FEV1 is a stronger mortality predictor than FVC in patients with moderate copd and with an increased risk for cardiovascular disease

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

FEV1 is a stronger mortality predictor than FVC in patients with moderate copd and with an increased risk for cardiovascular disease. / Bikov, Andras; Lange, Peter; Anderson, Julie A.; Brook, Robert D.; Calverley, Peter M.A.; Celli, Bartolome R.; Cowans, Nicholas J.; Crim, Courtney; Dixon, Ian J.; Martinez, Fernando J.; Newby, David E.; Yates, Julie C.; Vestbo, Jørgen.

In: International Journal of COPD, Vol. 15, 2020, p. 1135-1142.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bikov, A, Lange, P, Anderson, JA, Brook, RD, Calverley, PMA, Celli, BR, Cowans, NJ, Crim, C, Dixon, IJ, Martinez, FJ, Newby, DE, Yates, JC & Vestbo, J 2020, 'FEV1 is a stronger mortality predictor than FVC in patients with moderate copd and with an increased risk for cardiovascular disease', International Journal of COPD, vol. 15, pp. 1135-1142. https://doi.org/10.2147/COPD.S242809

APA

Bikov, A., Lange, P., Anderson, J. A., Brook, R. D., Calverley, P. M. A., Celli, B. R., Cowans, N. J., Crim, C., Dixon, I. J., Martinez, F. J., Newby, D. E., Yates, J. C., & Vestbo, J. (2020). FEV1 is a stronger mortality predictor than FVC in patients with moderate copd and with an increased risk for cardiovascular disease. International Journal of COPD, 15, 1135-1142. https://doi.org/10.2147/COPD.S242809

Vancouver

Bikov A, Lange P, Anderson JA, Brook RD, Calverley PMA, Celli BR et al. FEV1 is a stronger mortality predictor than FVC in patients with moderate copd and with an increased risk for cardiovascular disease. International Journal of COPD. 2020;15:1135-1142. https://doi.org/10.2147/COPD.S242809

Author

Bikov, Andras ; Lange, Peter ; Anderson, Julie A. ; Brook, Robert D. ; Calverley, Peter M.A. ; Celli, Bartolome R. ; Cowans, Nicholas J. ; Crim, Courtney ; Dixon, Ian J. ; Martinez, Fernando J. ; Newby, David E. ; Yates, Julie C. ; Vestbo, Jørgen. / FEV1 is a stronger mortality predictor than FVC in patients with moderate copd and with an increased risk for cardiovascular disease. In: International Journal of COPD. 2020 ; Vol. 15. pp. 1135-1142.

Bibtex

@article{18707a74a2ea456b84ac298392d7eff3,
title = "FEV1 is a stronger mortality predictor than FVC in patients with moderate copd and with an increased risk for cardiovascular disease",
abstract = "Purpose: Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death worldwide. Impaired lung function is associated with heightened risk for death, cardiovascular events, and COPD exacerbations. However, it is unclear if forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) differ in predictive value. Patients and Methods: Data from 16,485 participants in the Study to Understand Mortality and Morbidity (SUMMIT) in COPD were analyzed. Patients were grouped into quintiles for each lung function parameter (FEV1 %predicted, FVC %predicted, FEV1/FVC). The four highest quintiles (Q2–Q5) were compared to the lowest (Q1) to assess their relationship with all-cause mortality, cardiovascular events, and moderate-to-severe and severe exacerbations. Cox-regression was used, adjusted for age, sex, ethnicity, body-mass index, smoking status, previous exacerbations, cardiovascular disease, treatment, and modified Medical Research Council dyspnea score. Results: Compared to Q1 (<53.5% FEV predicted), increasing FEV quintiles (Q2 53.5–457.5% 1 1 predicted, Q3 57.5–461.6% predicted, Q4 61.6–465.8% predicted, and Q5 ≥65.8%) were all associated with significantly decreased all-cause mortality (20% (4–34%), 28% (13–40%), 23% (7–36%), and 30% (15–42%) risk reduction, respectively). In contrast, a significant risk reduction (21% (4–35%)) was seen only between Q1 and Q5 quintiles of FVC. Neither FEV1 nor FVC was associated with cardiovascular risk. Increased FEV1 and FEV1/FVC quintiles were also associated with the reduction of moderate-to-severe and severe exacerbations while, surprisingly, the highest FVC quintile was related to the heightened exacerbation risk (28% (8–52%) risk increase). Conclusion: Our results suggest that FEV1 is a stronger predictor for all-cause mortality than FVC in moderate COPD patients with heightened cardiovascular risk and that subjects with moderate COPD have very different risks.",
keywords = "Airflow limitation, Cardiovascular risk, Death rate, Exacerbation, Lung function, Lung volumes",
author = "Andras Bikov and Peter Lange and Anderson, {Julie A.} and Brook, {Robert D.} and Calverley, {Peter M.A.} and Celli, {Bartolome R.} and Cowans, {Nicholas J.} and Courtney Crim and Dixon, {Ian J.} and Martinez, {Fernando J.} and Newby, {David E.} and Yates, {Julie C.} and J{\o}rgen Vestbo",
year = "2020",
doi = "10.2147/COPD.S242809",
language = "English",
volume = "15",
pages = "1135--1142",
journal = "International Journal of COPD",
issn = "1178-2005",
publisher = "Dove Medical Press Ltd",

}

RIS

TY - JOUR

T1 - FEV1 is a stronger mortality predictor than FVC in patients with moderate copd and with an increased risk for cardiovascular disease

AU - Bikov, Andras

AU - Lange, Peter

AU - Anderson, Julie A.

