Childhood asthma is associated with development of type 1 diabetes and inflammatory bowel diseases: a Danish nationwide registry study
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Childhood asthma is associated with development of type 1 diabetes and inflammatory bowel diseases : a Danish nationwide registry study. / Liljendahl, Mie Sylow; Sevelsted, Astrid; Chawes, Bo L.; Stokholm, Jakob; Bønnelykke, Klaus; Andersen, Zorana Jovanovic; Bisgaard, Hans.
In: Scientific Reports, Vol. 12, No. 1, 21728, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Childhood asthma is associated with development of type 1 diabetes and inflammatory bowel diseases
T2 - a Danish nationwide registry study
AU - Liljendahl, Mie Sylow
AU - Sevelsted, Astrid
AU - Chawes, Bo L.
AU - Stokholm, Jakob
AU - Bønnelykke, Klaus
AU - Andersen, Zorana Jovanovic
AU - Bisgaard, Hans
N1 - Publisher Copyright: © 2022, The Author(s).
PY - 2022
Y1 - 2022
N2 - Asthma and autoimmune disorders might be affected by opposing immune mechanisms, T helper cells type 2 (Th2) and T helper cells type 1 (Th1) immunity, respectively. Knowledge on comorbidity can increase understanding of the underlying etiologies. We aim to examine the association between childhood asthma and subsequent risk of type 1 diabetes (T1D) and inflammatory bowel diseases (IBD) in Danish children. Children of Danish origin born during 1991–1996 were included and childhood asthma, defined as a minimum of two collected prescriptions of inhalation corticosteroids age 5–7 years, was linked to hospitalisations with either T1D or IBD after age 8. Associations between childhood asthma and incidence of T1D and IBD were analysed using sex- and year stratified Cox regression. A total of 366,200 children were included in the study, 4.9% had asthma, which increased the risk of both T1D and IBD, hazard ratios of 1.32 (1.08–1.61) and 1.27 (1.09–1.48). In this large nationwide Danish study, we found that children with asthma have increased risk of developing immune diseases T1D and IBD. This contradicts the Th1 vs Th2 paradigm and points towards shared disease mechanisms and risk factors.
AB - Asthma and autoimmune disorders might be affected by opposing immune mechanisms, T helper cells type 2 (Th2) and T helper cells type 1 (Th1) immunity, respectively. Knowledge on comorbidity can increase understanding of the underlying etiologies. We aim to examine the association between childhood asthma and subsequent risk of type 1 diabetes (T1D) and inflammatory bowel diseases (IBD) in Danish children. Children of Danish origin born during 1991–1996 were included and childhood asthma, defined as a minimum of two collected prescriptions of inhalation corticosteroids age 5–7 years, was linked to hospitalisations with either T1D or IBD after age 8. Associations between childhood asthma and incidence of T1D and IBD were analysed using sex- and year stratified Cox regression. A total of 366,200 children were included in the study, 4.9% had asthma, which increased the risk of both T1D and IBD, hazard ratios of 1.32 (1.08–1.61) and 1.27 (1.09–1.48). In this large nationwide Danish study, we found that children with asthma have increased risk of developing immune diseases T1D and IBD. This contradicts the Th1 vs Th2 paradigm and points towards shared disease mechanisms and risk factors.
U2 - 10.1038/s41598-022-26067-4
DO - 10.1038/s41598-022-26067-4
M3 - Journal article
C2 - 36526660
AN - SCOPUS:85144133989
VL - 12
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 21728
ER -
ID: 338354306