Factors Associated With and Outcomes After Ventricular Fibrillation Before and During Primary Angioplasty in Patients With ST-Segment Elevation Myocardial Infarction
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Factors Associated With and Outcomes After Ventricular Fibrillation Before and During Primary Angioplasty in Patients With ST-Segment Elevation Myocardial Infarction. / Jabbari, Reza; Risgaard, Bjarke; Fosbøl, Emil Loldrup; Scheike, Thomas; Philbert, Berit Thornvig; Winkel, Bo Gregers; Albert, Christine M.; Glinge, Charlotte; Ahtarovski, Kiril A.; Haunso, Stig; Køber, Lars Valeur; Jørgensen, Erik; Pedersen, Frants; Tfelt-Hansen, Jacob; Engstrøm, Thomas.
In: American Journal of Cardiology, Vol. 116, No. 5, 01.09.2015, p. 678-685.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Factors Associated With and Outcomes After Ventricular Fibrillation Before and During Primary Angioplasty in Patients With ST-Segment Elevation Myocardial Infarction
AU - Jabbari, Reza
AU - Risgaard, Bjarke
AU - Fosbøl, Emil Loldrup
AU - Scheike, Thomas
AU - Philbert, Berit Thornvig
AU - Winkel, Bo Gregers
AU - Albert, Christine M.
AU - Glinge, Charlotte
AU - Ahtarovski, Kiril A.
AU - Haunso, Stig
AU - Køber, Lars Valeur
AU - Jørgensen, Erik
AU - Pedersen, Frants
AU - Tfelt-Hansen, Jacob
AU - Engstrøm, Thomas
PY - 2015/9/1
Y1 - 2015/9/1
N2 - We aimed to assess the risk factors and outcome of ventricular fibrillation (VF) before and duringprimary percutaneous coronary intervention (PPCI) in patients with ST-segment elevationmyocardial infarction. From 1999 to 2012, we consecutively enrolled 5,373 patients withST-segment elevation myocardial infarction. In total, 410 of the patients had VF before and 88had VF during PPCI. During a mean follow-up of 4.2 years, 1,196 subjects died. A logisticregression model identified younger age, anterior infarct, Killip class >I at admission, and apreprocedural Thrombolysis In Myocardial Infarction flow grade of 0 to I to be significantlyassociated with VF before PPCI, whereas inferior infarct, a preprocedural Thrombolysis InMyocardial Infarction flow grade of 0 to I, and Killip class >I at admission were significantlyassociated with VF during PPCI. All-cause mortality was evaluated using the Cox regressionmodel. Compared with the patients without VF, those with VF before or during PPCI had asignificantly increased 30-day mortality, with an adjusted hazard ratio [ 3.40 (95% confidenceinterval 1.70 to 6.70) and 4.20 (95% confidence interval 1.30 to 13.30), respectively. Importantly,there was no tendency of 30-day mortality difference between VF before and during PPCI (p [0.170). In patients with VF before or during PPCI who survived for at least 30 days, there was noincrease in the long-term mortality. In conclusion, our data suggest that 30-day mortality is thesame for patients with VF before PPCI compared with VF during PPCI, and the occurrence of VFbefore or during PPCI was associated with increased 30-day mortality but not with long-termmortality.
AB - We aimed to assess the risk factors and outcome of ventricular fibrillation (VF) before and duringprimary percutaneous coronary intervention (PPCI) in patients with ST-segment elevationmyocardial infarction. From 1999 to 2012, we consecutively enrolled 5,373 patients withST-segment elevation myocardial infarction. In total, 410 of the patients had VF before and 88had VF during PPCI. During a mean follow-up of 4.2 years, 1,196 subjects died. A logisticregression model identified younger age, anterior infarct, Killip class >I at admission, and apreprocedural Thrombolysis In Myocardial Infarction flow grade of 0 to I to be significantlyassociated with VF before PPCI, whereas inferior infarct, a preprocedural Thrombolysis InMyocardial Infarction flow grade of 0 to I, and Killip class >I at admission were significantlyassociated with VF during PPCI. All-cause mortality was evaluated using the Cox regressionmodel. Compared with the patients without VF, those with VF before or during PPCI had asignificantly increased 30-day mortality, with an adjusted hazard ratio [ 3.40 (95% confidenceinterval 1.70 to 6.70) and 4.20 (95% confidence interval 1.30 to 13.30), respectively. Importantly,there was no tendency of 30-day mortality difference between VF before and during PPCI (p [0.170). In patients with VF before or during PPCI who survived for at least 30 days, there was noincrease in the long-term mortality. In conclusion, our data suggest that 30-day mortality is thesame for patients with VF before PPCI compared with VF during PPCI, and the occurrence of VFbefore or during PPCI was associated with increased 30-day mortality but not with long-termmortality.
U2 - 10.1016/j.amjcard.2015.05.037
DO - 10.1016/j.amjcard.2015.05.037
M3 - Journal article
C2 - 26150175
VL - 116
SP - 678
EP - 685
JO - Am. J. Cardiol.
JF - Am. J. Cardiol.
SN - 0002-9149
IS - 5
ER -
ID: 160443147