Cognitive function is related to fronto-striatal serotonin transporter levels--a brain PET study in young healthy subjects
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Cognitive function is related to fronto-striatal serotonin transporter levels--a brain PET study in young healthy subjects. / Madsen, Karine; Erritzøe, David Frederik; Mortensen, Erik Lykke; Gade, Anders; Madsen, Jacob; Baaré, William Frans Christiaan; Knudsen, Gitte M; Hasselbalch, Steen G.
In: Psychopharmacology, Vol. 213, No. 2-3, 01.02.2011, p. 573-81.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Cognitive function is related to fronto-striatal serotonin transporter levels--a brain PET study in young healthy subjects
AU - Madsen, Karine
AU - Erritzøe, David Frederik
AU - Mortensen, Erik Lykke
AU - Gade, Anders
AU - Madsen, Jacob
AU - Baaré, William Frans Christiaan
AU - Knudsen, Gitte M
AU - Hasselbalch, Steen G
PY - 2011/2/1
Y1 - 2011/2/1
N2 - Pharmacological manipulation of serotonergic neurotransmission in healthy volunteers impacts on cognitive test performance. Specifically, markers of serotonin function are associated with attention and executive functioning, long-term memory, and general cognitive ability. The serotonin transporter (SERT) protein is a key regulator in the serotonin system. We hypothesized that higher performance on tests sensitive to serotonin would be associated with higher SERT levels in specific fronto-striatal brain regions.
AB - Pharmacological manipulation of serotonergic neurotransmission in healthy volunteers impacts on cognitive test performance. Specifically, markers of serotonin function are associated with attention and executive functioning, long-term memory, and general cognitive ability. The serotonin transporter (SERT) protein is a key regulator in the serotonin system. We hypothesized that higher performance on tests sensitive to serotonin would be associated with higher SERT levels in specific fronto-striatal brain regions.
U2 - 10.1007/s00213-010-1926-4
DO - 10.1007/s00213-010-1926-4
M3 - Journal article
C2 - 20623110
VL - 213
SP - 573
EP - 581
JO - Psychopharmacology
JF - Psychopharmacology
SN - 0033-3158
IS - 2-3
ER -
ID: 33183939