Checking Fine and Gray subdistribution hazards model with cumulative sums of residuals

Research output: Contribution to journalJournal articleResearchpeer-review

Recently, Fine and Gray (J Am Stat Assoc 94:496–509, 1999) proposed a semi-parametric proportional regression model for the subdistribution hazard function which has been used extensively for analyzing competing risks data. However, failure of model adequacy could lead to severe bias in parameter estimation, and only a limited contribution has been made to check the model assumptions. In this paper, we present a class of analytical methods and graphical approaches for checking the assumptions of Fine and Gray’s model. The proposed goodness-of-fit test procedures are based on the cumulative sums of residuals, which validate the model in three aspects: (1) proportionality of hazard ratio, (2) the linear functional form and (3) the link function. For each assumption testing, we provide a p-values and a visualized plot against the null hypothesis using a simulation-based approach. We also consider an omnibus test for overall evaluation against any model misspecification. The proposed tests perform well in simulation studies and are illustrated with two real data examples.

Original languageEnglish
JournalLifetime Data Analysis
Volume21
Issue number2
Pages (from-to)197-217
Number of pages21
ISSN1380-7870
DOIs
Publication statusPublished - Apr 2015

    Research areas

  • Competing risk, Cumulative residual, Goodness-of-fit, Link function, Omnibus test, Proportional subdistribution hazard

ID: 135266805