Familial Longevity Is Not Associated with Major Differences in the Hypothalamic–Pituitary–Gonadal Axis in Healthy Middle-Aged Men

Research output: Contribution to journalJournal articleResearchpeer-review

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Familial Longevity Is Not Associated with Major Differences in the Hypothalamic–Pituitary–Gonadal Axis in Healthy Middle-Aged Men. / van der Spoel, Evie; Roelfsema, Ferdinand; Jansen, Steffy W.; Akintola, Abimbola A.; Ballieux, Bart E.; Cobbaert, Christa M.; Blauw, Gerard J.; Slagboom, P. Eline; Westendorp, Rudi G. J.; Piji, Hanno; van Heemst, Diana.

In: Frontiers in Endocrinology, Vol. 7, 143, 09.11.2016, p. 1-7.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

van der Spoel, E, Roelfsema, F, Jansen, SW, Akintola, AA, Ballieux, BE, Cobbaert, CM, Blauw, GJ, Slagboom, PE, Westendorp, RGJ, Piji, H & van Heemst, D 2016, 'Familial Longevity Is Not Associated with Major Differences in the Hypothalamic–Pituitary–Gonadal Axis in Healthy Middle-Aged Men', Frontiers in Endocrinology, vol. 7, 143, pp. 1-7. https://doi.org/10.3389/fendo.2016.00143

APA

van der Spoel, E., Roelfsema, F., Jansen, S. W., Akintola, A. A., Ballieux, B. E., Cobbaert, C. M., ... van Heemst, D. (2016). Familial Longevity Is Not Associated with Major Differences in the Hypothalamic–Pituitary–Gonadal Axis in Healthy Middle-Aged Men. Frontiers in Endocrinology, 7, 1-7. [143]. https://doi.org/10.3389/fendo.2016.00143

Vancouver

van der Spoel E, Roelfsema F, Jansen SW, Akintola AA, Ballieux BE, Cobbaert CM et al. Familial Longevity Is Not Associated with Major Differences in the Hypothalamic–Pituitary–Gonadal Axis in Healthy Middle-Aged Men. Frontiers in Endocrinology. 2016 Nov 9;7:1-7. 143. https://doi.org/10.3389/fendo.2016.00143

Author

van der Spoel, Evie ; Roelfsema, Ferdinand ; Jansen, Steffy W. ; Akintola, Abimbola A. ; Ballieux, Bart E. ; Cobbaert, Christa M. ; Blauw, Gerard J. ; Slagboom, P. Eline ; Westendorp, Rudi G. J. ; Piji, Hanno ; van Heemst, Diana. / Familial Longevity Is Not Associated with Major Differences in the Hypothalamic–Pituitary–Gonadal Axis in Healthy Middle-Aged Men. In: Frontiers in Endocrinology. 2016 ; Vol. 7. pp. 1-7.

Bibtex

@article{0d8432af90884d3db2f155581ee3a5e2,
title = "Familial Longevity Is Not Associated with Major Differences in the Hypothalamic–Pituitary–Gonadal Axis in Healthy Middle-Aged Men",
abstract = "Context: A trade-off between fertility and longevity possibly exists. The association of the male hypothalamic–pituitary–gonadal (HPG) axis with familial longevity has not yet been investigated.Objective: To study 24-h hormone concentration profiles of the HPG axis in men enriched for familial longevity and controls.Design: We frequently sampled blood over 24 h in 10 healthy middle-aged male offspring of nonagenarian participants from the Leiden Longevity Study together with 10 male age-matched controls. Individual 24-h luteinizing hormone (LH) and testosterone concentration profiles were analyzed by deconvolution analyses to estimate secretion parameters. Furthermore, the temporal relationship between LH and testosterone was assessed by cross-correlation analysis. We used (cross-)approximate entropy to quantify the strength of feedback and/or feedforward control of LH and testosterone secretion.Results: Mean [95{\%} confidence interval (CI)] total LH secretion of the offspring was 212 (156–268) U/L/24 h, which did not differ significantly (p = 0.51) from the total LH secretion of controls [186 (130–242) U/L/24 h]. Likewise, mean (95{\%} CI) total testosterone secretion of the offspring [806 (671–941) nmol/L/24 h] and controls [811 (676–947) nmol/L/24 h] were similar (p = 0.95). Other parameters of LH and testosterone secretion were also not significantly different between offspring and controls. The temporal relationship between LH and testosterone and the strength of feedforward/feedback regulation within the HPG axis were similar between offspring of long-lived families and controls.Conclusion: This relatively small study suggests that in healthy male middle-aged participants, familial longevity is not associated with major differences in the HPG axis. Selection on both fertility and health may in part explain the results.",
keywords = "luteinizing hormone, testosterone, hypothalamic-pituitary-gonadal axis, familial longevity, hormone secretion, approximate entropy, temporal correlation",
author = "{van der Spoel}, Evie and Ferdinand Roelfsema and Jansen, {Steffy W.} and Akintola, {Abimbola A.} and Ballieux, {Bart E.} and Cobbaert, {Christa M.} and Blauw, {Gerard J.} and Slagboom, {P. Eline} and Westendorp, {Rudi G. J.} and Hanno Piji and {van Heemst}, Diana",
year = "2016",
month = "11",
day = "9",
doi = "10.3389/fendo.2016.00143",
language = "English",
volume = "7",
pages = "1--7",
journal = "Frontiers in Endocrinology",
issn = "1664-2392",
publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - Familial Longevity Is Not Associated with Major Differences in the Hypothalamic–Pituitary–Gonadal Axis in Healthy Middle-Aged Men

