Diabetes & Women's Health (DWH) Study: An observational study of long-term health consequences of gestational diabetes, their determinants and underlying mechanisms in the USA and Denmark

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Diabetes & Women's Health (DWH) Study : An observational study of long-term health consequences of gestational diabetes, their determinants and underlying mechanisms in the USA and Denmark. / Zhang, Cuilin; Olsen, Sjurdur F.; Hinkle, Stefanie N.; Gore-Langton, Robert E.; Vaag, Allan; Grunnet, Louise Groth; Yeung, Edwina H.; Bao, Wei; Bowers, Katherine; Liu, Aiyi; Mills, James L.; Sherman, Seth; Gaskins, Audrey J.; Ley, Sylvia H.; Madsen, Camilla M.; Chavarro, Jorge E.; Hu, Frank B.

In: BMJ Open, Vol. 9, No. 4, e025517, 2019.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Zhang, C, Olsen, SF, Hinkle, SN, Gore-Langton, RE, Vaag, A, Grunnet, LG, Yeung, EH, Bao, W, Bowers, K, Liu, A, Mills, JL, Sherman, S, Gaskins, AJ, Ley, SH, Madsen, CM, Chavarro, JE & Hu, FB 2019, 'Diabetes & Women's Health (DWH) Study: An observational study of long-term health consequences of gestational diabetes, their determinants and underlying mechanisms in the USA and Denmark', BMJ Open, vol. 9, no. 4, e025517. https://doi.org/10.1136/bmjopen-2018-025517

APA

Zhang, C., Olsen, S. F., Hinkle, S. N., Gore-Langton, R. E., Vaag, A., Grunnet, L. G., Yeung, E. H., Bao, W., Bowers, K., Liu, A., Mills, J. L., Sherman, S., Gaskins, A. J., Ley, S. H., Madsen, C. M., Chavarro, J. E., & Hu, F. B. (2019). Diabetes & Women's Health (DWH) Study: An observational study of long-term health consequences of gestational diabetes, their determinants and underlying mechanisms in the USA and Denmark. BMJ Open, 9(4), [e025517]. https://doi.org/10.1136/bmjopen-2018-025517

Vancouver

Zhang C, Olsen SF, Hinkle SN, Gore-Langton RE, Vaag A, Grunnet LG et al. Diabetes & Women's Health (DWH) Study: An observational study of long-term health consequences of gestational diabetes, their determinants and underlying mechanisms in the USA and Denmark. BMJ Open. 2019;9(4). e025517. https://doi.org/10.1136/bmjopen-2018-025517

Author

Zhang, Cuilin ; Olsen, Sjurdur F. ; Hinkle, Stefanie N. ; Gore-Langton, Robert E. ; Vaag, Allan ; Grunnet, Louise Groth ; Yeung, Edwina H. ; Bao, Wei ; Bowers, Katherine ; Liu, Aiyi ; Mills, James L. ; Sherman, Seth ; Gaskins, Audrey J. ; Ley, Sylvia H. ; Madsen, Camilla M. ; Chavarro, Jorge E. ; Hu, Frank B. / Diabetes & Women's Health (DWH) Study : An observational study of long-term health consequences of gestational diabetes, their determinants and underlying mechanisms in the USA and Denmark. In: BMJ Open. 2019 ; Vol. 9, No. 4.

Bibtex

@article{8f7d26503c914f8db93e770a04553553,
title = "Diabetes & Women's Health (DWH) Study: An observational study of long-term health consequences of gestational diabetes, their determinants and underlying mechanisms in the USA and Denmark",
abstract = "Purpose Women who experience gestational diabetes mellitus (GDM) are at exceptionally high-risk of developing type 2 diabetes (T2DM) later in life. However, limited information is available about genetic and environmental factors that are implicated in the progression from GDM to T2DM. Participants The Diabetes & Women's Health (DWH) Study applied a hybrid design, which combined new prospective data collection with existing data in two prospective cohorts, the Danish National Birth Cohort (DNBC) and the Nurses' Health Study II (NHS II). In total, the DWH Study identified 7759 women with a GDM diagnosis from both cohorts; 4457 women participated in the DWH Study data collection, which included two cycles of follow-up from 2012 to 2014 and 2014 to 2016. Findings to date Progression from GDM to T2DM was high. In the NHS II group, by 2013, 23.1% (n=846/3667) developed T2DM. In the DNBC group, at cycle 1 (2012-2014), the progression rate was even higher: 27.2% (n=215/790) had developed T2DM. Furthermore, we have shown that women who had GDM experienced a significantly greater risk of hypertension and cardiovascular diseases, as well as early stages of glomerular hyperfiltration and renal damage. Moreover, the DWH Study findings have shown that healthful diet and lifestyle factors and weight control were related to a lower risk of T2DM, hypertension and cardiovascular diseases. Future plans Primary data collection for the DWH Study is complete and investigators are currently investigating interactions of the abovementioned modifiable factors with T2DM genetic susceptibility in determining the risk of progression from GDM to T2DM. Findings from ongoing work will provide further insights for identifying more precise prevention strategies for T2DM and comorbidities in this high-risk population. Future work will examine novel biomarkers of health and disease in this cohort.",
keywords = "diabetes in pregnancy, epidemiology, gestational diabetes, public health",
author = "Cuilin Zhang and Olsen, {Sjurdur F.} and Hinkle, {Stefanie N.} and Gore-Langton, {Robert E.} and Allan Vaag and Grunnet, {Louise Groth} and Yeung, {Edwina H.} and Wei Bao and Katherine Bowers and Aiyi Liu and Mills, {James L.} and Seth Sherman and Gaskins, {Audrey J.} and Ley, {Sylvia H.} and Madsen, {Camilla M.} and Chavarro, {Jorge E.} and Hu, {Frank B.}",
note = "Publisher Copyright: {\textcopyright} Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2019",
doi = "10.1136/bmjopen-2018-025517",
language = "English",
volume = "9",
journal = "BMJ Open",
issn = "2044-6055",
publisher = "BMJ Publishing Group",
number = "4",

