Correlation between asparaginase enzyme activity levels and coagulation parameters during childhood acute lymphoblastic leukemia treatment
Research output: Contribution to journal › Journal article › Research › peer-review
Thromboembolism is a serious toxicity in the treatment of acute lymphoblastic leukemia (ALL), but little is known about the correlation between asparaginase enzyme activity (ASA) levels and coagulation parameters. We included 65 non-high risk ALL patients, aged 1-17 years. Coagulation parameters and corresponding ASA levels were measured during asparaginase treatment. We found ASA to be negatively correlated with antithrombin and fibrinogen up to ASA levels of 250 IU/L, after which these parameters reached a plateau and did not decrease further with further increase of ASA. Patients with silent inactivation of asparaginase had normal coagulation parameters.
Original language | English |
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Article number | e30085 |
Book series | Medical and Pediatric Oncology. Supplement |
Volume | 70 |
Issue number | 2 |
Number of pages | 5 |
ISSN | 1545-5009 |
DOIs | |
Publication status | Published - 2023 |
- antithrombin, pediatric acute lymphoblastic leukemia, PEG-asparaginase, thromboembolism, toxicities, CHILDREN, RISK, THROMBOSIS, COAGULOPATHY
Research areas
ID: 327278800