Discrimination ability of comorbidity, frailty, and subjective health to predict mortality in community-dwelling older people: Population based prospective cohort study

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Discrimination ability of comorbidity, frailty, and subjective health to predict mortality in community-dwelling older people : Population based prospective cohort study. / Kusumastuti, Sasmita; Gerds, Thomas Alexander; Lund, Rikke; Mortensen, Erik Lykke; Westendorp, Rudi G. J.

In: European Journal of Internal Medicine, Vol. 42, 07.2017, p. 29-38.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Kusumastuti, S, Gerds, TA, Lund, R, Mortensen, EL & Westendorp, RGJ 2017, 'Discrimination ability of comorbidity, frailty, and subjective health to predict mortality in community-dwelling older people: Population based prospective cohort study', European Journal of Internal Medicine, vol. 42, pp. 29-38. https://doi.org/10.1016/j.ejim.2017.05.016

APA

Kusumastuti, S., Gerds, T. A., Lund, R., Mortensen, E. L., & Westendorp, R. G. J. (2017). Discrimination ability of comorbidity, frailty, and subjective health to predict mortality in community-dwelling older people: Population based prospective cohort study. European Journal of Internal Medicine, 42, 29-38. https://doi.org/10.1016/j.ejim.2017.05.016

Vancouver

Kusumastuti S, Gerds TA, Lund R, Mortensen EL, Westendorp RGJ. Discrimination ability of comorbidity, frailty, and subjective health to predict mortality in community-dwelling older people: Population based prospective cohort study. European Journal of Internal Medicine. 2017 Jul;42:29-38. https://doi.org/10.1016/j.ejim.2017.05.016

Author

Kusumastuti, Sasmita ; Gerds, Thomas Alexander ; Lund, Rikke ; Mortensen, Erik Lykke ; Westendorp, Rudi G. J. / Discrimination ability of comorbidity, frailty, and subjective health to predict mortality in community-dwelling older people : Population based prospective cohort study. In: European Journal of Internal Medicine. 2017 ; Vol. 42. pp. 29-38.

Bibtex

@article{55bfc1cbc7a74eeda571d41d1f5096e7,
title = "Discrimination ability of comorbidity, frailty, and subjective health to predict mortality in community-dwelling older people: Population based prospective cohort study",
abstract = "OBJECTIVE: To investigate the added value of comorbidity, frailty, and subjective health to mortality predictions in community-dwelling older people and whether it changes with increasing age.PARTICIPANTS: 36,751 community-dwelling subjects aged 50-100 from the longitudinal Survey of Health, Ageing, and Retirement in Europe.METHODS: Mortality risk associated with Comorbidity Index, Frailty Index, Frailty Phenotype, and subjective health was analysed using Cox regression. The extent to which health indicators modified individual mortality risk predictions was examined and the added ability to discriminate mortality risks was assessed.MAIN OUTCOME MEASURES: Three-year mortality risks, hazard ratios, change in individual mortality risks, three-year area under the receiver operating characteristic curve (AUC).RESULTS: Three-year mortality risks increased 41-folds within an age span of 50years. Hazard ratios per change in health indicator became less significant with increasing age (p-value<0·001). AUC for three-year mortality prediction based on age and sex was 76·9{\%} (95{\%} CI 75·5{\%} to 78·3{\%}). Information on health indicators modified individual three-year mortality risk predictions up to 30{\%}, both upwards and downwards, each adding <2{\%} discriminative power. The added discrimination ability of all health indicators gradually declined from an extra 4{\%} at age 50-59 to <1{\%} in the oldest old. Trends were similar for one-year mortality and not different between sexes, levels of education, and household income.CONCLUSION: Calendar age encompasses most of the discrimination ability to predict mortality. The added value of comorbidity, frailty, and subjective health to mortality predictions decreases with increasing age.",
keywords = "Journal Article",
author = "Sasmita Kusumastuti and Gerds, {Thomas Alexander} and Rikke Lund and Mortensen, {Erik Lykke} and Westendorp, {Rudi G. J.}",
note = "Copyright {\circledC} 2017 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.",
year = "2017",
month = "7",
doi = "10.1016/j.ejim.2017.05.016",
language = "English",
volume = "42",
pages = "29--38",
journal = "European Journal of Internal Medicine",
issn = "0953-6205",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Discrimination ability of comorbidity, frailty, and subjective health to predict mortality in community-dwelling older people

