Cervical histology after routine ThinPrep or SurePath liquid-based cytology and computer-assisted reading in Denmark

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Cervical histology after routine ThinPrep or SurePath liquid-based cytology and computer-assisted reading in Denmark. / Rebolj, Matejka; Rask, Johanne; van Ballegooijen, Marjolein; Kirschner, Benny; Rozemeijer, Kirsten; Bonde, Jesper; Rygaard, Carsten; Lynge, Elsebeth.

In: B J C, Vol. 113, No. 9, 2015, p. 1259-74.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Rebolj, M, Rask, J, van Ballegooijen, M, Kirschner, B, Rozemeijer, K, Bonde, J, Rygaard, C & Lynge, E 2015, 'Cervical histology after routine ThinPrep or SurePath liquid-based cytology and computer-assisted reading in Denmark', B J C, vol. 113, no. 9, pp. 1259-74. https://doi.org/10.1038/bjc.2015.339

APA

Rebolj, M., Rask, J., van Ballegooijen, M., Kirschner, B., Rozemeijer, K., Bonde, J., ... Lynge, E. (2015). Cervical histology after routine ThinPrep or SurePath liquid-based cytology and computer-assisted reading in Denmark. B J C, 113(9), 1259-74. https://doi.org/10.1038/bjc.2015.339

Vancouver

Rebolj M, Rask J, van Ballegooijen M, Kirschner B, Rozemeijer K, Bonde J et al. Cervical histology after routine ThinPrep or SurePath liquid-based cytology and computer-assisted reading in Denmark. B J C. 2015;113(9):1259-74. https://doi.org/10.1038/bjc.2015.339

Author

Rebolj, Matejka ; Rask, Johanne ; van Ballegooijen, Marjolein ; Kirschner, Benny ; Rozemeijer, Kirsten ; Bonde, Jesper ; Rygaard, Carsten ; Lynge, Elsebeth. / Cervical histology after routine ThinPrep or SurePath liquid-based cytology and computer-assisted reading in Denmark. In: B J C. 2015 ; Vol. 113, No. 9. pp. 1259-74.

Bibtex

@article{c88a3197acb54c59b0103e59fbaebe82,
title = "Cervical histology after routine ThinPrep or SurePath liquid-based cytology and computer-assisted reading in Denmark",
abstract = "BACKGROUND: We compared the sensitivity and specificity of liquid-based cytology (LBC) and computer-assisted reading for SurePath/FocalPoint and ThinPrep with those of manually read conventional cytology in routine cervical screening in four Danish laboratories.METHODS: Using data from five nationwide registers, technological phases were identified by slide preparation, reading technique, and triage of borderline cytology. Trends in the detection of cervical intraepithelial neoplasia (CIN) were an indicator of the technology's relative sensitivity, and trends in false-positive tests an indicator of relative specificity.RESULTS: At 23-29 years, SurePath/FocalPoint statistically significantly increased the detection of ⩾CIN3 by 85{\%} compared with manually read conventional cytology. The 11{\%} increase with ThinPrep was not significant. At 30-44 years, the increase with SurePath/FocalPoint was 58{\%}; the 16{\%} increase with ThinPrep was not significant. At 45-59 years, both technologies led to nonsignificant decreases in the detection. SurePath/FocalPoint doubled the frequency of false-positive tests at any age. With ThinPrep, these proportions remained the same at 23-29 years, but decreased by two-thirds at 45-59 years. In a fourth laboratory with continuous use of manually read conventional cytology, no such trends were seen.CONCLUSIONS: The sensitivity and specificity of modern LBC and computer-assisted reading technologies may be brand- and age-dependent.",
keywords = "Adult, Cervical Intraepithelial Neoplasia, Cervix Uteri, Cytodiagnosis, Denmark, False Positive Reactions, Female, Humans, Middle Aged, Sensitivity and Specificity, Uterine Cervical Neoplasms, Vaginal Smears, Young Adult",
author = "Matejka Rebolj and Johanne Rask and {van Ballegooijen}, Marjolein and Benny Kirschner and Kirsten Rozemeijer and Jesper Bonde and Carsten Rygaard and Elsebeth Lynge",
year = "2015",
doi = "10.1038/bjc.2015.339",
language = "English",
volume = "113",
pages = "1259--74",
journal = "B J C",
issn = "0007-0920",
publisher = "nature publishing group",
number = "9",