}

RIS

TY - JOUR

T1 - Diabetes & Women's Health (DWH) Study

T2 - An observational study of long-term health consequences of gestational diabetes, their determinants and underlying mechanisms in the USA and Denmark

AU - Zhang, Cuilin

AU - Olsen, Sjurdur F.

AU - Hinkle, Stefanie N.

AU - Gore-Langton, Robert E.

AU - Vaag, Allan

AU - Grunnet, Louise Groth

AU - Yeung, Edwina H.

AU - Bao, Wei

AU - Bowers, Katherine

AU - Liu, Aiyi

AU - Mills, James L.

AU - Sherman, Seth

AU - Gaskins, Audrey J.

AU - Ley, Sylvia H.

AU - Madsen, Camilla M.

AU - Chavarro, Jorge E.

AU - Hu, Frank B.

N1 - Publisher Copyright: © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2019

Y1 - 2019

N2 - Purpose Women who experience gestational diabetes mellitus (GDM) are at exceptionally high-risk of developing type 2 diabetes (T2DM) later in life. However, limited information is available about genetic and environmental factors that are implicated in the progression from GDM to T2DM. Participants The Diabetes & Women's Health (DWH) Study applied a hybrid design, which combined new prospective data collection with existing data in two prospective cohorts, the Danish National Birth Cohort (DNBC) and the Nurses' Health Study II (NHS II). In total, the DWH Study identified 7759 women with a GDM diagnosis from both cohorts; 4457 women participated in the DWH Study data collection, which included two cycles of follow-up from 2012 to 2014 and 2014 to 2016. Findings to date Progression from GDM to T2DM was high. In the NHS II group, by 2013, 23.1% (n=846/3667) developed T2DM. In the DNBC group, at cycle 1 (2012-2014), the progression rate was even higher: 27.2% (n=215/790) had developed T2DM. Furthermore, we have shown that women who had GDM experienced a significantly greater risk of hypertension and cardiovascular diseases, as well as early stages of glomerular hyperfiltration and renal damage. Moreover, the DWH Study findings have shown that healthful diet and lifestyle factors and weight control were related to a lower risk of T2DM, hypertension and cardiovascular diseases. Future plans Primary data collection for the DWH Study is complete and investigators are currently investigating interactions of the abovementioned modifiable factors with T2DM genetic susceptibility in determining the risk of progression from GDM to T2DM. Findings from ongoing work will provide further insights for identifying more precise prevention strategies for T2DM and comorbidities in this high-risk population. Future work will examine novel biomarkers of health and disease in this cohort.

AB - Purpose Women who experience gestational diabetes mellitus (GDM) are at exceptionally high-risk of developing type 2 diabetes (T2DM) later in life. However, limited information is available about genetic and environmental factors that are implicated in the progression from GDM to T2DM. Participants The Diabetes & Women's Health (DWH) Study applied a hybrid design, which combined new prospective data collection with existing data in two prospective cohorts, the Danish National Birth Cohort (DNBC) and the Nurses' Health Study II (NHS II). In total, the DWH Study identified 7759 women with a GDM diagnosis from both cohorts; 4457 women participated in the DWH Study data collection, which included two cycles of follow-up from 2012 to 2014 and 2014 to 2016. Findings to date Progression from GDM to T2DM was high. In the NHS II group, by 2013, 23.1% (n=846/3667) developed T2DM. In the DNBC group, at cycle 1 (2012-2014), the progression rate was even higher: 27.2% (n=215/790) had developed T2DM. Furthermore, we have shown that women who had GDM experienced a significantly greater risk of hypertension and cardiovascular diseases, as well as early stages of glomerular hyperfiltration and renal damage. Moreover, the DWH Study findings have shown that healthful diet and lifestyle factors and weight control were related to a lower risk of T2DM, hypertension and cardiovascular diseases. Future plans Primary data collection for the DWH Study is complete and investigators are currently investigating interactions of the abovementioned modifiable factors with T2DM genetic susceptibility in determining the risk of progression from GDM to T2DM. Findings from ongoing work will provide further insights for identifying more precise prevention strategies for T2DM and comorbidities in this high-risk population. Future work will examine novel biomarkers of health and disease in this cohort.

KW - diabetes in pregnancy

KW - epidemiology

KW - gestational diabetes

KW - public health

U2 - 10.1136/bmjopen-2018-025517

DO - 10.1136/bmjopen-2018-025517

M3 - Journal article

C2 - 31048434

AN - SCOPUS:85065464504

VL - 9

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

IS - 4

M1 - e025517

ER -

ID: 286503676