Diabetes, diabetes treatment, and mammographic density in Danish Diet, Cancer, and Health cohort

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Diabetes, diabetes treatment, and mammographic density in Danish Diet, Cancer, and Health cohort. / Buschard, Karsten; Thomassen, Katrin; Lynge, Elsebeth; Vejborg, Ilse; Tjønneland, Anne; von Euler-Chelpin, My; Andersen, Zorana Jovanovic.

In: Cancer Causes & Control, Vol. 28, No. 1, 01.2017, p. 13–21.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Buschard, K, Thomassen, K, Lynge, E, Vejborg, I, Tjønneland, A, von Euler-Chelpin, M & Andersen, ZJ 2017, 'Diabetes, diabetes treatment, and mammographic density in Danish Diet, Cancer, and Health cohort', Cancer Causes & Control, vol. 28, no. 1, pp. 13–21. https://doi.org/10.1007/s10552-016-0829-z

APA

Buschard, K., Thomassen, K., Lynge, E., Vejborg, I., Tjønneland, A., von Euler-Chelpin, M., & Andersen, Z. J. (2017). Diabetes, diabetes treatment, and mammographic density in Danish Diet, Cancer, and Health cohort. Cancer Causes & Control, 28(1), 13–21. https://doi.org/10.1007/s10552-016-0829-z

Vancouver

Buschard K, Thomassen K, Lynge E, Vejborg I, Tjønneland A, von Euler-Chelpin M et al. Diabetes, diabetes treatment, and mammographic density in Danish Diet, Cancer, and Health cohort. Cancer Causes & Control. 2017 Jan;28(1):13–21. https://doi.org/10.1007/s10552-016-0829-z

Author

Buschard, Karsten ; Thomassen, Katrin ; Lynge, Elsebeth ; Vejborg, Ilse ; Tjønneland, Anne ; von Euler-Chelpin, My ; Andersen, Zorana Jovanovic. / Diabetes, diabetes treatment, and mammographic density in Danish Diet, Cancer, and Health cohort. In: Cancer Causes & Control. 2017 ; Vol. 28, No. 1. pp. 13–21.

Bibtex

@article{1b75a4de11e2447eb9453999570ce250,
title = "Diabetes, diabetes treatment, and mammographic density in Danish Diet, Cancer, and Health cohort",
abstract = "PURPOSE: We examined whether diabetes and diabetes treatment are associated with MD in a cohort study of Danish women above age of 50 years.METHODS: Study cohort consisted of 5,644 women (4,500 postmenopausal) who participated in the Danish Diet, Cancer, and Health cohort (1993-1997) and subsequently attended mammographic screening in Copenhagen (1993-2001). We used MD assessed at the first screening after the cohort entry, defined as mixed/dense or fatty. Diabetes diagnoses and diabetes treatments (diet, insulin, or oral antidiabetic agents) were self-reported at the time of recruitment (1993-1997). The association between MD and diabetes was analyzed by logistic regression adjusted for potential confounders. Effect modification by menopausal status and body mass index (BMI) was performed by introducing an interaction term into the model and tested by Wald test.RESULTS: Of 5,644 women with mean age of 56 years, 137 (2.4{\%}) had diabetes and 3,180 (56.3{\%}) had mixed/dense breasts. Having diabetes was significantly inversely associated with having mixed/dense breasts, in both, the crude model (odds ratio; 95{\%} confidence interval: 0.33; 0.23-0.48), and after adjustment for adiposity and other risk factors (0.61; 0.40-0.92). Similar inverse associations were observed for 44 women who controlled diabetes by diet only and did not receive any medication (0.56; 0.27-1.14), and 62 who took oral antidiabetic agents only for diabetes (0.59; 0.32-1.09), while women taking insulin had increased odds of mixed/dense breasts (2.08; 0.68-6.35). There was no effect modification of these associations by menopausal status or BMI.CONCLUSIONS: Having diabetes controlled by diet or oral antidiabetic agents is associated with a decrease in MD, whereas taking insulin is associated with an increase in MD.",
author = "Karsten Buschard and Katrin Thomassen and Elsebeth Lynge and Ilse Vejborg and Anne Tj{\o}nneland and {von Euler-Chelpin}, My and Andersen, {Zorana Jovanovic}",
year = "2017",
month = "1",
doi = "10.1007/s10552-016-0829-z",
language = "English",
volume = "28",
pages = "13–21",
journal = "Cancer Causes & Control",
issn = "0957-5243",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Diabetes, diabetes treatment, and mammographic density in Danish Diet, Cancer, and Health cohort

