Correlates of serum IGF-1 in young children with moderate acute malnutrition: a cross-sectional study in Burkina Faso

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Correlates of serum IGF-1 in young children with moderate acute malnutrition: a cross-sectional study in Burkina Faso. / Kjær, Thora Wesenberg; Grenov, Benedikte; Yaméogo, Charles W; Fabiansen, Christian; Iuel-Brockdorff, Ann-Sophie; Cichon, Bernardette; Nielsen, Nick Schou; Filteau, Suzanne; Briend, André; Wells, Jonathan C K; Michaelsen, Kim F.; Friis, Henrik; Faurholt-Jepsen, Daniel; Christensen, Vibeke Brix.

In: American Journal of Clinical Nutrition, 08.05.2021.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Kjær, TW, Grenov, B, Yaméogo, CW, Fabiansen, C, Iuel-Brockdorff, A-S, Cichon, B, Nielsen, NS, Filteau, S, Briend, A, Wells, JCK, Michaelsen, KF, Friis, H, Faurholt-Jepsen, D & Christensen, VB 2021, 'Correlates of serum IGF-1 in young children with moderate acute malnutrition: a cross-sectional study in Burkina Faso', American Journal of Clinical Nutrition. https://doi.org/10.1093/ajcn/nqab120

APA

Kjær, T. W., Grenov, B., Yaméogo, C. W., Fabiansen, C., Iuel-Brockdorff, A-S., Cichon, B., Nielsen, N. S., Filteau, S., Briend, A., Wells, J. C. K., Michaelsen, K. F., Friis, H., Faurholt-Jepsen, D., & Christensen, V. B. (2021). Correlates of serum IGF-1 in young children with moderate acute malnutrition: a cross-sectional study in Burkina Faso. American Journal of Clinical Nutrition. https://doi.org/10.1093/ajcn/nqab120

Vancouver

Kjær TW, Grenov B, Yaméogo CW, Fabiansen C, Iuel-Brockdorff A-S, Cichon B et al. Correlates of serum IGF-1 in young children with moderate acute malnutrition: a cross-sectional study in Burkina Faso. American Journal of Clinical Nutrition. 2021 May 8. https://doi.org/10.1093/ajcn/nqab120

Author

Kjær, Thora Wesenberg ; Grenov, Benedikte ; Yaméogo, Charles W ; Fabiansen, Christian ; Iuel-Brockdorff, Ann-Sophie ; Cichon, Bernardette ; Nielsen, Nick Schou ; Filteau, Suzanne ; Briend, André ; Wells, Jonathan C K ; Michaelsen, Kim F. ; Friis, Henrik ; Faurholt-Jepsen, Daniel ; Christensen, Vibeke Brix. / Correlates of serum IGF-1 in young children with moderate acute malnutrition: a cross-sectional study in Burkina Faso. In: American Journal of Clinical Nutrition. 2021.

Bibtex

@article{8af2ada6f8a74d36bc9cfc13330f39e3,
title = "Correlates of serum IGF-1 in young children with moderate acute malnutrition: a cross-sectional study in Burkina Faso",
abstract = "Background: Serum insulin-like growth factor 1 (sIGF-1) is an important growth factor in childhood. However, studies on sIGF-1 among children from low-income countries are few, and the role of body composition is unknown.Objectives: To assess the associations of anthropometry, body composition, inflammation, and breastfeeding with sIGF-1 among children with moderate acute malnutrition (MAM).Methods: A cross-sectional study based on admission data from 6- to 23-mo-old children with MAM participating in a nutrition intervention trial (Treatfood) in Burkina Faso. Linear regression analysis was used to identify correlates of sIGF-1.Results: Among 1546 children, the median (IQR) sIGF-1 was 12 (8.2-18.3) ng/mL. sIGF-1 was highest at 6 mo, with a nadir ∼10-11 mo, and higher in girls than boys. Length-for-age z score (LAZ), weight-for-length z score (WLZ), and midupper arm circumference were positively associated with sIGF-1 (P ≤ 0.001). Fat-free mass (FFM) was also positively associated, as sIGF-1 increased 1.5 (95% CI: 0.5, 2.5) ng/mL for each 1-kg increase in FFM. However, the association disappeared after adjustment for height. Elevated serum C-reactive protein and α1-acid glycoprotein were negatively associated with sIGF-1 (P ≤ 0.001), as was fever (P < 0.001) but not a positive malaria test per se (P = 0.15). Children never breastfed had lower sIGF-1 (-5.1; 95% CI: -9.8, -0.3).Conclusions: LAZ and WLZ were positively and inflammation negatively associated with sIGF-1. As all children were moderately malnourished and many had inflammation, this probably explains the very low median sIGF-1. The association of FFM with sIGF-1 was fully explained by height. There was a marked age pattern, with a nadir in late infancy, confirming findings from smaller studies from well-nourished populations. There is a need for prospective studies to disentangle the role of sIGF-1 in growth and health. This trial was registered at https://www.isrctn.com as ISRCTN42569496.",
keywords = "Faculty of Science, Moderate acute malnutrition, Insulin-like growth factor 1 (IGF-1), Low-income country, Body composition, Inflammation",
author = "Kj{\ae}r, {Thora Wesenberg} and Benedikte Grenov and Yam{\'e}ogo, {Charles W} and Christian Fabiansen and Ann-Sophie Iuel-Brockdorff and Bernardette Cichon and Nielsen, {Nick Schou} and Suzanne Filteau and Andr{\'e} Briend and Wells, {Jonathan C K} and Michaelsen, {Kim F.} and Henrik Friis and Daniel Faurholt-Jepsen and Christensen, {Vibeke Brix}",
note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.",
year = "2021",
month = may,
day = "8",
doi = "10.1093/ajcn/nqab120",
language = "English",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",

