Fc Gamma Receptor 3B (FCGR3Bc.233C>A-rs5030738) Polymorphism Modifies the Protective Effect of Malaria Specific Antibodies in Ghanaian Children

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Fc Gamma Receptor 3B (FCGR3Bc.233C>A-rs5030738) Polymorphism Modifies the Protective Effect of Malaria Specific Antibodies in Ghanaian Children. / Adu, Bright; Jepsen, Micha Phill Grønholm; Gerds, Thomas A; Kyei-Baafour, Eric; Christiansen, Michael; Dodoo, Daniel; Theisen, Michael.

In: The Journal of Infectious Diseases, Vol. 209, No. 2, 01.2014, p. 285-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Adu, B, Jepsen, MPG, Gerds, TA, Kyei-Baafour, E, Christiansen, M, Dodoo, D & Theisen, M 2014, 'Fc Gamma Receptor 3B (FCGR3Bc.233C>A-rs5030738) Polymorphism Modifies the Protective Effect of Malaria Specific Antibodies in Ghanaian Children', The Journal of Infectious Diseases, vol. 209, no. 2, pp. 285-9. https://doi.org/10.1093/infdis/jit422

APA

Adu, B., Jepsen, M. P. G., Gerds, T. A., Kyei-Baafour, E., Christiansen, M., Dodoo, D., & Theisen, M. (2014). Fc Gamma Receptor 3B (FCGR3Bc.233C>A-rs5030738) Polymorphism Modifies the Protective Effect of Malaria Specific Antibodies in Ghanaian Children. The Journal of Infectious Diseases, 209(2), 285-9. https://doi.org/10.1093/infdis/jit422

Vancouver

Adu B, Jepsen MPG, Gerds TA, Kyei-Baafour E, Christiansen M, Dodoo D et al. Fc Gamma Receptor 3B (FCGR3Bc.233C>A-rs5030738) Polymorphism Modifies the Protective Effect of Malaria Specific Antibodies in Ghanaian Children. The Journal of Infectious Diseases. 2014 Jan;209(2):285-9. https://doi.org/10.1093/infdis/jit422

Author

Adu, Bright ; Jepsen, Micha Phill Grønholm ; Gerds, Thomas A ; Kyei-Baafour, Eric ; Christiansen, Michael ; Dodoo, Daniel ; Theisen, Michael. / Fc Gamma Receptor 3B (FCGR3Bc.233C>A-rs5030738) Polymorphism Modifies the Protective Effect of Malaria Specific Antibodies in Ghanaian Children. In: The Journal of Infectious Diseases. 2014 ; Vol. 209, No. 2. pp. 285-9.

Bibtex

@article{aab9ee207e464a65bae3034fd121113a,
title = "Fc Gamma Receptor 3B (FCGR3Bc.233C>A-rs5030738) Polymorphism Modifies the Protective Effect of Malaria Specific Antibodies in Ghanaian Children",
abstract = "Immunoglobulin G (IgG) cross-linking with Fc gamma receptor IIIB (FcγRIIIB) triggers neutrophil degranulation, releasing reactive oxygen species with high levels associated with protection against malaria. The FCGR3B-c.233C>A polymorphism thought to influence the interaction between IgG and FcγRIIIB was recently associated with malaria. We studied the statistical interaction between glutamate rich protein antibodies and FCGR3B-c.233C>A genotypes on risk of malaria in a cohort of Ghanaian children. The absolute risk of malaria decreased more rapidly with increasing antibody levels for 233AA/AC individuals compared with 233CC children. This genotype related effect modification may significantly influence malaria sero-epidemiological and vaccine trial studies.",
author = "Bright Adu and Jepsen, {Micha Phill Gr{\o}nholm} and Gerds, {Thomas A} and Eric Kyei-Baafour and Michael Christiansen and Daniel Dodoo and Michael Theisen",
year = "2014",
month = jan,
doi = "10.1093/infdis/jit422",
language = "English",
volume = "209",
pages = "285--9",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Fc Gamma Receptor 3B (FCGR3Bc.233C>A-rs5030738) Polymorphism Modifies the Protective Effect of Malaria Specific Antibodies in Ghanaian Children

AU - Adu, Bright

AU - Jepsen, Micha Phill Grønholm

AU - Gerds, Thomas A

AU - Kyei-Baafour, Eric

AU - Christiansen, Michael

AU - Dodoo, Daniel

AU - Theisen, Michael

PY - 2014/1

Y1 - 2014/1

N2 - Immunoglobulin G (IgG) cross-linking with Fc gamma receptor IIIB (FcγRIIIB) triggers neutrophil degranulation, releasing reactive oxygen species with high levels associated with protection against malaria. The FCGR3B-c.233C>A polymorphism thought to influence the interaction between IgG and FcγRIIIB was recently associated with malaria. We studied the statistical interaction between glutamate rich protein antibodies and FCGR3B-c.233C>A genotypes on risk of malaria in a cohort of Ghanaian children. The absolute risk of malaria decreased more rapidly with increasing antibody levels for 233AA/AC individuals compared with 233CC children. This genotype related effect modification may significantly influence malaria sero-epidemiological and vaccine trial studies.

AB - Immunoglobulin G (IgG) cross-linking with Fc gamma receptor IIIB (FcγRIIIB) triggers neutrophil degranulation, releasing reactive oxygen species with high levels associated with protection against malaria. The FCGR3B-c.233C>A polymorphism thought to influence the interaction between IgG and FcγRIIIB was recently associated with malaria. We studied the statistical interaction between glutamate rich protein antibodies and FCGR3B-c.233C>A genotypes on risk of malaria in a cohort of Ghanaian children. The absolute risk of malaria decreased more rapidly with increasing antibody levels for 233AA/AC individuals compared with 233CC children. This genotype related effect modification may significantly influence malaria sero-epidemiological and vaccine trial studies.

U2 - 10.1093/infdis/jit422

DO - 10.1093/infdis/jit422

M3 - Journal article

C2 - 23935200

VL - 209

SP - 285

EP - 289

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 2

ER -

ID: 95983924