AU - van der Spoel, Evie

AU - Roelfsema, Ferdinand

AU - Jansen, Steffy W.

AU - Akintola, Abimbola A.

AU - Ballieux, Bart E.

AU - Cobbaert, Christa M.

AU - Blauw, Gerard J.

AU - Slagboom, P. Eline

AU - Westendorp, Rudi G. J.

AU - Piji, Hanno

AU - van Heemst, Diana

PY - 2016/11/9

Y1 - 2016/11/9

N2 - Context: A trade-off between fertility and longevity possibly exists. The association of the male hypothalamic–pituitary–gonadal (HPG) axis with familial longevity has not yet been investigated.Objective: To study 24-h hormone concentration profiles of the HPG axis in men enriched for familial longevity and controls.Design: We frequently sampled blood over 24 h in 10 healthy middle-aged male offspring of nonagenarian participants from the Leiden Longevity Study together with 10 male age-matched controls. Individual 24-h luteinizing hormone (LH) and testosterone concentration profiles were analyzed by deconvolution analyses to estimate secretion parameters. Furthermore, the temporal relationship between LH and testosterone was assessed by cross-correlation analysis. We used (cross-)approximate entropy to quantify the strength of feedback and/or feedforward control of LH and testosterone secretion.Results: Mean [95% confidence interval (CI)] total LH secretion of the offspring was 212 (156–268) U/L/24 h, which did not differ significantly (p = 0.51) from the total LH secretion of controls [186 (130–242) U/L/24 h]. Likewise, mean (95% CI) total testosterone secretion of the offspring [806 (671–941) nmol/L/24 h] and controls [811 (676–947) nmol/L/24 h] were similar (p = 0.95). Other parameters of LH and testosterone secretion were also not significantly different between offspring and controls. The temporal relationship between LH and testosterone and the strength of feedforward/feedback regulation within the HPG axis were similar between offspring of long-lived families and controls.Conclusion: This relatively small study suggests that in healthy male middle-aged participants, familial longevity is not associated with major differences in the HPG axis. Selection on both fertility and health may in part explain the results.

AB - Context: A trade-off between fertility and longevity possibly exists. The association of the male hypothalamic–pituitary–gonadal (HPG) axis with familial longevity has not yet been investigated.Objective: To study 24-h hormone concentration profiles of the HPG axis in men enriched for familial longevity and controls.Design: We frequently sampled blood over 24 h in 10 healthy middle-aged male offspring of nonagenarian participants from the Leiden Longevity Study together with 10 male age-matched controls. Individual 24-h luteinizing hormone (LH) and testosterone concentration profiles were analyzed by deconvolution analyses to estimate secretion parameters. Furthermore, the temporal relationship between LH and testosterone was assessed by cross-correlation analysis. We used (cross-)approximate entropy to quantify the strength of feedback and/or feedforward control of LH and testosterone secretion.Results: Mean [95% confidence interval (CI)] total LH secretion of the offspring was 212 (156–268) U/L/24 h, which did not differ significantly (p = 0.51) from the total LH secretion of controls [186 (130–242) U/L/24 h]. Likewise, mean (95% CI) total testosterone secretion of the offspring [806 (671–941) nmol/L/24 h] and controls [811 (676–947) nmol/L/24 h] were similar (p = 0.95). Other parameters of LH and testosterone secretion were also not significantly different between offspring and controls. The temporal relationship between LH and testosterone and the strength of feedforward/feedback regulation within the HPG axis were similar between offspring of long-lived families and controls.Conclusion: This relatively small study suggests that in healthy male middle-aged participants, familial longevity is not associated with major differences in the HPG axis. Selection on both fertility and health may in part explain the results.

KW - luteinizing hormone

KW - testosterone

KW - hypothalamic-pituitary-gonadal axis

KW - familial longevity

KW - hormone secretion

KW - approximate entropy

KW - temporal correlation

U2 - 10.3389/fendo.2016.00143

DO - 10.3389/fendo.2016.00143

M3 - Journal article

VL - 7

SP - 1

EP - 7

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

SN - 1664-2392

M1 - 143

ER -

ID: 169761522