T2 - Population based prospective cohort study

AU - Kusumastuti, Sasmita

AU - Gerds, Thomas Alexander

AU - Lund, Rikke

AU - Mortensen, Erik Lykke

AU - Westendorp, Rudi G. J.

N1 - Copyright © 2017 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

PY - 2017/7

Y1 - 2017/7

N2 - OBJECTIVE: To investigate the added value of comorbidity, frailty, and subjective health to mortality predictions in community-dwelling older people and whether it changes with increasing age.PARTICIPANTS: 36,751 community-dwelling subjects aged 50-100 from the longitudinal Survey of Health, Ageing, and Retirement in Europe.METHODS: Mortality risk associated with Comorbidity Index, Frailty Index, Frailty Phenotype, and subjective health was analysed using Cox regression. The extent to which health indicators modified individual mortality risk predictions was examined and the added ability to discriminate mortality risks was assessed.MAIN OUTCOME MEASURES: Three-year mortality risks, hazard ratios, change in individual mortality risks, three-year area under the receiver operating characteristic curve (AUC).RESULTS: Three-year mortality risks increased 41-folds within an age span of 50years. Hazard ratios per change in health indicator became less significant with increasing age (p-value<0·001). AUC for three-year mortality prediction based on age and sex was 76·9% (95% CI 75·5% to 78·3%). Information on health indicators modified individual three-year mortality risk predictions up to 30%, both upwards and downwards, each adding <2% discriminative power. The added discrimination ability of all health indicators gradually declined from an extra 4% at age 50-59 to <1% in the oldest old. Trends were similar for one-year mortality and not different between sexes, levels of education, and household income.CONCLUSION: Calendar age encompasses most of the discrimination ability to predict mortality. The added value of comorbidity, frailty, and subjective health to mortality predictions decreases with increasing age.

AB - OBJECTIVE: To investigate the added value of comorbidity, frailty, and subjective health to mortality predictions in community-dwelling older people and whether it changes with increasing age.PARTICIPANTS: 36,751 community-dwelling subjects aged 50-100 from the longitudinal Survey of Health, Ageing, and Retirement in Europe.METHODS: Mortality risk associated with Comorbidity Index, Frailty Index, Frailty Phenotype, and subjective health was analysed using Cox regression. The extent to which health indicators modified individual mortality risk predictions was examined and the added ability to discriminate mortality risks was assessed.MAIN OUTCOME MEASURES: Three-year mortality risks, hazard ratios, change in individual mortality risks, three-year area under the receiver operating characteristic curve (AUC).RESULTS: Three-year mortality risks increased 41-folds within an age span of 50years. Hazard ratios per change in health indicator became less significant with increasing age (p-value<0·001). AUC for three-year mortality prediction based on age and sex was 76·9% (95% CI 75·5% to 78·3%). Information on health indicators modified individual three-year mortality risk predictions up to 30%, both upwards and downwards, each adding <2% discriminative power. The added discrimination ability of all health indicators gradually declined from an extra 4% at age 50-59 to <1% in the oldest old. Trends were similar for one-year mortality and not different between sexes, levels of education, and household income.CONCLUSION: Calendar age encompasses most of the discrimination ability to predict mortality. The added value of comorbidity, frailty, and subjective health to mortality predictions decreases with increasing age.

KW - Journal Article

U2 - 10.1016/j.ejim.2017.05.016

DO - 10.1016/j.ejim.2017.05.016

M3 - Journal article

VL - 42

SP - 29

EP - 38

JO - European Journal of Internal Medicine

JF - European Journal of Internal Medicine

SN - 0953-6205

ER -

ID: 180609254