Dietary ascorbic acid and subsequent change in body weight and waist circumference: associations may depend on genetic predisposition to obesity - a prospective study of three independent cohorts

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Dietary ascorbic acid and subsequent change in body weight and waist circumference : associations may depend on genetic predisposition to obesity - a prospective study of three independent cohorts. / Larsen, Sofus C; Angquist, Lars; Ahluwalia, Tarun Veer Singh; Skaaby, Tea; Roswall, Nina; Tjønneland, Anne; Halkjær, Jytte; Overvad, Kim; Pedersen, Oluf; Hansen, Torben; Linneberg, Allan; Husemoen, Lise Lotte N; Toft, Ulla; Heitmann, Berit L; Sørensen, Thorkild I A.

In: Nutrition Journal, Vol. 13, 43, 2014, p. 1-11.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Larsen, SC, Angquist, L, Ahluwalia, TVS, Skaaby, T, Roswall, N, Tjønneland, A, Halkjær, J, Overvad, K, Pedersen, O, Hansen, T, Linneberg, A, Husemoen, LLN, Toft, U, Heitmann, BL & Sørensen, TIA 2014, 'Dietary ascorbic acid and subsequent change in body weight and waist circumference: associations may depend on genetic predisposition to obesity - a prospective study of three independent cohorts', Nutrition Journal, vol. 13, 43, pp. 1-11. https://doi.org/10.1186/1475-2891-13-43

APA

Larsen, S. C., Angquist, L., Ahluwalia, T. V. S., Skaaby, T., Roswall, N., Tjønneland, A., ... Sørensen, T. I. A. (2014). Dietary ascorbic acid and subsequent change in body weight and waist circumference: associations may depend on genetic predisposition to obesity - a prospective study of three independent cohorts. Nutrition Journal, 13, 1-11. [43]. https://doi.org/10.1186/1475-2891-13-43

Vancouver

Larsen SC, Angquist L, Ahluwalia TVS, Skaaby T, Roswall N, Tjønneland A et al. Dietary ascorbic acid and subsequent change in body weight and waist circumference: associations may depend on genetic predisposition to obesity - a prospective study of three independent cohorts. Nutrition Journal. 2014;13:1-11. 43. https://doi.org/10.1186/1475-2891-13-43

Author

Larsen, Sofus C ; Angquist, Lars ; Ahluwalia, Tarun Veer Singh ; Skaaby, Tea ; Roswall, Nina ; Tjønneland, Anne ; Halkjær, Jytte ; Overvad, Kim ; Pedersen, Oluf ; Hansen, Torben ; Linneberg, Allan ; Husemoen, Lise Lotte N ; Toft, Ulla ; Heitmann, Berit L ; Sørensen, Thorkild I A. / Dietary ascorbic acid and subsequent change in body weight and waist circumference : associations may depend on genetic predisposition to obesity - a prospective study of three independent cohorts. In: Nutrition Journal. 2014 ; Vol. 13. pp. 1-11.

Bibtex

@article{65bcf04013694de397a219e505bf934a,
title = "Dietary ascorbic acid and subsequent change in body weight and waist circumference: associations may depend on genetic predisposition to obesity - a prospective study of three independent cohorts",
abstract = "BACKGROUND: Cross-sectional data suggests that a low level of plasma ascorbic acid positively associates with both Body Mass Index (BMI) and Waist Circumference (WC). This leads to questions about a possible relationship between dietary intake of ascorbic acid and subsequent changes in anthropometry, and whether such associations may depend on genetic predisposition to obesity. Hence, we examined whether dietary ascorbic acid, possibly in interaction with the genetic predisposition to a high BMI, WC or waist-hip ratio adjusted for BMI (WHR), associates with subsequent annual changes in weight (∆BW) and waist circumference (∆WC).METHODS: A total of 7,569 participants' from MONICA, the Diet Cancer and Health study and the INTER99 study were included in the study. We combined 50 obesity associated single nucleotide polymorphisms (SNPs) in four genetic scores: a score of all SNPs and a score for each of the traits (BMI, WC and WHR) with which the SNPs associate. Linear regression was used to examine the association between ascorbic acid intake and ΔBW or ΔWC. SNP-score × ascorbic acid interactions were examined by adding product terms to the models.RESULTS: We found no significant associations between dietary ascorbic acid and ∆BW or ∆WC. Regarding SNP-score × ascorbic acid interactions, each additional risk allele of the 14 WHR associated SNPs associated with a ∆WC of 0.039 cm/year (P = 0.02, 95{\%} CI: 0.005 to 0.073) per 100 mg/day higher ascorbic acid intake. However, the association to ∆WC only remained borderline significant after adjustment for ∆BW.CONCLUSION: In general, our study does not support an association between dietary ascorbic acid and ∆BW or ∆WC, but a diet with a high content of ascorbic acid may be weakly associated to higher WC gain among people who are genetically predisposed to a high WHR. However, given the quite limited association any public health relevance is questionable.",
keywords = "Ascorbic Acid, Body Mass Index, Body Weight, Cohort Studies, Denmark, Diet, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Obesity, Polymorphism, Single Nucleotide, Prospective Studies, Waist Circumference, Waist-Hip Ratio",
author = "Larsen, {Sofus C} and Lars Angquist and Ahluwalia, {Tarun Veer Singh} and Tea Skaaby and Nina Roswall and Anne Tj{\o}nneland and Jytte Halkj{\ae}r and Kim Overvad and Oluf Pedersen and Torben Hansen and Allan Linneberg and Husemoen, {Lise Lotte N} and Ulla Toft and Heitmann, {Berit L} and S{\o}rensen, {Thorkild I A}",
year = "2014",
doi = "10.1186/1475-2891-13-43",
language = "English",
volume = "13",
pages = "1--11",
journal = "Nutrition Journal",
issn = "1475-2891",
publisher = "BioMed Central",

