowledge, first population-based cohort study of residential exposure to airborne PCBs, we found no association between exposure to PCBs in indoor air in private homes and the risk for most of the specific cancers. Higher risk of liver cancer and meningiomas were observed. https://doi.org/10.1289/EHP10605.
AB - BACKGROUND: Polychlorinated biphenyls (PCBs) are biopersistent chemicals classified as human carcinogens. This classification is primarily based on evidence on higher-chlorinated PCBs found in food. The carcinogenic potential of airborne lower-chlorinated PCBs remains largely unexplored. OBJECTIVES: We aimed to investigate cancer risk following residential exposure to airborne PCBs. METHODS: Cancer risk was examined in the Health Effects of PCBs in Indoor Air (HESPAIR) cohort of 38,613 residents of two partly PCB-contaminated residential areas in Greater Copenhagen, identified by nationwide registries. PCB exposure was based on relocation dates and indoor air PCB measurements in subsets of apartments. Cancer diagnoses were extracted from the Danish Cancer Registry for the follow-up period of 1970– 2018. We estimated adjusted hazard ratios with time-varying cumulative exposure and a 10-y lag using Cox regression. RESULTS: Overall risk of cancer was not associated with PCByear, [hazard ratio (HR) for high-exposed vs. low-exposed = 0:98; 95% confidence inter-val (CI): 0.88, 1.09], but residents exposed to ≥3,000 ng/m3 PCB × year had higher risk of liver cancer (HR = 2:81; 95% CI: 1.28, 6.15) and menin-giomas (HR = 3:49; 95% CI: 1.84, 6.64), with indications of exposure–response relationships. Results were suggestive of a higher risk of pancreatic cancer (HR = 1:59; 95% CI: 0.95, 2.64) at the highest aggregated PCB level. For testis cancer, a higher risk was observed among residents exposed to 300–949 ng/m3 PCB × year relative to residents exposed to <300 ng/m3 PCB × year (HR = 2:97; 95% CI: 1.41, 6.28), but the risk was not higher for residents exposed to ≥950 ng/m3 PCB × year. Apart from this, the risk of specific cancers was similar across exposure groups. DISCUSSION: In this, to our knowledge, first population-based cohort study of residential exposure to airborne PCBs, we found no association between exposure to PCBs in indoor air in private homes and the risk for most of the specific cancers. Higher risk of liver cancer and meningiomas were observed. https://doi.org/10.1289/EHP10605.
U2 - 10.1289/EHP10605
DO - 10.1289/EHP10605
M3 - Journal article
C2 - 36306207
AN - SCOPUS:85141004794
VL - 130
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
SN - 0091-6765
IS - 10
M1 - 107003
ER -
ID: 344324596