Childhood body mass index and height and risk of histologic subtypes of endometrial cancer

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Childhood body mass index and height and risk of histologic subtypes of endometrial cancer. / Aarestrup, J.; Gamborg, M.; Ulrich, L. G.; Sørensen, T. I. A.; Baker, J. L.

In: International Journal of Obesity, Vol. 40, 2016, p. 1096-1102.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Aarestrup, J, Gamborg, M, Ulrich, LG, Sørensen, TIA & Baker, JL 2016, 'Childhood body mass index and height and risk of histologic subtypes of endometrial cancer', International Journal of Obesity, vol. 40, pp. 1096-1102. https://doi.org/10.1038/ijo.2016.56

APA

Aarestrup, J., Gamborg, M., Ulrich, L. G., Sørensen, T. I. A., & Baker, J. L. (2016). Childhood body mass index and height and risk of histologic subtypes of endometrial cancer. International Journal of Obesity, 40, 1096-1102. https://doi.org/10.1038/ijo.2016.56

Vancouver

Aarestrup J, Gamborg M, Ulrich LG, Sørensen TIA, Baker JL. Childhood body mass index and height and risk of histologic subtypes of endometrial cancer. International Journal of Obesity. 2016;40:1096-1102. https://doi.org/10.1038/ijo.2016.56

Author

Aarestrup, J. ; Gamborg, M. ; Ulrich, L. G. ; Sørensen, T. I. A. ; Baker, J. L. / Childhood body mass index and height and risk of histologic subtypes of endometrial cancer. In: International Journal of Obesity. 2016 ; Vol. 40. pp. 1096-1102.

Bibtex

@article{f104b05e3a474a2f8184b6b312fbbe44,
title = "Childhood body mass index and height and risk of histologic subtypes of endometrial cancer",
abstract = "BACKGROUND: Endometrial cancer risk factors include adult obesity and taller stature, but the influence of size earlier in life is incompletely understood. We examined whether childhood body mass index (BMI; kg m(-2)) and height were associated with histologic subtypes of endometrial cancer.METHODS: From the Copenhagen School Health Records Register, 155 505 girls born 1930-1989 with measured weights and heights from 7 to 13 years were linked to health registers. BMI and height were transformed to age-specific z-scores. Hazard ratios (HRs) and 95{\%} confidence intervals were estimated by Cox regressions.RESULTS: A total of 1020 endometrial cancers were recorded. BMI was non-linearly associated with all endometrial cancers, oestrogen-dependent cancers and the subtype of endometrioid adenocarcinomas; associations were statistically significant and positive above a z-score=0 and non-significant below zero. Compared with a 7-year-old girl with a BMI z-score=0, an equally tall girl who was 3.6 kg heavier (BMI z-score=1.5) had a hazard ratio=1.53 (95{\%} confidence interval: 1.29-1.82) for endometrioid adenocarcinoma. BMI was not associated with non-oestrogen-dependent cancers, except at the oldest childhood ages. Height at all ages was statistically significant and positively associated with all endometrial cancers, except non-oestrogen-dependent cancers. At 7 years, per ~5.2 cm (1 z-score), the risk of endometrioid adenocarcinoma was 1.18 (95{\%} confidence interval: 1.09-1.28). Among non-users of unopposed oestrogens, associations between BMI and endometrioid adenocarcinoma strengthened, but no effects on height associations were observed.CONCLUSIONS: Endometrial carcinogenesis is linked to early-life body size, suggesting that childhood BMI and height may be useful indicators for the risk of later development of endometrial cancer and might aid in the early prevention of obesity-related endometrial cancers.",
keywords = "Journal Article",
author = "J. Aarestrup and M. Gamborg and Ulrich, {L. G.} and S{\o}rensen, {T. I. A.} and Baker, {J. L.}",
year = "2016",
doi = "10.1038/ijo.2016.56",
language = "English",
volume = "40",
pages = "1096--1102",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Childhood body mass index and height and risk of histologic subtypes of endometrial cancer

AU - Aarestrup, J.

