TY - JOUR

T1 - Exposure to different residential indoor characteristics during childhood and asthma in adolescence

T2 - a latent class analysis of the Danish National Birth Cohort

AU - Keller, Amélie

AU - Groot, Jonathan

AU - Clippet-Jensen, Clara

AU - Pinot de Moira, Angela

AU - Pedersen, Marie

AU - Sigsgaard, Torben

AU - Loft, Steffen

AU - Budtz-Jørgensen, Esben

AU - Nybo Andersen, Anne Marie

N1 - Publisher Copyright: © 2023, The Author(s).

PY - 2024

Y1 - 2024

N2 - Background: Many residential indoor environments may have an impact on children’s respiratory health. Objectives: The aims of this study were to identify latent classes of children from the Danish National Birth Cohort (DNBC) who share similar patterns of exposure to indoor home characteristics, and to examine the association between membership in the latent classes and asthma in adolescence. Methods: We included data on residential indoor characteristics of offspring from the DNBC whose mothers had responded to the child’s 11-year follow-up and who had data on asthma from the 18-year follow-up. Number of classes and associations were estimated using latent class analysis. To account for sample selection, we applied inverse probability weighting. Results: Our final model included five latent classes. The probability of current asthma at 18 years was highest among individuals in class one with higher clustering on household dampness (9, 95%CI 0.06–0.13). Individuals in class four (with higher clustering on pets ownership and living in a farm) had a lower risk of current asthma at age 18 compared to individuals in class one (with higher clustering on household dampness) (OR 0.53 (95%CI 0.32–0.88), p =.01). Conclusion: Our findings suggest that, in a high-income country such as Denmark, groups of adolescents growing up in homes with mold and moisture during mid-childhood might be at increased risk of current asthma at age 18. Adolescents who grew-up in a farmhouse and who were exposed to pets seem less likely to suffer from asthma by age 18.

AB - Background: Many residential indoor environments may have an impact on children’s respiratory health. Objectives: The aims of this study were to identify latent classes of children from the Danish National Birth Cohort (DNBC) who share similar patterns of exposure to indoor home characteristics, and to examine the association between membership in the latent classes and asthma in adolescence. Methods: We included data on residential indoor characteristics of offspring from the DNBC whose mothers had responded to the child’s 11-year follow-up and who had data on asthma from the 18-year follow-up. Number of classes and associations were estimated using latent class analysis. To account for sample selection, we applied inverse probability weighting. Results: Our final model included five latent classes. The probability of current asthma at 18 years was highest among individuals in class one with higher clustering on household dampness (9, 95%CI 0.06–0.13). Individuals in class four (with higher clustering on pets ownership and living in a farm) had a lower risk of current asthma at age 18 compared to individuals in class one (with higher clustering on household dampness) (OR 0.53 (95%CI 0.32–0.88), p =.01). Conclusion: Our findings suggest that, in a high-income country such as Denmark, groups of adolescents growing up in homes with mold and moisture during mid-childhood might be at increased risk of current asthma at age 18. Adolescents who grew-up in a farmhouse and who were exposed to pets seem less likely to suffer from asthma by age 18.

KW - Asthma

KW - Danish National Birth Cohort

KW - Environmental epidemiology

KW - Home characteristics

KW - Indoor air pollution

U2 - 10.1007/s10654-023-01051-y

DO - 10.1007/s10654-023-01051-y

M3 - Journal article

C2 - 37865616

AN - SCOPUS:85174607943

VL - 39

SP - 51

EP - 65

JO - European Journal of Epidemiology

JF - European Journal of Epidemiology

SN - 0393-2990

ER -