Design, synthesis, and in vitro pharmacology of new radiolabeled ¿-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity ¿-hydroxybutyric acid binding sites

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Design, synthesis, and in vitro pharmacology of new radiolabeled ¿-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity ¿-hydroxybutyric acid binding sites. / Sabbatini, Paola; Wellendorph, Petrine; Høg, Signe; Pedersen, Martin Holst Friborg; Bräuner-Osborne, Hans; Martiny, Lars; Frølund, Bente Flensborg; Clausen, Rasmus Prætorius.

In: Journal of Medicinal Chemistry, Vol. 53, No. 17, 2010, p. 6506-6510.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Sabbatini, P, Wellendorph, P, Høg, S, Pedersen, MHF, Bräuner-Osborne, H, Martiny, L, Frølund, BF & Clausen, RP 2010, 'Design, synthesis, and in vitro pharmacology of new radiolabeled ¿-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity ¿-hydroxybutyric acid binding sites', Journal of Medicinal Chemistry, vol. 53, no. 17, pp. 6506-6510. https://doi.org/10.1021/jm1006325

APA

Sabbatini, P., Wellendorph, P., Høg, S., Pedersen, M. H. F., Bräuner-Osborne, H., Martiny, L., ... Clausen, R. P. (2010). Design, synthesis, and in vitro pharmacology of new radiolabeled ¿-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity ¿-hydroxybutyric acid binding sites. Journal of Medicinal Chemistry, 53(17), 6506-6510. https://doi.org/10.1021/jm1006325

Vancouver

Sabbatini P, Wellendorph P, Høg S, Pedersen MHF, Bräuner-Osborne H, Martiny L et al. Design, synthesis, and in vitro pharmacology of new radiolabeled ¿-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity ¿-hydroxybutyric acid binding sites. Journal of Medicinal Chemistry. 2010;53(17):6506-6510. https://doi.org/10.1021/jm1006325

Author

Sabbatini, Paola ; Wellendorph, Petrine ; Høg, Signe ; Pedersen, Martin Holst Friborg ; Bräuner-Osborne, Hans ; Martiny, Lars ; Frølund, Bente Flensborg ; Clausen, Rasmus Prætorius. / Design, synthesis, and in vitro pharmacology of new radiolabeled ¿-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity ¿-hydroxybutyric acid binding sites. In: Journal of Medicinal Chemistry. 2010 ; Vol. 53, No. 17. pp. 6506-6510.

Bibtex

@article{66fd0990b75011df825b000ea68e967b,
title = "Design, synthesis, and in vitro pharmacology of new radiolabeled ¿-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity ¿-hydroxybutyric acid binding sites",
abstract = "gamma-Hydroxybutyric acid (GHB) is a psychotropic compound endogenous to the brain. Despite its potential physiological significance, the complete molecular mechanisms of action remain unexplained. To facilitate the isolation and identification of the high-affinity GHB binding site, we herein report the design and synthesis of the first (125)I-labeled radioligands in the field, one of which contains a photoaffinity label which enables it to bind irreversibly to the high-affinity GHB binding sites.",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "Paola Sabbatini and Petrine Wellendorph and Signe H{\o}g and Pedersen, {Martin Holst Friborg} and Hans Br{\"a}uner-Osborne and Lars Martiny and Fr{\o}lund, {Bente Flensborg} and Clausen, {Rasmus Pr{\ae}torius}",
year = "2010",
doi = "10.1021/jm1006325",
language = "English",
volume = "53",
pages = "6506--6510",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
number = "17",

}

RIS

TY - JOUR

T1 - Design, synthesis, and in vitro pharmacology of new radiolabeled ¿-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity ¿-hydroxybutyric acid binding sites

AU - Sabbatini, Paola

AU - Wellendorph, Petrine

AU - Høg, Signe

AU - Pedersen, Martin Holst Friborg

AU - Bräuner-Osborne, Hans

AU - Martiny, Lars

AU - Frølund, Bente Flensborg

AU - Clausen, Rasmus Prætorius

PY - 2010

Y1 - 2010

N2 - gamma-Hydroxybutyric acid (GHB) is a psychotropic compound endogenous to the brain. Despite its potential physiological significance, the complete molecular mechanisms of action remain unexplained. To facilitate the isolation and identification of the high-affinity GHB binding site, we herein report the design and synthesis of the first (125)I-labeled radioligands in the field, one of which contains a photoaffinity label which enables it to bind irreversibly to the high-affinity GHB binding sites.

AB - gamma-Hydroxybutyric acid (GHB) is a psychotropic compound endogenous to the brain. Despite its potential physiological significance, the complete molecular mechanisms of action remain unexplained. To facilitate the isolation and identification of the high-affinity GHB binding site, we herein report the design and synthesis of the first (125)I-labeled radioligands in the field, one of which contains a photoaffinity label which enables it to bind irreversibly to the high-affinity GHB binding sites.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1021/jm1006325

DO - 10.1021/jm1006325

M3 - Journal article

C2 - 20715819

VL - 53

SP - 6506

EP - 6510

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

SN - 0022-2623

IS - 17

ER -

ID: 21772547