}

RIS

TY - JOUR

T1 - Dietary ascorbic acid and subsequent change in body weight and waist circumference

T2 - associations may depend on genetic predisposition to obesity - a prospective study of three independent cohorts

AU - Larsen, Sofus C

AU - Angquist, Lars

AU - Ahluwalia, Tarun Veer Singh

AU - Skaaby, Tea

AU - Roswall, Nina

AU - Tjønneland, Anne

AU - Halkjær, Jytte

AU - Overvad, Kim

AU - Pedersen, Oluf

AU - Hansen, Torben

AU - Linneberg, Allan

AU - Husemoen, Lise Lotte N

AU - Toft, Ulla

AU - Heitmann, Berit L

AU - Sørensen, Thorkild I A

PY - 2014

Y1 - 2014

N2 - BACKGROUND: Cross-sectional data suggests that a low level of plasma ascorbic acid positively associates with both Body Mass Index (BMI) and Waist Circumference (WC). This leads to questions about a possible relationship between dietary intake of ascorbic acid and subsequent changes in anthropometry, and whether such associations may depend on genetic predisposition to obesity. Hence, we examined whether dietary ascorbic acid, possibly in interaction with the genetic predisposition to a high BMI, WC or waist-hip ratio adjusted for BMI (WHR), associates with subsequent annual changes in weight (∆BW) and waist circumference (∆WC).METHODS: A total of 7,569 participants' from MONICA, the Diet Cancer and Health study and the INTER99 study were included in the study. We combined 50 obesity associated single nucleotide polymorphisms (SNPs) in four genetic scores: a score of all SNPs and a score for each of the traits (BMI, WC and WHR) with which the SNPs associate. Linear regression was used to examine the association between ascorbic acid intake and ΔBW or ΔWC. SNP-score × ascorbic acid interactions were examined by adding product terms to the models.RESULTS: We found no significant associations between dietary ascorbic acid and ∆BW or ∆WC. Regarding SNP-score × ascorbic acid interactions, each additional risk allele of the 14 WHR associated SNPs associated with a ∆WC of 0.039 cm/year (P = 0.02, 95% CI: 0.005 to 0.073) per 100 mg/day higher ascorbic acid intake. However, the association to ∆WC only remained borderline significant after adjustment for ∆BW.CONCLUSION: In general, our study does not support an association between dietary ascorbic acid and ∆BW or ∆WC, but a diet with a high content of ascorbic acid may be weakly associated to higher WC gain among people who are genetically predisposed to a high WHR. However, given the quite limited association any public health relevance is questionable.

AB - BACKGROUND: Cross-sectional data suggests that a low level of plasma ascorbic acid positively associates with both Body Mass Index (BMI) and Waist Circumference (WC). This leads to questions about a possible relationship between dietary intake of ascorbic acid and subsequent changes in anthropometry, and whether such associations may depend on genetic predisposition to obesity. Hence, we examined whether dietary ascorbic acid, possibly in interaction with the genetic predisposition to a high BMI, WC or waist-hip ratio adjusted for BMI (WHR), associates with subsequent annual changes in weight (∆BW) and waist circumference (∆WC).METHODS: A total of 7,569 participants' from MONICA, the Diet Cancer and Health study and the INTER99 study were included in the study. We combined 50 obesity associated single nucleotide polymorphisms (SNPs) in four genetic scores: a score of all SNPs and a score for each of the traits (BMI, WC and WHR) with which the SNPs associate. Linear regression was used to examine the association between ascorbic acid intake and ΔBW or ΔWC. SNP-score × ascorbic acid interactions were examined by adding product terms to the models.RESULTS: We found no significant associations between dietary ascorbic acid and ∆BW or ∆WC. Regarding SNP-score × ascorbic acid interactions, each additional risk allele of the 14 WHR associated SNPs associated with a ∆WC of 0.039 cm/year (P = 0.02, 95% CI: 0.005 to 0.073) per 100 mg/day higher ascorbic acid intake. However, the association to ∆WC only remained borderline significant after adjustment for ∆BW.CONCLUSION: In general, our study does not support an association between dietary ascorbic acid and ∆BW or ∆WC, but a diet with a high content of ascorbic acid may be weakly associated to higher WC gain among people who are genetically predisposed to a high WHR. However, given the quite limited association any public health relevance is questionable.

KW - Ascorbic Acid

KW - Body Mass Index

KW - Body Weight

KW - Cohort Studies

KW - Denmark

KW - Diet

KW - Female

KW - Genetic Predisposition to Disease

KW - Humans

KW - Male

KW - Middle Aged

KW - Obesity

KW - Polymorphism, Single Nucleotide

KW - Prospective Studies

KW - Waist Circumference

KW - Waist-Hip Ratio

U2 - 10.1186/1475-2891-13-43

DO - 10.1186/1475-2891-13-43

M3 - Journal article

C2 - 24886192

VL - 13

SP - 1

EP - 11

JO - Nutrition Journal

JF - Nutrition Journal

SN - 1475-2891

M1 - 43

ER -

ID: 138312195