Cardiorespiratory fitness and the metabolic syndrome: Roles of inflammation and abdominal obesity

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Cardiorespiratory fitness and the metabolic syndrome : Roles of inflammation and abdominal obesity. / Wedell-Neergaard, Anne-Sophie; Krogh-Madsen, Rikke; Petersen, Gitte Lindved; Hansen, Åse Marie; Pedersen, Bente Klarlund; Lund, Rikke; Bruunsgaard, Helle.

In: PLOS ONE, Vol. 13, No. 3, e0194991, 2018.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Wedell-Neergaard, A-S, Krogh-Madsen, R, Petersen, GL, Hansen, ÅM, Pedersen, BK, Lund, R & Bruunsgaard, H 2018, 'Cardiorespiratory fitness and the metabolic syndrome: Roles of inflammation and abdominal obesity' PLOS ONE, vol. 13, no. 3, e0194991. https://doi.org/10.1371/journal.pone.0194991

APA

Wedell-Neergaard, A-S., Krogh-Madsen, R., Petersen, G. L., Hansen, Å. M., Pedersen, B. K., Lund, R., & Bruunsgaard, H. (2018). Cardiorespiratory fitness and the metabolic syndrome: Roles of inflammation and abdominal obesity. PLOS ONE, 13(3), [e0194991]. https://doi.org/10.1371/journal.pone.0194991

Vancouver

Wedell-Neergaard A-S, Krogh-Madsen R, Petersen GL, Hansen ÅM, Pedersen BK, Lund R et al. Cardiorespiratory fitness and the metabolic syndrome: Roles of inflammation and abdominal obesity. PLOS ONE. 2018;13(3). e0194991. https://doi.org/10.1371/journal.pone.0194991

Author

Wedell-Neergaard, Anne-Sophie ; Krogh-Madsen, Rikke ; Petersen, Gitte Lindved ; Hansen, Åse Marie ; Pedersen, Bente Klarlund ; Lund, Rikke ; Bruunsgaard, Helle. / Cardiorespiratory fitness and the metabolic syndrome : Roles of inflammation and abdominal obesity. In: PLOS ONE. 2018 ; Vol. 13, No. 3.

Bibtex

@article{c320050053cb4772803cb2b5f2ea8c86,
title = "Cardiorespiratory fitness and the metabolic syndrome: Roles of inflammation and abdominal obesity",
abstract = "OBJECTIVE: Individuals with metabolic syndrome have increased risk of type 2 diabetes and cardiovascular disease. We aimed to test the hypothesis that a high level of cardiorespiratory fitness (CR-fitness), counteracts accumulation of visceral fat, decreases inflammation and lowers risk factors of the metabolic syndrome.METHOD: The study sample included 1,293 Danes (age 49-52 years) who from 2009 to 2011 participated in the Copenhagen Aging and Midlife Biobank, including a questionnaire, physical tests, and blood samples. Multiple linear regression models were performed with CR-fitness as exposure and plasma levels of cytokines and high sensitive C-reactive protein as outcomes and measures of abdominal obesity were added to test if they explained the potential association. Similarly, multiple linear regression models were performed with CR-fitness as exposure and factors of the metabolic syndrome as outcomes and the potential explanation by inflammatory biomarkers were tested. All models were adjusted for the effect of age, sex, smoking, alcohol consumption, socio-economic status, and acute inflammatory events within the preceding two weeks.RESULTS: CR-fitness was inversely associated with high sensitive C-reactive protein, Interleukin (IL)-6, and IL-18, and directly associated with the anti-inflammatory cytokine IL-10, but not associated with tumor necrosis factor alpha, interferon gamma or IL-1β. Abdominal obesity could partly explain the significant associations. Moreover, CR-fitness was inversely associated with an overall metabolic syndrome score, as well as triglycerides, glycated haemoglobin A1c, systolic blood pressure, diastolic blood pressure and directly associated with high-density lipoprotein. Single inflammatory biomarkers and a combined inflammatory score partly explained these associations.CONCLUSION: Data suggest that CR-fitness has anti-inflammatory effects that are partly explained by a reduction in abdominal obesity and a decrease in the metabolic syndrome risk profile. The overall inflammatory load was mainly driven by high sensitive C-reactive protein and IL-6.",
author = "Anne-Sophie Wedell-Neergaard and Rikke Krogh-Madsen and Petersen, {Gitte Lindved} and Hansen, {{\AA}se Marie} and Pedersen, {Bente Klarlund} and Rikke Lund and Helle Bruunsgaard",
year = "2018",
doi = "10.1371/journal.pone.0194991",
language = "English",
volume = "13",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "3",

