Clinical drug development using dynamic biomarkers to enable personalized health care in Chronic Obstructive Pulmonary Disease

Research output: Contribution to journal › Review › Research › peer-review

Standard

Clinical drug development using dynamic biomarkers to enable personalized health care in Chronic Obstructive Pulmonary Disease. / Bihlet, Asger R; Karsdal, Morten A; Bay-Jensen, Anne-Christine; Read, Simon; Kristensen, Jacob Hull; Sand, Jannie Marie Bülow; Leeming, Diana Julie; Andersen, Jeppe Ragnar; Lange, Peter; Vestbo, Jørgen.

In: Chest, Vol. 148, No. 1, 07.2015, p. 16-23.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Bihlet, AR, Karsdal, MA, Bay-Jensen, A-C, Read, S, Kristensen, JH, Sand, JMB, Leeming, DJ, Andersen, JR, Lange, P & Vestbo, J 2015, 'Clinical drug development using dynamic biomarkers to enable personalized health care in Chronic Obstructive Pulmonary Disease', Chest, vol. 148, no. 1, pp. 16-23. https://doi.org/10.1378/chest.15-0296

APA

Bihlet, A. R., Karsdal, M. A., Bay-Jensen, A-C., Read, S., Kristensen, J. H., Sand, J. M. B., Leeming, D. J., Andersen, J. R., Lange, P., & Vestbo, J. (2015). Clinical drug development using dynamic biomarkers to enable personalized health care in Chronic Obstructive Pulmonary Disease. Chest, 148(1), 16-23. https://doi.org/10.1378/chest.15-0296

Vancouver

Bihlet AR, Karsdal MA, Bay-Jensen A-C, Read S, Kristensen JH, Sand JMB et al. Clinical drug development using dynamic biomarkers to enable personalized health care in Chronic Obstructive Pulmonary Disease. Chest. 2015 Jul;148(1):16-23. https://doi.org/10.1378/chest.15-0296

Author

Bihlet, Asger R ; Karsdal, Morten A ; Bay-Jensen, Anne-Christine ; Read, Simon ; Kristensen, Jacob Hull ; Sand, Jannie Marie Bülow ; Leeming, Diana Julie ; Andersen, Jeppe Ragnar ; Lange, Peter ; Vestbo, Jørgen. / Clinical drug development using dynamic biomarkers to enable personalized health care in Chronic Obstructive Pulmonary Disease. In: Chest. 2015 ; Vol. 148, No. 1. pp. 16-23.

Bibtex

@article{50b2e62886b049e8a624814af0660733,
title = "Clinical drug development using dynamic biomarkers to enable personalized health care in Chronic Obstructive Pulmonary Disease",
abstract = "Despite massive investments in development of novel treatments for heterogeneous diseases such as Chronic Obstructive Pulmonary Disease (COPD), the resources spent have only benefitted a fraction of the population treated. Personalized Health Care to guide selection of a suitable patient population already in the clinical development of new compounds could offer a solution. In this review, we discuss past successes and failures in drug development and biomarker research in COPD. We describe research in COPD phenotypes, and the required characteristics of a suitable biomarker for identifying patients at higher risk of progression. We review the role of extra-cellular matrix proteins found to be upregulated in COPD. Novel biomarkers of connective tissue remodeling which may provide added value for a personalized approach by detecting subgroups of patients with active disease suitable for pharmacological intervention are discussed.",
author = "Bihlet, {Asger R} and Karsdal, {Morten A} and Anne-Christine Bay-Jensen and Simon Read and Kristensen, {Jacob Hull} and Sand, {Jannie Marie B{\"u}low} and Leeming, {Diana Julie} and Andersen, {Jeppe Ragnar} and Peter Lange and J{\o}rgen Vestbo",
year = "2015",
month = jul,
doi = "10.1378/chest.15-0296",
language = "English",
volume = "148",
pages = "16--23",
journal = "Chest",
issn = "0012-3692",
publisher = "American College of Chest Physicians",
number = "1",

}

RIS

TY - JOUR

T1 - Clinical drug development using dynamic biomarkers to enable personalized health care in Chronic Obstructive Pulmonary Disease

AU - Bihlet, Asger R

AU - Karsdal, Morten A

AU - Bay-Jensen, Anne-Christine

AU - Read, Simon

AU - Kristensen, Jacob Hull

AU - Sand, Jannie Marie Bülow

AU - Leeming, Diana Julie

AU - Andersen, Jeppe Ragnar

AU - Lange, Peter

AU - Vestbo, Jørgen

PY - 2015/7

Y1 - 2015/7

N2 - Despite massive investments in development of novel treatments for heterogeneous diseases such as Chronic Obstructive Pulmonary Disease (COPD), the resources spent have only benefitted a fraction of the population treated. Personalized Health Care to guide selection of a suitable patient population already in the clinical development of new compounds could offer a solution. In this review, we discuss past successes and failures in drug development and biomarker research in COPD. We describe research in COPD phenotypes, and the required characteristics of a suitable biomarker for identifying patients at higher risk of progression. We review the role of extra-cellular matrix proteins found to be upregulated in COPD. Novel biomarkers of connective tissue remodeling which may provide added value for a personalized approach by detecting subgroups of patients with active disease suitable for pharmacological intervention are discussed.

AB - Despite massive investments in development of novel treatments for heterogeneous diseases such as Chronic Obstructive Pulmonary Disease (COPD), the resources spent have only benefitted a fraction of the population treated. Personalized Health Care to guide selection of a suitable patient population already in the clinical development of new compounds could offer a solution. In this review, we discuss past successes and failures in drug development and biomarker research in COPD. We describe research in COPD phenotypes, and the required characteristics of a suitable biomarker for identifying patients at higher risk of progression. We review the role of extra-cellular matrix proteins found to be upregulated in COPD. Novel biomarkers of connective tissue remodeling which may provide added value for a personalized approach by detecting subgroups of patients with active disease suitable for pharmacological intervention are discussed.

U2 - 10.1378/chest.15-0296

DO - 10.1378/chest.15-0296

M3 - Review

C2 - 25856563

VL - 148

SP - 16

EP - 23

JO - Chest

JF - Chest

SN - 0012-3692

IS - 1

ER -

ID: 135784413