AU - Buschard, Karsten

AU - Thomassen, Katrin

AU - Lynge, Elsebeth

AU - Vejborg, Ilse

AU - Tjønneland, Anne

AU - von Euler-Chelpin, My

AU - Andersen, Zorana Jovanovic

PY - 2017/1

Y1 - 2017/1

N2 - PURPOSE: We examined whether diabetes and diabetes treatment are associated with MD in a cohort study of Danish women above age of 50 years.METHODS: Study cohort consisted of 5,644 women (4,500 postmenopausal) who participated in the Danish Diet, Cancer, and Health cohort (1993-1997) and subsequently attended mammographic screening in Copenhagen (1993-2001). We used MD assessed at the first screening after the cohort entry, defined as mixed/dense or fatty. Diabetes diagnoses and diabetes treatments (diet, insulin, or oral antidiabetic agents) were self-reported at the time of recruitment (1993-1997). The association between MD and diabetes was analyzed by logistic regression adjusted for potential confounders. Effect modification by menopausal status and body mass index (BMI) was performed by introducing an interaction term into the model and tested by Wald test.RESULTS: Of 5,644 women with mean age of 56 years, 137 (2.4%) had diabetes and 3,180 (56.3%) had mixed/dense breasts. Having diabetes was significantly inversely associated with having mixed/dense breasts, in both, the crude model (odds ratio; 95% confidence interval: 0.33; 0.23-0.48), and after adjustment for adiposity and other risk factors (0.61; 0.40-0.92). Similar inverse associations were observed for 44 women who controlled diabetes by diet only and did not receive any medication (0.56; 0.27-1.14), and 62 who took oral antidiabetic agents only for diabetes (0.59; 0.32-1.09), while women taking insulin had increased odds of mixed/dense breasts (2.08; 0.68-6.35). There was no effect modification of these associations by menopausal status or BMI.CONCLUSIONS: Having diabetes controlled by diet or oral antidiabetic agents is associated with a decrease in MD, whereas taking insulin is associated with an increase in MD.

AB - PURPOSE: We examined whether diabetes and diabetes treatment are associated with MD in a cohort study of Danish women above age of 50 years.METHODS: Study cohort consisted of 5,644 women (4,500 postmenopausal) who participated in the Danish Diet, Cancer, and Health cohort (1993-1997) and subsequently attended mammographic screening in Copenhagen (1993-2001). We used MD assessed at the first screening after the cohort entry, defined as mixed/dense or fatty. Diabetes diagnoses and diabetes treatments (diet, insulin, or oral antidiabetic agents) were self-reported at the time of recruitment (1993-1997). The association between MD and diabetes was analyzed by logistic regression adjusted for potential confounders. Effect modification by menopausal status and body mass index (BMI) was performed by introducing an interaction term into the model and tested by Wald test.RESULTS: Of 5,644 women with mean age of 56 years, 137 (2.4%) had diabetes and 3,180 (56.3%) had mixed/dense breasts. Having diabetes was significantly inversely associated with having mixed/dense breasts, in both, the crude model (odds ratio; 95% confidence interval: 0.33; 0.23-0.48), and after adjustment for adiposity and other risk factors (0.61; 0.40-0.92). Similar inverse associations were observed for 44 women who controlled diabetes by diet only and did not receive any medication (0.56; 0.27-1.14), and 62 who took oral antidiabetic agents only for diabetes (0.59; 0.32-1.09), while women taking insulin had increased odds of mixed/dense breasts (2.08; 0.68-6.35). There was no effect modification of these associations by menopausal status or BMI.CONCLUSIONS: Having diabetes controlled by diet or oral antidiabetic agents is associated with a decrease in MD, whereas taking insulin is associated with an increase in MD.

U2 - 10.1007/s10552-016-0829-z

DO - 10.1007/s10552-016-0829-z

M3 - Journal article

VL - 28

SP - 13

EP - 21

JO - Cancer Causes & Control

JF - Cancer Causes & Control

SN - 0957-5243

IS - 1

ER -

ID: 169728937