Dermal uptake and percutaneous penetration of ten flame retardants in a human skin ex vivo model

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Dermal uptake and percutaneous penetration of ten flame retardants in a human skin ex vivo model. / Frederiksen, Marie; Vorkamp, Katrin; Jensen, Niels Martin; Sorensen, Jens Ahm; Knudsen, Lisbeth E.; Sørensen, Lars S.; Webster, Thomas F.; Nielsen, Jesper B.

In: Chemosphere, Vol. 162, 11.2016, p. 308-314.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Frederiksen, M, Vorkamp, K, Jensen, NM, Sorensen, JA, Knudsen, LE, Sørensen, LS, Webster, TF & Nielsen, JB 2016, 'Dermal uptake and percutaneous penetration of ten flame retardants in a human skin ex vivo model', Chemosphere, vol. 162, pp. 308-314. https://doi.org/10.1016/j.chemosphere.2016.07.100

APA

Frederiksen, M., Vorkamp, K., Jensen, N. M., Sorensen, J. A., Knudsen, L. E., Sørensen, L. S., Webster, T. F., & Nielsen, J. B. (2016). Dermal uptake and percutaneous penetration of ten flame retardants in a human skin ex vivo model. Chemosphere, 162, 308-314. https://doi.org/10.1016/j.chemosphere.2016.07.100

Vancouver

Frederiksen M, Vorkamp K, Jensen NM, Sorensen JA, Knudsen LE, Sørensen LS et al. Dermal uptake and percutaneous penetration of ten flame retardants in a human skin ex vivo model. Chemosphere. 2016 Nov;162:308-314. https://doi.org/10.1016/j.chemosphere.2016.07.100

Author

Frederiksen, Marie ; Vorkamp, Katrin ; Jensen, Niels Martin ; Sorensen, Jens Ahm ; Knudsen, Lisbeth E. ; Sørensen, Lars S. ; Webster, Thomas F. ; Nielsen, Jesper B. / Dermal uptake and percutaneous penetration of ten flame retardants in a human skin ex vivo model. In: Chemosphere. 2016 ; Vol. 162. pp. 308-314.

Bibtex

@article{1ae071f656c24f49a38ec9db065008d8,
title = "Dermal uptake and percutaneous penetration of ten flame retardants in a human skin ex vivo model",
abstract = "The dermal uptake and percutaneous penetration of ten organic flame retardants was measured using an ex vivo human skin model. The studied compounds were DBDPE, BTBPE, TBP-DBPE, EH-TBB, BEH-TEBP, α, β and γ-HBCDD as well as syn- and anti-DDC-CO. Little or none of the applied flame retardants was recovered in either type of the receptor fluids used (physiological and worst-case). However, significant fractions were recovered in the skin depot, particularly in the upper skin layers. The primary effect of the worst-case receptor fluid was deeper penetration into the skin. The recovered mass was used to calculate lower- and upper-bound permeability coefficients kp. Despite large structural variation between the studied compounds, a clear, significant decreasing trend of kp was observed with increasing log Kow. The results indicate that the dermis may provide a significant barrier for these highly lipophilic compounds. However, based on our results, dermal uptake should be considered in exposure assessments, though it may proceed in a time-lagged manner compared to less hydrophobic compounds.",
keywords = "NBFR, Brominated flame retardants, HBCDD, Skin deposition, Dermal exposure, Dechlorane plus",
author = "Marie Frederiksen and Katrin Vorkamp and Jensen, {Niels Martin} and Sorensen, {Jens Ahm} and Knudsen, {Lisbeth E.} and S{\o}rensen, {Lars S.} and Webster, {Thomas F.} and Nielsen, {Jesper B.}",
year = "2016",
month = nov,
doi = "10.1016/j.chemosphere.2016.07.100",
language = "English",
volume = "162",
pages = "308--314",
journal = "Chemosphere",
issn = "0045-6535",
publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Dermal uptake and percutaneous penetration of ten flame retardants in a human skin ex vivo model

AU - Frederiksen, Marie

AU - Vorkamp, Katrin

AU - Jensen, Niels Martin

AU - Sorensen, Jens Ahm

AU - Knudsen, Lisbeth E.

AU - Sørensen, Lars S.

AU - Webster, Thomas F.

AU - Nielsen, Jesper B.

PY - 2016/11

Y1 - 2016/11

N2 - The dermal uptake and percutaneous penetration of ten organic flame retardants was measured using an ex vivo human skin model. The studied compounds were DBDPE, BTBPE, TBP-DBPE, EH-TBB, BEH-TEBP, α, β and γ-HBCDD as well as syn- and anti-DDC-CO. Little or none of the applied flame retardants was recovered in either type of the receptor fluids used (physiological and worst-case). However, significant fractions were recovered in the skin depot, particularly in the upper skin layers. The primary effect of the worst-case receptor fluid was deeper penetration into the skin. The recovered mass was used to calculate lower- and upper-bound permeability coefficients kp. Despite large structural variation between the studied compounds, a clear, significant decreasing trend of kp was observed with increasing log Kow. The results indicate that the dermis may provide a significant barrier for these highly lipophilic compounds. However, based on our results, dermal uptake should be considered in exposure assessments, though it may proceed in a time-lagged manner compared to less hydrophobic compounds.

AB - The dermal uptake and percutaneous penetration of ten organic flame retardants was measured using an ex vivo human skin model. The studied compounds were DBDPE, BTBPE, TBP-DBPE, EH-TBB, BEH-TEBP, α, β and γ-HBCDD as well as syn- and anti-DDC-CO. Little or none of the applied flame retardants was recovered in either type of the receptor fluids used (physiological and worst-case). However, significant fractions were recovered in the skin depot, particularly in the upper skin layers. The primary effect of the worst-case receptor fluid was deeper penetration into the skin. The recovered mass was used to calculate lower- and upper-bound permeability coefficients kp. Despite large structural variation between the studied compounds, a clear, significant decreasing trend of kp was observed with increasing log Kow. The results indicate that the dermis may provide a significant barrier for these highly lipophilic compounds. However, based on our results, dermal uptake should be considered in exposure assessments, though it may proceed in a time-lagged manner compared to less hydrophobic compounds.

KW - NBFR

KW - Brominated flame retardants

KW - HBCDD

KW - Skin deposition

KW - Dermal exposure

KW - Dechlorane plus

U2 - 10.1016/j.chemosphere.2016.07.100

DO - 10.1016/j.chemosphere.2016.07.100

M3 - Journal article

C2 - 27513551

VL - 162

SP - 308

EP - 314

JO - Chemosphere

JF - Chemosphere

SN - 0045-6535

ER -

ID: 166939959