AU - Gamborg, M.

AU - Ulrich, L. G.

AU - Sørensen, T. I. A.

AU - Baker, J. L.

PY - 2016

Y1 - 2016

N2 - BACKGROUND: Endometrial cancer risk factors include adult obesity and taller stature, but the influence of size earlier in life is incompletely understood. We examined whether childhood body mass index (BMI; kg m(-2)) and height were associated with histologic subtypes of endometrial cancer.METHODS: From the Copenhagen School Health Records Register, 155 505 girls born 1930-1989 with measured weights and heights from 7 to 13 years were linked to health registers. BMI and height were transformed to age-specific z-scores. Hazard ratios (HRs) and 95% confidence intervals were estimated by Cox regressions.RESULTS: A total of 1020 endometrial cancers were recorded. BMI was non-linearly associated with all endometrial cancers, oestrogen-dependent cancers and the subtype of endometrioid adenocarcinomas; associations were statistically significant and positive above a z-score=0 and non-significant below zero. Compared with a 7-year-old girl with a BMI z-score=0, an equally tall girl who was 3.6 kg heavier (BMI z-score=1.5) had a hazard ratio=1.53 (95% confidence interval: 1.29-1.82) for endometrioid adenocarcinoma. BMI was not associated with non-oestrogen-dependent cancers, except at the oldest childhood ages. Height at all ages was statistically significant and positively associated with all endometrial cancers, except non-oestrogen-dependent cancers. At 7 years, per ~5.2 cm (1 z-score), the risk of endometrioid adenocarcinoma was 1.18 (95% confidence interval: 1.09-1.28). Among non-users of unopposed oestrogens, associations between BMI and endometrioid adenocarcinoma strengthened, but no effects on height associations were observed.CONCLUSIONS: Endometrial carcinogenesis is linked to early-life body size, suggesting that childhood BMI and height may be useful indicators for the risk of later development of endometrial cancer and might aid in the early prevention of obesity-related endometrial cancers.

AB - BACKGROUND: Endometrial cancer risk factors include adult obesity and taller stature, but the influence of size earlier in life is incompletely understood. We examined whether childhood body mass index (BMI; kg m(-2)) and height were associated with histologic subtypes of endometrial cancer.METHODS: From the Copenhagen School Health Records Register, 155 505 girls born 1930-1989 with measured weights and heights from 7 to 13 years were linked to health registers. BMI and height were transformed to age-specific z-scores. Hazard ratios (HRs) and 95% confidence intervals were estimated by Cox regressions.RESULTS: A total of 1020 endometrial cancers were recorded. BMI was non-linearly associated with all endometrial cancers, oestrogen-dependent cancers and the subtype of endometrioid adenocarcinomas; associations were statistically significant and positive above a z-score=0 and non-significant below zero. Compared with a 7-year-old girl with a BMI z-score=0, an equally tall girl who was 3.6 kg heavier (BMI z-score=1.5) had a hazard ratio=1.53 (95% confidence interval: 1.29-1.82) for endometrioid adenocarcinoma. BMI was not associated with non-oestrogen-dependent cancers, except at the oldest childhood ages. Height at all ages was statistically significant and positively associated with all endometrial cancers, except non-oestrogen-dependent cancers. At 7 years, per ~5.2 cm (1 z-score), the risk of endometrioid adenocarcinoma was 1.18 (95% confidence interval: 1.09-1.28). Among non-users of unopposed oestrogens, associations between BMI and endometrioid adenocarcinoma strengthened, but no effects on height associations were observed.CONCLUSIONS: Endometrial carcinogenesis is linked to early-life body size, suggesting that childhood BMI and height may be useful indicators for the risk of later development of endometrial cancer and might aid in the early prevention of obesity-related endometrial cancers.

KW - Journal Article

U2 - 10.1038/ijo.2016.56

DO - 10.1038/ijo.2016.56

M3 - Journal article

VL - 40

SP - 1096

EP - 1102

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

ER -

ID: 166944862