Comparison of antibiotic prescribing and antimicrobial resistance in urinary tract infections at the municipal level among women in two Nordic regions

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Comparison of antibiotic prescribing and antimicrobial resistance in urinary tract infections at the municipal level among women in two Nordic regions. / Nygaard Jensen, Jette; Melander, Eva; Hedin, Katarina; Bjerrum, Lars; Kornfält Isberg, Helena; Holm, Anne; Neel Jacobsen, Helle; Skovby, Annette; Córdoba Currea, Gloria Cristina; Hyllebusk, Lena; Brogaard, Emma; Arpi, Magnus.

In: The Journal of antimicrobial chemotherapy, Vol. 73, No. 8, 2018, p. 2207-2214.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Nygaard Jensen, J, Melander, E, Hedin, K, Bjerrum, L, Kornfält Isberg, H, Holm, A, Neel Jacobsen, H, Skovby, A, Córdoba Currea, GC, Hyllebusk, L, Brogaard, E & Arpi, M 2018, 'Comparison of antibiotic prescribing and antimicrobial resistance in urinary tract infections at the municipal level among women in two Nordic regions', The Journal of antimicrobial chemotherapy, vol. 73, no. 8, pp. 2207-2214. https://doi.org/10.1093/jac/dky177

APA

Nygaard Jensen, J., Melander, E., Hedin, K., Bjerrum, L., Kornfält Isberg, H., Holm, A., ... Arpi, M. (2018). Comparison of antibiotic prescribing and antimicrobial resistance in urinary tract infections at the municipal level among women in two Nordic regions. The Journal of antimicrobial chemotherapy, 73(8), 2207-2214. https://doi.org/10.1093/jac/dky177

Vancouver

Nygaard Jensen J, Melander E, Hedin K, Bjerrum L, Kornfält Isberg H, Holm A et al. Comparison of antibiotic prescribing and antimicrobial resistance in urinary tract infections at the municipal level among women in two Nordic regions. The Journal of antimicrobial chemotherapy. 2018;73(8):2207-2214. https://doi.org/10.1093/jac/dky177

Author

Nygaard Jensen, Jette ; Melander, Eva ; Hedin, Katarina ; Bjerrum, Lars ; Kornfält Isberg, Helena ; Holm, Anne ; Neel Jacobsen, Helle ; Skovby, Annette ; Córdoba Currea, Gloria Cristina ; Hyllebusk, Lena ; Brogaard, Emma ; Arpi, Magnus. / Comparison of antibiotic prescribing and antimicrobial resistance in urinary tract infections at the municipal level among women in two Nordic regions. In: The Journal of antimicrobial chemotherapy. 2018 ; Vol. 73, No. 8. pp. 2207-2214.

Bibtex

@article{fa755765414f4b4ba77d832ff3cd45bc,
title = "Comparison of antibiotic prescribing and antimicrobial resistance in urinary tract infections at the municipal level among women in two Nordic regions",
abstract = "Objectives: To describe and compare the prescribing of antibiotics used for urinary tract infections and its correlation with resistance in Escherichia coli in urinary samples across two adjacent regions-the Capital Region and the Skaane Region-and their municipalities in Denmark and Sweden.Methods: The Capital Region consists of 29 municipalities and 725 960 female inhabitants aged ≥18 years and the Skaane Region consists of 33 municipalities and 515 668 female inhabitants aged ≥18 years. Aggregated data from outpatient care on the prescribing of pivmecillinam, trimethoprim and nitrofurantoin from both regions were analysed. The Department of Clinical Microbiology in both regions provided data on E. coli resistance in urinary samples from women aged ≥18 years. Data were measured as the number of prescriptions/1000 women/year, number of DDDs/1000 women/year and DDDs/prescription. Correlation analyses between antibiotic prescribing and antibiotic resistance rates were performed.Results: Antibiotic prescribing and resistance rates were significantly higher in the Capital Region compared with the Skaane Region. Large variations in prescription and resistance rates were found at the municipal level, but there were no correlations between the antibiotic prescription and resistance rates when each region was analysed separately.Conclusions: Although closely related, there are large differences in antibiotic prescribing and antibiotic resistance. It is suggested that the regional guidelines are an important driver and explanatory factor for the variations; however, further research is needed in this new field and factors such as the influence of cultural aspects should be the target of further research.",
author = "{Nygaard Jensen}, Jette and Eva Melander and Katarina Hedin and Lars Bjerrum and {Kornf{\"a}lt Isberg}, Helena and Anne Holm and {Neel Jacobsen}, Helle and Annette Skovby and {C{\'o}rdoba Currea}, {Gloria Cristina} and Lena Hyllebusk and Emma Brogaard and Magnus Arpi",
year = "2018",
doi = "10.1093/jac/dky177",
language = "English",
volume = "73",
pages = "2207--2214",
journal = "Journal of Antimicrobial Chemotherapy",
issn = "0305-7453",
publisher = "Oxford University Press",
number = "8",

