Childcare attendance and risk of infectious mononucleosis: A population-based Danish cohort study

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Standard

Childcare attendance and risk of infectious mononucleosis : A population-based Danish cohort study. / Rostgaard, Klaus; Stensballe, Lone Graff; Søegaard, Signe Holst; Kamper-Jørgensen, Mads; Hjalgrim, Henrik.

In: PLoS ONE, Vol. 16, No. 12, e0261665, 2021.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Rostgaard, K, Stensballe, LG, Søegaard, SH, Kamper-Jørgensen, M & Hjalgrim, H 2021, 'Childcare attendance and risk of infectious mononucleosis: A population-based Danish cohort study', PLoS ONE, vol. 16, no. 12, e0261665. https://doi.org/10.1371/journal.pone.0261665

APA

Rostgaard, K., Stensballe, L. G., Søegaard, S. H., Kamper-Jørgensen, M., & Hjalgrim, H. (2021). Childcare attendance and risk of infectious mononucleosis: A population-based Danish cohort study. PLoS ONE, 16(12), [e0261665]. https://doi.org/10.1371/journal.pone.0261665

Vancouver

Rostgaard K, Stensballe LG, Søegaard SH, Kamper-Jørgensen M, Hjalgrim H. Childcare attendance and risk of infectious mononucleosis: A population-based Danish cohort study. PLoS ONE. 2021;16(12). e0261665. https://doi.org/10.1371/journal.pone.0261665

Author

Rostgaard, Klaus ; Stensballe, Lone Graff ; Søegaard, Signe Holst ; Kamper-Jørgensen, Mads ; Hjalgrim, Henrik. / Childcare attendance and risk of infectious mononucleosis : A population-based Danish cohort study. In: PLoS ONE. 2021 ; Vol. 16, No. 12.

Bibtex

@article{4c81b40d5169424685c8e185a09b83ef,
title = "Childcare attendance and risk of infectious mononucleosis: A population-based Danish cohort study",
abstract = "BACKGROUND: The risk of infectious mononucleosis (IM) is affected both by crowding and by sibship structure, i.e., number and signed age differential between an index child and a sibling. Siblings provide protection against IM by pre-empting delayed primary Epstein-Barr virus infection with its associated high risk of IM. The association between childcare attendance and risk of IM, on the other hand, has never been studied in a large, well-characterized cohort.METHODS: Danish children born in July 1992 through 2016 with a completely known simple childcare attendance history before age 1.5 years (n = 908,866) were followed up for a hospital contact with an IM diagnosis at ages 1.5-26 years. Hazard ratios (HRs) of IM for an additional year of exposure were obtained from stratified Cox regression analyses, stratified by sex and year of birth, with age as the underlying time scale, adjusted for sibship structure, and sociodemographic variables including parental ethnicity and maternal age.RESULTS: An additional year of exclusively attending a daycare home (max 5 children) yielded HR = 0.90 (95% confidence interval 0.81-1.00), and similarly, each year of exclusively attending a childcare institution (e.g., cr{\`e}che) yielded HR = 0.94 (0.84-1.06).CONCLUSIONS: Forwarding enrollment in childcare by a year lowers the risk of IM later in life much less than having an additional sibling of comparable age and has no practical public health implications. We find our results suggestive of a random threshold for successful Epstein-Barr virus infection that is more easily reached by a sibling than the collective of playmates in daycare homes or childcare institutions.",
author = "Klaus Rostgaard and Stensballe, {Lone Graff} and S{\o}egaard, {Signe Holst} and Mads Kamper-J{\o}rgensen and Henrik Hjalgrim",
year = "2021",
doi = "10.1371/journal.pone.0261665",
language = "English",
volume = "16",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "12",

}

RIS

TY - JOUR

T1 - Childcare attendance and risk of infectious mononucleosis

T2 - A population-based Danish cohort study

AU - Rostgaard, Klaus

AU - Stensballe, Lone Graff

AU - Søegaard, Signe Holst

AU - Kamper-Jørgensen, Mads

AU - Hjalgrim, Henrik

PY - 2021

Y1 - 2021

N2 - BACKGROUND: The risk of infectious mononucleosis (IM) is affected both by crowding and by sibship structure, i.e., number and signed age differential between an index child and a sibling. Siblings provide protection against IM by pre-empting delayed primary Epstein-Barr virus infection with its associated high risk of IM. The association between childcare attendance and risk of IM, on the other hand, has never been studied in a large, well-characterized cohort.METHODS: Danish children born in July 1992 through 2016 with a completely known simple childcare attendance history before age 1.5 years (n = 908,866) were followed up for a hospital contact with an IM diagnosis at ages 1.5-26 years. Hazard ratios (HRs) of IM for an additional year of exposure were obtained from stratified Cox regression analyses, stratified by sex and year of birth, with age as the underlying time scale, adjusted for sibship structure, and sociodemographic variables including parental ethnicity and maternal age.RESULTS: An additional year of exclusively attending a daycare home (max 5 children) yielded HR = 0.90 (95% confidence interval 0.81-1.00), and similarly, each year of exclusively attending a childcare institution (e.g., crèche) yielded HR = 0.94 (0.84-1.06).CONCLUSIONS: Forwarding enrollment in childcare by a year lowers the risk of IM later in life much less than having an additional sibling of comparable age and has no practical public health implications. We find our results suggestive of a random threshold for successful Epstein-Barr virus infection that is more easily reached by a sibling than the collective of playmates in daycare homes or childcare institutions.

AB - BACKGROUND: The risk of infectious mononucleosis (IM) is affected both by crowding and by sibship structure, i.e., number and signed age differential between an index child and a sibling. Siblings provide protection against IM by pre-empting delayed primary Epstein-Barr virus infection with its associated high risk of IM. The association between childcare attendance and risk of IM, on the other hand, has never been studied in a large, well-characterized cohort.METHODS: Danish children born in July 1992 through 2016 with a completely known simple childcare attendance history before age 1.5 years (n = 908,866) were followed up for a hospital contact with an IM diagnosis at ages 1.5-26 years. Hazard ratios (HRs) of IM for an additional year of exposure were obtained from stratified Cox regression analyses, stratified by sex and year of birth, with age as the underlying time scale, adjusted for sibship structure, and sociodemographic variables including parental ethnicity and maternal age.RESULTS: An additional year of exclusively attending a daycare home (max 5 children) yielded HR = 0.90 (95% confidence interval 0.81-1.00), and similarly, each year of exclusively attending a childcare institution (e.g., crèche) yielded HR = 0.94 (0.84-1.06).CONCLUSIONS: Forwarding enrollment in childcare by a year lowers the risk of IM later in life much less than having an additional sibling of comparable age and has no practical public health implications. We find our results suggestive of a random threshold for successful Epstein-Barr virus infection that is more easily reached by a sibling than the collective of playmates in daycare homes or childcare institutions.

U2 - 10.1371/journal.pone.0261665

DO - 10.1371/journal.pone.0261665

M3 - Journal article

C2 - 34937060

VL - 16

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 12

M1 - e0261665

ER -

ID: 288179607