Differential nongenetic impact of birth weight versus third-trimester growth velocity on glucose metabolism and magnetic resonance imaging abdominal obesity in young healthy twins

Research output: Contribution to journalJournal articleResearchpeer-review

Kasper Pilgaard, Thomas Hammershaimb Mosbech, Louise Grunnet, Hans Eiberg, Gerrit Van Hall, Eva Fallentin, Torben Kjeldgaard Larsen, Rasmus Larsen, Pernille Poulsen, Allan Vaag

Low birth weight is associated with type 2 diabetes, which to some extent may be mediated via abdominal adiposity and insulin resistance. Fetal growth velocity is high during the third trimester, constituting a potential critical window for organ programming. Intra-pair differences among monozygotic twins are instrumental in determining nongenetic associations between early environment and adult metabolic phenotype.
Original languageEnglish
JournalJournal of Clinical Endocrinology and Metabolism
Volume96
Issue number9
Pages (from-to)2835-43
Number of pages9
ISSN0021-972X
DOIs
Publication statusPublished - 2011

    Research areas

  • Adolescent, Birth Weight, Body Composition, Female, Glucose, Glucose Clamp Technique, Humans, Infant, Low Birth Weight, Infant, Newborn, Insulin, Insulin Resistance, Male, Obesity, Abdominal, Sex Factors, Twins, Young Adult

ID: 38489510