}

RIS

TY - JOUR

T1 - Comparison of antibiotic prescribing and antimicrobial resistance in urinary tract infections at the municipal level among women in two Nordic regions

AU - Nygaard Jensen, Jette

AU - Melander, Eva

AU - Hedin, Katarina

AU - Bjerrum, Lars

AU - Kornfält Isberg, Helena

AU - Holm, Anne

AU - Neel Jacobsen, Helle

AU - Skovby, Annette

AU - Córdoba Currea, Gloria Cristina

AU - Hyllebusk, Lena

AU - Brogaard, Emma

AU - Arpi, Magnus

PY - 2018

Y1 - 2018

N2 - Objectives: To describe and compare the prescribing of antibiotics used for urinary tract infections and its correlation with resistance in Escherichia coli in urinary samples across two adjacent regions-the Capital Region and the Skaane Region-and their municipalities in Denmark and Sweden.Methods: The Capital Region consists of 29 municipalities and 725 960 female inhabitants aged ≥18 years and the Skaane Region consists of 33 municipalities and 515 668 female inhabitants aged ≥18 years. Aggregated data from outpatient care on the prescribing of pivmecillinam, trimethoprim and nitrofurantoin from both regions were analysed. The Department of Clinical Microbiology in both regions provided data on E. coli resistance in urinary samples from women aged ≥18 years. Data were measured as the number of prescriptions/1000 women/year, number of DDDs/1000 women/year and DDDs/prescription. Correlation analyses between antibiotic prescribing and antibiotic resistance rates were performed.Results: Antibiotic prescribing and resistance rates were significantly higher in the Capital Region compared with the Skaane Region. Large variations in prescription and resistance rates were found at the municipal level, but there were no correlations between the antibiotic prescription and resistance rates when each region was analysed separately.Conclusions: Although closely related, there are large differences in antibiotic prescribing and antibiotic resistance. It is suggested that the regional guidelines are an important driver and explanatory factor for the variations; however, further research is needed in this new field and factors such as the influence of cultural aspects should be the target of further research.

AB - Objectives: To describe and compare the prescribing of antibiotics used for urinary tract infections and its correlation with resistance in Escherichia coli in urinary samples across two adjacent regions-the Capital Region and the Skaane Region-and their municipalities in Denmark and Sweden.Methods: The Capital Region consists of 29 municipalities and 725 960 female inhabitants aged ≥18 years and the Skaane Region consists of 33 municipalities and 515 668 female inhabitants aged ≥18 years. Aggregated data from outpatient care on the prescribing of pivmecillinam, trimethoprim and nitrofurantoin from both regions were analysed. The Department of Clinical Microbiology in both regions provided data on E. coli resistance in urinary samples from women aged ≥18 years. Data were measured as the number of prescriptions/1000 women/year, number of DDDs/1000 women/year and DDDs/prescription. Correlation analyses between antibiotic prescribing and antibiotic resistance rates were performed.Results: Antibiotic prescribing and resistance rates were significantly higher in the Capital Region compared with the Skaane Region. Large variations in prescription and resistance rates were found at the municipal level, but there were no correlations between the antibiotic prescription and resistance rates when each region was analysed separately.Conclusions: Although closely related, there are large differences in antibiotic prescribing and antibiotic resistance. It is suggested that the regional guidelines are an important driver and explanatory factor for the variations; however, further research is needed in this new field and factors such as the influence of cultural aspects should be the target of further research.

U2 - 10.1093/jac/dky177

DO - 10.1093/jac/dky177

M3 - Journal article

C2 - 29757408

VL - 73

SP - 2207

EP - 2214

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

SN - 0305-7453

IS - 8

ER -

ID: 198610950