}

RIS

TY - JOUR

T1 - Cardiorespiratory fitness and the metabolic syndrome

T2 - Roles of inflammation and abdominal obesity

AU - Wedell-Neergaard, Anne-Sophie

AU - Krogh-Madsen, Rikke

AU - Petersen, Gitte Lindved

AU - Hansen, Åse Marie

AU - Pedersen, Bente Klarlund

AU - Lund, Rikke

AU - Bruunsgaard, Helle

PY - 2018

Y1 - 2018

N2 - OBJECTIVE: Individuals with metabolic syndrome have increased risk of type 2 diabetes and cardiovascular disease. We aimed to test the hypothesis that a high level of cardiorespiratory fitness (CR-fitness), counteracts accumulation of visceral fat, decreases inflammation and lowers risk factors of the metabolic syndrome.METHOD: The study sample included 1,293 Danes (age 49-52 years) who from 2009 to 2011 participated in the Copenhagen Aging and Midlife Biobank, including a questionnaire, physical tests, and blood samples. Multiple linear regression models were performed with CR-fitness as exposure and plasma levels of cytokines and high sensitive C-reactive protein as outcomes and measures of abdominal obesity were added to test if they explained the potential association. Similarly, multiple linear regression models were performed with CR-fitness as exposure and factors of the metabolic syndrome as outcomes and the potential explanation by inflammatory biomarkers were tested. All models were adjusted for the effect of age, sex, smoking, alcohol consumption, socio-economic status, and acute inflammatory events within the preceding two weeks.RESULTS: CR-fitness was inversely associated with high sensitive C-reactive protein, Interleukin (IL)-6, and IL-18, and directly associated with the anti-inflammatory cytokine IL-10, but not associated with tumor necrosis factor alpha, interferon gamma or IL-1β. Abdominal obesity could partly explain the significant associations. Moreover, CR-fitness was inversely associated with an overall metabolic syndrome score, as well as triglycerides, glycated haemoglobin A1c, systolic blood pressure, diastolic blood pressure and directly associated with high-density lipoprotein. Single inflammatory biomarkers and a combined inflammatory score partly explained these associations.CONCLUSION: Data suggest that CR-fitness has anti-inflammatory effects that are partly explained by a reduction in abdominal obesity and a decrease in the metabolic syndrome risk profile. The overall inflammatory load was mainly driven by high sensitive C-reactive protein and IL-6.

AB - OBJECTIVE: Individuals with metabolic syndrome have increased risk of type 2 diabetes and cardiovascular disease. We aimed to test the hypothesis that a high level of cardiorespiratory fitness (CR-fitness), counteracts accumulation of visceral fat, decreases inflammation and lowers risk factors of the metabolic syndrome.METHOD: The study sample included 1,293 Danes (age 49-52 years) who from 2009 to 2011 participated in the Copenhagen Aging and Midlife Biobank, including a questionnaire, physical tests, and blood samples. Multiple linear regression models were performed with CR-fitness as exposure and plasma levels of cytokines and high sensitive C-reactive protein as outcomes and measures of abdominal obesity were added to test if they explained the potential association. Similarly, multiple linear regression models were performed with CR-fitness as exposure and factors of the metabolic syndrome as outcomes and the potential explanation by inflammatory biomarkers were tested. All models were adjusted for the effect of age, sex, smoking, alcohol consumption, socio-economic status, and acute inflammatory events within the preceding two weeks.RESULTS: CR-fitness was inversely associated with high sensitive C-reactive protein, Interleukin (IL)-6, and IL-18, and directly associated with the anti-inflammatory cytokine IL-10, but not associated with tumor necrosis factor alpha, interferon gamma or IL-1β. Abdominal obesity could partly explain the significant associations. Moreover, CR-fitness was inversely associated with an overall metabolic syndrome score, as well as triglycerides, glycated haemoglobin A1c, systolic blood pressure, diastolic blood pressure and directly associated with high-density lipoprotein. Single inflammatory biomarkers and a combined inflammatory score partly explained these associations.CONCLUSION: Data suggest that CR-fitness has anti-inflammatory effects that are partly explained by a reduction in abdominal obesity and a decrease in the metabolic syndrome risk profile. The overall inflammatory load was mainly driven by high sensitive C-reactive protein and IL-6.

U2 - 10.1371/journal.pone.0194991

DO - 10.1371/journal.pone.0194991

M3 - Journal article

VL - 13

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 3

M1 - e0194991

ER -

ID: 194525683