}

RIS

TY - JOUR

T1 - Correlates of serum IGF-1 in young children with moderate acute malnutrition: a cross-sectional study in Burkina Faso

AU - Kjær, Thora Wesenberg

AU - Grenov, Benedikte

AU - Yaméogo, Charles W

AU - Fabiansen, Christian

AU - Iuel-Brockdorff, Ann-Sophie

AU - Cichon, Bernardette

AU - Nielsen, Nick Schou

AU - Filteau, Suzanne

AU - Briend, André

AU - Wells, Jonathan C K

AU - Michaelsen, Kim F.

AU - Friis, Henrik

AU - Faurholt-Jepsen, Daniel

AU - Christensen, Vibeke Brix

N1 - © The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.

PY - 2021/5/8

Y1 - 2021/5/8

N2 - Background: Serum insulin-like growth factor 1 (sIGF-1) is an important growth factor in childhood. However, studies on sIGF-1 among children from low-income countries are few, and the role of body composition is unknown.Objectives: To assess the associations of anthropometry, body composition, inflammation, and breastfeeding with sIGF-1 among children with moderate acute malnutrition (MAM).Methods: A cross-sectional study based on admission data from 6- to 23-mo-old children with MAM participating in a nutrition intervention trial (Treatfood) in Burkina Faso. Linear regression analysis was used to identify correlates of sIGF-1.Results: Among 1546 children, the median (IQR) sIGF-1 was 12 (8.2-18.3) ng/mL. sIGF-1 was highest at 6 mo, with a nadir ∼10-11 mo, and higher in girls than boys. Length-for-age z score (LAZ), weight-for-length z score (WLZ), and midupper arm circumference were positively associated with sIGF-1 (P ≤ 0.001). Fat-free mass (FFM) was also positively associated, as sIGF-1 increased 1.5 (95% CI: 0.5, 2.5) ng/mL for each 1-kg increase in FFM. However, the association disappeared after adjustment for height. Elevated serum C-reactive protein and α1-acid glycoprotein were negatively associated with sIGF-1 (P ≤ 0.001), as was fever (P < 0.001) but not a positive malaria test per se (P = 0.15). Children never breastfed had lower sIGF-1 (-5.1; 95% CI: -9.8, -0.3).Conclusions: LAZ and WLZ were positively and inflammation negatively associated with sIGF-1. As all children were moderately malnourished and many had inflammation, this probably explains the very low median sIGF-1. The association of FFM with sIGF-1 was fully explained by height. There was a marked age pattern, with a nadir in late infancy, confirming findings from smaller studies from well-nourished populations. There is a need for prospective studies to disentangle the role of sIGF-1 in growth and health. This trial was registered at https://www.isrctn.com as ISRCTN42569496.

AB - Background: Serum insulin-like growth factor 1 (sIGF-1) is an important growth factor in childhood. However, studies on sIGF-1 among children from low-income countries are few, and the role of body composition is unknown.Objectives: To assess the associations of anthropometry, body composition, inflammation, and breastfeeding with sIGF-1 among children with moderate acute malnutrition (MAM).Methods: A cross-sectional study based on admission data from 6- to 23-mo-old children with MAM participating in a nutrition intervention trial (Treatfood) in Burkina Faso. Linear regression analysis was used to identify correlates of sIGF-1.Results: Among 1546 children, the median (IQR) sIGF-1 was 12 (8.2-18.3) ng/mL. sIGF-1 was highest at 6 mo, with a nadir ∼10-11 mo, and higher in girls than boys. Length-for-age z score (LAZ), weight-for-length z score (WLZ), and midupper arm circumference were positively associated with sIGF-1 (P ≤ 0.001). Fat-free mass (FFM) was also positively associated, as sIGF-1 increased 1.5 (95% CI: 0.5, 2.5) ng/mL for each 1-kg increase in FFM. However, the association disappeared after adjustment for height. Elevated serum C-reactive protein and α1-acid glycoprotein were negatively associated with sIGF-1 (P ≤ 0.001), as was fever (P < 0.001) but not a positive malaria test per se (P = 0.15). Children never breastfed had lower sIGF-1 (-5.1; 95% CI: -9.8, -0.3).Conclusions: LAZ and WLZ were positively and inflammation negatively associated with sIGF-1. As all children were moderately malnourished and many had inflammation, this probably explains the very low median sIGF-1. The association of FFM with sIGF-1 was fully explained by height. There was a marked age pattern, with a nadir in late infancy, confirming findings from smaller studies from well-nourished populations. There is a need for prospective studies to disentangle the role of sIGF-1 in growth and health. This trial was registered at https://www.isrctn.com as ISRCTN42569496.

KW - Faculty of Science

KW - Moderate acute malnutrition

KW - Insulin-like growth factor 1 (IGF-1)

KW - Low-income country

KW - Body composition

KW - Inflammation

U2 - 10.1093/ajcn/nqab120

DO - 10.1093/ajcn/nqab120

M3 - Journal article

C2 - 33963730

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

ER -

ID: 261450727