Exposure to tobacco smoke in utero and the risk of stillbirth and death in the first year of life
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Exposure to tobacco smoke in utero and the risk of stillbirth and death in the first year of life. / Wisborg, K; Kesmodel, U; Henriksen, T B; Olsen, S F; Secher, N J.
In: American Journal of Epidemiology, Vol. 154, No. 4, 2001, p. 322-7.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Exposure to tobacco smoke in utero and the risk of stillbirth and death in the first year of life
AU - Wisborg, K
AU - Kesmodel, U
AU - Henriksen, T B
AU - Olsen, S F
AU - Secher, N J
PY - 2001
Y1 - 2001
N2 - The authors examined the association between exposure to tobacco smoke in utero and the risk of stillbirth and infant death in a cohort of 25,102 singleton children of pregnant women scheduled to deliver at Aarhus University Hospital, Aarhus, Denmark, from September 1989 to August 1996. Exposure to tobacco smoke in utero was associated with an increased risk of stillbirth (odds ratio = 2.0, 95% confidence interval: 1.4, 2.9), and infant mortality was almost doubled in children born to women who had smoked during pregnancy compared with children of nonsmokers (odds ratio = 1.8, 95% confidence interval: 1.3, 2.6). Among children of women who stopped smoking during the first trimester, stillbirth and infant mortality was comparable with that in children of women who had been nonsmokers from the beginning of pregnancy. Conclusions were not changed after adjustment in a logistic regression model for the sex of the child; parity; or maternal age, height, weight, marital status, years of education, occupational status, and alcohol and caffeine intake during pregnancy. Approximately 25% of all stillbirths and 20% of all infant deaths in a population with 30% pregnant smokers could be avoided if all pregnant smokers stopped smoking by the sixteenth week of gestation.
AB - The authors examined the association between exposure to tobacco smoke in utero and the risk of stillbirth and infant death in a cohort of 25,102 singleton children of pregnant women scheduled to deliver at Aarhus University Hospital, Aarhus, Denmark, from September 1989 to August 1996. Exposure to tobacco smoke in utero was associated with an increased risk of stillbirth (odds ratio = 2.0, 95% confidence interval: 1.4, 2.9), and infant mortality was almost doubled in children born to women who had smoked during pregnancy compared with children of nonsmokers (odds ratio = 1.8, 95% confidence interval: 1.3, 2.6). Among children of women who stopped smoking during the first trimester, stillbirth and infant mortality was comparable with that in children of women who had been nonsmokers from the beginning of pregnancy. Conclusions were not changed after adjustment in a logistic regression model for the sex of the child; parity; or maternal age, height, weight, marital status, years of education, occupational status, and alcohol and caffeine intake during pregnancy. Approximately 25% of all stillbirths and 20% of all infant deaths in a population with 30% pregnant smokers could be avoided if all pregnant smokers stopped smoking by the sixteenth week of gestation.
KW - Denmark/epidemiology
KW - Female
KW - Fetal Death/chemically induced
KW - Humans
KW - Infant
KW - Infant Mortality
KW - Infant, Newborn
KW - Logistic Models
KW - Pregnancy
KW - Pregnancy Outcome/epidemiology
KW - Prenatal Exposure Delayed Effects
KW - Proportional Hazards Models
KW - Risk Factors
KW - Smoking Cessation
KW - Tobacco Smoke Pollution/adverse effects
U2 - 10.1093/aje/154.4.322
DO - 10.1093/aje/154.4.322
M3 - Journal article
C2 - 11495855
VL - 154
SP - 322
EP - 327
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
SN - 0002-9262
IS - 4
ER -
ID: 307748872