Effects of treatment on IgE responses against parasite allergen-like proteins and immunity to reinfection in childhood schistosome and hookworm coinfections
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Effects of treatment on IgE responses against parasite allergen-like proteins and immunity to reinfection in childhood schistosome and hookworm coinfections. / Pinot de Moira, Angela; Jones, Frances M; Wilson, Shona; Tukahebwa, Edridah; Fitzsimmons, Colin M; Mwatha, Joseph K; Bethony, Jeffrey M; Kabatereine, Narcis B; Dunne, David W.
In: Infection and Immunity, Vol. 81, No. 1, 01.2013, p. 23-32.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effects of treatment on IgE responses against parasite allergen-like proteins and immunity to reinfection in childhood schistosome and hookworm coinfections
AU - Pinot de Moira, Angela
AU - Jones, Frances M
AU - Wilson, Shona
AU - Tukahebwa, Edridah
AU - Fitzsimmons, Colin M
AU - Mwatha, Joseph K
AU - Bethony, Jeffrey M
AU - Kabatereine, Narcis B
AU - Dunne, David W
PY - 2013/1
Y1 - 2013/1
N2 - Naturally occurring human immunity to both schistosomiasis and hookworm infection has been associated with IgE responses against parasite allergen-like proteins. Since the two helminths frequently coinfect the same individuals, there is growing advocacy for their concurrent treatment. However, both helminths are known to exert strong immunomodulatory effects; therefore, coinfected individuals could have immune responses different from those characteristically seen in monoinfected individuals. In this study, we measured changes in IgE, IgG1, and IgG4 responses to schistosome and hookworm antigens, including the allergen-like proteins Schistosoma mansoni tegumental-allergen-like 1 protein (SmTAL1), SmTAL2, and Necator americanus Ancylostoma-secreted protein-2 (Na-ASP-2), following concurrent treatment of schoolchildren coinfected with Schistosoma mansoni and hookworm. Antibody responses to schistosome egg (soluble egg antigen and SmTAL2) or somatic adult hookworm (AHW) antigens either decreased after treatment or were unchanged, whereas those to schistosome worm antigens (soluble worm antigen and SmTAL1) increased. The observed different effects of treatment likely reflect the different modes of drug action and sites of infection for these two helminths. Importantly, there was no evidence that the simultaneous treatment of coinfected children with praziquantel and albendazole affected schistosome- and hookworm-specific humoral responses differently from those characteristic of populations in which only one organism is endemic; schistosome- and hookworm-specific responses were not associated, and there was no evidence for cross-regulation. Posttreatment increases in the levels of IgE to schistosome worm antigens were associated with lower Schistosoma mansoni reinfection intensity, while no associations between humoral responses to AHW antigen and protection from hookworm reinfection were observed in this sample of school-aged children.
AB - Naturally occurring human immunity to both schistosomiasis and hookworm infection has been associated with IgE responses against parasite allergen-like proteins. Since the two helminths frequently coinfect the same individuals, there is growing advocacy for their concurrent treatment. However, both helminths are known to exert strong immunomodulatory effects; therefore, coinfected individuals could have immune responses different from those characteristically seen in monoinfected individuals. In this study, we measured changes in IgE, IgG1, and IgG4 responses to schistosome and hookworm antigens, including the allergen-like proteins Schistosoma mansoni tegumental-allergen-like 1 protein (SmTAL1), SmTAL2, and Necator americanus Ancylostoma-secreted protein-2 (Na-ASP-2), following concurrent treatment of schoolchildren coinfected with Schistosoma mansoni and hookworm. Antibody responses to schistosome egg (soluble egg antigen and SmTAL2) or somatic adult hookworm (AHW) antigens either decreased after treatment or were unchanged, whereas those to schistosome worm antigens (soluble worm antigen and SmTAL1) increased. The observed different effects of treatment likely reflect the different modes of drug action and sites of infection for these two helminths. Importantly, there was no evidence that the simultaneous treatment of coinfected children with praziquantel and albendazole affected schistosome- and hookworm-specific humoral responses differently from those characteristic of populations in which only one organism is endemic; schistosome- and hookworm-specific responses were not associated, and there was no evidence for cross-regulation. Posttreatment increases in the levels of IgE to schistosome worm antigens were associated with lower Schistosoma mansoni reinfection intensity, while no associations between humoral responses to AHW antigen and protection from hookworm reinfection were observed in this sample of school-aged children.
KW - Adolescent
KW - Albendazole/therapeutic use
KW - Allergens/immunology
KW - Ancylostomatoidea/drug effects
KW - Animals
KW - Antibodies, Helminth/immunology
KW - Antigens, Helminth/immunology
KW - Child
KW - Coinfection/drug therapy
KW - Female
KW - Hookworm Infections/drug therapy
KW - Humans
KW - Immunity, Humoral/immunology
KW - Immunoglobulin E/immunology
KW - Immunoglobulin G/immunology
KW - Immunologic Factors/immunology
KW - Male
KW - Mice
KW - Praziquantel/therapeutic use
KW - Schistosoma mansoni/drug effects
KW - Schistosomiasis mansoni/drug therapy
U2 - 10.1128/IAI.00748-12
DO - 10.1128/IAI.00748-12
M3 - Journal article
C2 - 23071136
VL - 81
SP - 23
EP - 32
JO - Infection and Immunity
JF - Infection and Immunity
SN - 0019-9567
IS - 1
ER -
ID: 314968562