Dental fluorosis developed in post-secretory enamel

Research output: Contribution to journalJournal articlepeer-review

The aim of this study was to test whether dental fluorosis can be produced by administration of chronic doses of fluoride during only the post-secretory stage of enamel mineralization. Eight control and eight experimental pigs matched by weight and litter were fed a low-fluoride diet (less than 0.05 mg F-/kg b.w. daily) from weaning to slaughter at 14 months. The test group received an oral dose of 2 mg F-/kg b.w. per day from 8 months of age. Lower fourth pre-molars were at the post-secretory stage at the start of fluoride administration (confirmed by tetracycline marker) and were just erupting at slaughter. All of the fourth pre-molar teeth from the test group developed diffuse enamel hypomineralization indistinguishable from human fluorosis. No such lesions were seen in any of the teeth from the control animals. It was concluded that enamel fluorosis may be caused by fluoride exposure in the maturation phase only. The pathogenic mechanism may be an effect either on the selective loss of protein or on the influx of mineral, both of which occur during the post-secretory or maturation stage of enamel formation.

Original languageEnglish
JournalJournal of Dental Research
Issue number12
Pages (from-to)1406-9
Number of pages4
Publication statusPublished - Dec 1986

    Research areas

  • Amelogenesis/drug effects, Animals, Dental Enamel/drug effects, Female, Fluorides/adverse effects, Fluorosis, Dental/etiology, Swine, Tooth Calcification/drug effects

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