AU - Brook, Robert D.

AU - Calverley, Peter M.A.

AU - Celli, Bartolome R.

AU - Cowans, Nicholas J.

AU - Crim, Courtney

AU - Dixon, Ian J.

AU - Martinez, Fernando J.

AU - Newby, David E.

AU - Yates, Julie C.

AU - Vestbo, Jørgen

PY - 2020

Y1 - 2020

N2 - Purpose: Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death worldwide. Impaired lung function is associated with heightened risk for death, cardiovascular events, and COPD exacerbations. However, it is unclear if forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) differ in predictive value. Patients and Methods: Data from 16,485 participants in the Study to Understand Mortality and Morbidity (SUMMIT) in COPD were analyzed. Patients were grouped into quintiles for each lung function parameter (FEV1 %predicted, FVC %predicted, FEV1/FVC). The four highest quintiles (Q2–Q5) were compared to the lowest (Q1) to assess their relationship with all-cause mortality, cardiovascular events, and moderate-to-severe and severe exacerbations. Cox-regression was used, adjusted for age, sex, ethnicity, body-mass index, smoking status, previous exacerbations, cardiovascular disease, treatment, and modified Medical Research Council dyspnea score. Results: Compared to Q1 (<53.5% FEV predicted), increasing FEV quintiles (Q2 53.5–457.5% 1 1 predicted, Q3 57.5–461.6% predicted, Q4 61.6–465.8% predicted, and Q5 ≥65.8%) were all associated with significantly decreased all-cause mortality (20% (4–34%), 28% (13–40%), 23% (7–36%), and 30% (15–42%) risk reduction, respectively). In contrast, a significant risk reduction (21% (4–35%)) was seen only between Q1 and Q5 quintiles of FVC. Neither FEV1 nor FVC was associated with cardiovascular risk. Increased FEV1 and FEV1/FVC quintiles were also associated with the reduction of moderate-to-severe and severe exacerbations while, surprisingly, the highest FVC quintile was related to the heightened exacerbation risk (28% (8–52%) risk increase). Conclusion: Our results suggest that FEV1 is a stronger predictor for all-cause mortality than FVC in moderate COPD patients with heightened cardiovascular risk and that subjects with moderate COPD have very different risks.

AB - Purpose: Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death worldwide. Impaired lung function is associated with heightened risk for death, cardiovascular events, and COPD exacerbations. However, it is unclear if forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) differ in predictive value. Patients and Methods: Data from 16,485 participants in the Study to Understand Mortality and Morbidity (SUMMIT) in COPD were analyzed. Patients were grouped into quintiles for each lung function parameter (FEV1 %predicted, FVC %predicted, FEV1/FVC). The four highest quintiles (Q2–Q5) were compared to the lowest (Q1) to assess their relationship with all-cause mortality, cardiovascular events, and moderate-to-severe and severe exacerbations. Cox-regression was used, adjusted for age, sex, ethnicity, body-mass index, smoking status, previous exacerbations, cardiovascular disease, treatment, and modified Medical Research Council dyspnea score. Results: Compared to Q1 (<53.5% FEV predicted), increasing FEV quintiles (Q2 53.5–457.5% 1 1 predicted, Q3 57.5–461.6% predicted, Q4 61.6–465.8% predicted, and Q5 ≥65.8%) were all associated with significantly decreased all-cause mortality (20% (4–34%), 28% (13–40%), 23% (7–36%), and 30% (15–42%) risk reduction, respectively). In contrast, a significant risk reduction (21% (4–35%)) was seen only between Q1 and Q5 quintiles of FVC. Neither FEV1 nor FVC was associated with cardiovascular risk. Increased FEV1 and FEV1/FVC quintiles were also associated with the reduction of moderate-to-severe and severe exacerbations while, surprisingly, the highest FVC quintile was related to the heightened exacerbation risk (28% (8–52%) risk increase). Conclusion: Our results suggest that FEV1 is a stronger predictor for all-cause mortality than FVC in moderate COPD patients with heightened cardiovascular risk and that subjects with moderate COPD have very different risks.

KW - Airflow limitation

KW - Cardiovascular risk

KW - Death rate

KW - Exacerbation

KW - Lung function

KW - Lung volumes

U2 - 10.2147/COPD.S242809

DO - 10.2147/COPD.S242809

M3 - Journal article

C2 - 32547001

AN - SCOPUS:85085279117

VL - 15

SP - 1135

EP - 1142

JO - International Journal of COPD

JF - International Journal of COPD

SN - 1178-2005

ER -

ID: 242565471