Extra vitamin D from fortification and the risk of preeclampsia: The D-tect Study
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Extra vitamin D from fortification and the risk of preeclampsia : The D-tect Study. / Stougaard, Maria; Damm, Peter; Frederiksen, Peder; Jacobsen, Ramune; Heitmann, Berit Lilienthal.
In: PLOS ONE, Vol. 13, No. 1, e0191288, 2018.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Extra vitamin D from fortification and the risk of preeclampsia
T2 - The D-tect Study
AU - Stougaard, Maria
AU - Damm, Peter
AU - Frederiksen, Peder
AU - Jacobsen, Ramune
AU - Heitmann, Berit Lilienthal
PY - 2018
Y1 - 2018
N2 - The objective of the study was to examine if exposure to extra vitamin D from food fortification was associated with a decrease in the risk of preeclampsia. The study was based on a natural experiment exploring the effect of the abolition of the Danish mandatory vitamin D fortification of margarine in 1985. The effect of the extra vitamin D (1.25μg vitamin D/100 g margarine) was examined by comparing preeclampsia risk in women who have been exposed or unexposed to extra vitamin D from the fortified margarine during pregnancy, and who gave birth in the period from June 1983 to August 1988. The Danish National Patient Registry allowed the identification of pregnancies complicated by preeclampsia. The study included 73,237 women who gave birth during 1983-1988. We found no association between exposure to vitamin D fortification during pregnancy and the risk of any of the pregnancy related hypertensive disorders, including preeclampsia: Odds ratios (OR, 95%) for all hypertensive pregnancy related disorders among exposed vs. unexposed women was (OR 1.04, 95%CI: 0.98,1.10). In conclusion, the extra vitamin D from the mandatory vitamin D fortification did not influence the risk of preeclampsia.
AB - The objective of the study was to examine if exposure to extra vitamin D from food fortification was associated with a decrease in the risk of preeclampsia. The study was based on a natural experiment exploring the effect of the abolition of the Danish mandatory vitamin D fortification of margarine in 1985. The effect of the extra vitamin D (1.25μg vitamin D/100 g margarine) was examined by comparing preeclampsia risk in women who have been exposed or unexposed to extra vitamin D from the fortified margarine during pregnancy, and who gave birth in the period from June 1983 to August 1988. The Danish National Patient Registry allowed the identification of pregnancies complicated by preeclampsia. The study included 73,237 women who gave birth during 1983-1988. We found no association between exposure to vitamin D fortification during pregnancy and the risk of any of the pregnancy related hypertensive disorders, including preeclampsia: Odds ratios (OR, 95%) for all hypertensive pregnancy related disorders among exposed vs. unexposed women was (OR 1.04, 95%CI: 0.98,1.10). In conclusion, the extra vitamin D from the mandatory vitamin D fortification did not influence the risk of preeclampsia.
KW - Adult
KW - Dose-Response Relationship, Drug
KW - Female
KW - Food, Fortified
KW - Humans
KW - Pre-Eclampsia/prevention & control
KW - Pregnancy
KW - Risk
KW - Vitamin D/pharmacology
KW - Young Adult
U2 - 10.1371/journal.pone.0191288
DO - 10.1371/journal.pone.0191288
M3 - Journal article
C2 - 29370249
VL - 13
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 1
M1 - e0191288
ER -
ID: 210836594