}

RIS

TY - JOUR

T1 - Cervical histology after routine ThinPrep or SurePath liquid-based cytology and computer-assisted reading in Denmark

AU - Rebolj, Matejka

AU - Rask, Johanne

AU - van Ballegooijen, Marjolein

AU - Kirschner, Benny

AU - Rozemeijer, Kirsten

AU - Bonde, Jesper

AU - Rygaard, Carsten

AU - Lynge, Elsebeth

PY - 2015

Y1 - 2015

N2 - BACKGROUND: We compared the sensitivity and specificity of liquid-based cytology (LBC) and computer-assisted reading for SurePath/FocalPoint and ThinPrep with those of manually read conventional cytology in routine cervical screening in four Danish laboratories.METHODS: Using data from five nationwide registers, technological phases were identified by slide preparation, reading technique, and triage of borderline cytology. Trends in the detection of cervical intraepithelial neoplasia (CIN) were an indicator of the technology's relative sensitivity, and trends in false-positive tests an indicator of relative specificity.RESULTS: At 23-29 years, SurePath/FocalPoint statistically significantly increased the detection of ⩾CIN3 by 85% compared with manually read conventional cytology. The 11% increase with ThinPrep was not significant. At 30-44 years, the increase with SurePath/FocalPoint was 58%; the 16% increase with ThinPrep was not significant. At 45-59 years, both technologies led to nonsignificant decreases in the detection. SurePath/FocalPoint doubled the frequency of false-positive tests at any age. With ThinPrep, these proportions remained the same at 23-29 years, but decreased by two-thirds at 45-59 years. In a fourth laboratory with continuous use of manually read conventional cytology, no such trends were seen.CONCLUSIONS: The sensitivity and specificity of modern LBC and computer-assisted reading technologies may be brand- and age-dependent.

AB - BACKGROUND: We compared the sensitivity and specificity of liquid-based cytology (LBC) and computer-assisted reading for SurePath/FocalPoint and ThinPrep with those of manually read conventional cytology in routine cervical screening in four Danish laboratories.METHODS: Using data from five nationwide registers, technological phases were identified by slide preparation, reading technique, and triage of borderline cytology. Trends in the detection of cervical intraepithelial neoplasia (CIN) were an indicator of the technology's relative sensitivity, and trends in false-positive tests an indicator of relative specificity.RESULTS: At 23-29 years, SurePath/FocalPoint statistically significantly increased the detection of ⩾CIN3 by 85% compared with manually read conventional cytology. The 11% increase with ThinPrep was not significant. At 30-44 years, the increase with SurePath/FocalPoint was 58%; the 16% increase with ThinPrep was not significant. At 45-59 years, both technologies led to nonsignificant decreases in the detection. SurePath/FocalPoint doubled the frequency of false-positive tests at any age. With ThinPrep, these proportions remained the same at 23-29 years, but decreased by two-thirds at 45-59 years. In a fourth laboratory with continuous use of manually read conventional cytology, no such trends were seen.CONCLUSIONS: The sensitivity and specificity of modern LBC and computer-assisted reading technologies may be brand- and age-dependent.

KW - Adult

KW - Cervical Intraepithelial Neoplasia

KW - Cervix Uteri

KW - Cytodiagnosis

KW - Denmark

KW - False Positive Reactions

KW - Female

KW - Humans

KW - Middle Aged

KW - Sensitivity and Specificity

KW - Uterine Cervical Neoplasms

KW - Vaginal Smears

KW - Young Adult

U2 - 10.1038/bjc.2015.339

DO - 10.1038/bjc.2015.339

M3 - Journal article

C2 - 26448176

VL - 113

SP - 1259

EP - 1274

JO - B J C

JF - B J C

SN - 0007-0920

IS - 9

ER -

ID: 161847937