Childhood motor coordination and adult schizophrenia spectrum disorders
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Childhood motor coordination and adult schizophrenia spectrum disorders. / Schiffman, Jason; Sorensen, Holger J; Maeda, Justin; Mortensen, Erik Lykke; Victoroff, Jeff; Hayashi, Kentaro; Michelsen, Niels M; Ekstrom, Morten; Mednick, Sarnoff; Schiffman, Jason; Sørensen, Holger Jelling; Maeda, Justin; Mortensen, Erik L; Victoroff, Jeff; Hayashi, Kentaro; Michelsen, Niels M; Ekstrøm, Morten; Mednick, Sarnoff.
In: American Journal of Psychiatry, Vol. 166, No. 9, 2009, p. 1041-7.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Childhood motor coordination and adult schizophrenia spectrum disorders
AU - Schiffman, Jason
AU - Sorensen, Holger J
AU - Maeda, Justin
AU - Mortensen, Erik Lykke
AU - Victoroff, Jeff
AU - Hayashi, Kentaro
AU - Michelsen, Niels M
AU - Ekstrom, Morten
AU - Mednick, Sarnoff
AU - Schiffman, Jason
AU - Sørensen, Holger Jelling
AU - Maeda, Justin
AU - Mortensen, Erik L
AU - Victoroff, Jeff
AU - Hayashi, Kentaro
AU - Michelsen, Niels M
AU - Ekstrøm, Morten
AU - Mednick, Sarnoff
N1 - Keywords: Adult; Basal Ganglia; Cerebellum; Child; Child of Impaired Parents; Denmark; Fathers; Female; Hospitalization; Hospitals, Psychiatric; Humans; Male; Mental Disorders; Mothers; Motor Skills Disorders; Neurologic Examination; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology
PY - 2009
Y1 - 2009
N2 - OBJECTIVE: The authors examined whether motor coordination difficulties assessed in childhood predict later adult schizophrenia spectrum outcomes. METHOD: A standardized childhood neurological examination was administered to a sample of 265 Danish children in 1972, when participants were 10-13 years old. Adult diagnostic information was available for 244 members of the sample. Participants fell into three groups: children whose mothers or fathers had a psychiatric hospital diagnosis of schizophrenia (N=94); children who had at least one parent with a psychiatric record of hospitalization for a nonpsychotic disorder (N=84); and children with no parental records of psychiatric hospitalization (N=66). Psychiatric outcomes of the offspring were assessed through psychiatric interviews in 1992 when participants were 31-33 years of age, as well as through a scan of national psychiatric registers completed in May 2007. RESULTS: Children who later developed a schizophrenia spectrum disorder (N=32) displayed significantly higher scores on a scale of coordination deficits compared with those who did not develop a mental illness in this category (N=133). CONCLUSIONS: Results from this study provide further support for the neurodevelopmental hypothesis of schizophrenia and underscore the potential role of cerebellar and/or basal ganglia abnormalities in the etiology and pathophysiology of schizophrenia.
AB - OBJECTIVE: The authors examined whether motor coordination difficulties assessed in childhood predict later adult schizophrenia spectrum outcomes. METHOD: A standardized childhood neurological examination was administered to a sample of 265 Danish children in 1972, when participants were 10-13 years old. Adult diagnostic information was available for 244 members of the sample. Participants fell into three groups: children whose mothers or fathers had a psychiatric hospital diagnosis of schizophrenia (N=94); children who had at least one parent with a psychiatric record of hospitalization for a nonpsychotic disorder (N=84); and children with no parental records of psychiatric hospitalization (N=66). Psychiatric outcomes of the offspring were assessed through psychiatric interviews in 1992 when participants were 31-33 years of age, as well as through a scan of national psychiatric registers completed in May 2007. RESULTS: Children who later developed a schizophrenia spectrum disorder (N=32) displayed significantly higher scores on a scale of coordination deficits compared with those who did not develop a mental illness in this category (N=133). CONCLUSIONS: Results from this study provide further support for the neurodevelopmental hypothesis of schizophrenia and underscore the potential role of cerebellar and/or basal ganglia abnormalities in the etiology and pathophysiology of schizophrenia.
U2 - 10.1176/appi.ajp.2009.08091400
DO - 10.1176/appi.ajp.2009.08091400
M3 - Journal article
C2 - 19605535
VL - 166
SP - 1041
EP - 1047
JO - The American Journal of Psychiatry
JF - The American Journal of Psychiatry
SN - 0002-953X
IS - 9
ER -
ID: 14913209