Gender Moderates Results of a Randomized Clinical Trial for the Khanya Intervention for Substance Use and ART Adherence in HIV Care in South Africa

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Gender Moderates Results of a Randomized Clinical Trial for the Khanya Intervention for Substance Use and ART Adherence in HIV Care in South Africa. / Belus, Jennifer M.; Joska, John A.; Bronsteyn, Yosef; Rose, Alexandra L.; Andersen, Lena S.; Regenauer, Kristen S.; Myers, Bronwyn; Hahn, Judith A.; Orrell, Catherine; Safren, Steve A.; Magidson, Jessica F.

In: AIDS and Behavior, Vol. 26, 2022, p. 3630–3641.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Belus, JM, Joska, JA, Bronsteyn, Y, Rose, AL, Andersen, LS, Regenauer, KS, Myers, B, Hahn, JA, Orrell, C, Safren, SA & Magidson, JF 2022, 'Gender Moderates Results of a Randomized Clinical Trial for the Khanya Intervention for Substance Use and ART Adherence in HIV Care in South Africa', AIDS and Behavior, vol. 26, pp. 3630–3641. https://doi.org/10.1007/s10461-022-03765-8

APA

Belus, J. M., Joska, J. A., Bronsteyn, Y., Rose, A. L., Andersen, L. S., Regenauer, K. S., Myers, B., Hahn, J. A., Orrell, C., Safren, S. A., & Magidson, J. F. (2022). Gender Moderates Results of a Randomized Clinical Trial for the Khanya Intervention for Substance Use and ART Adherence in HIV Care in South Africa. AIDS and Behavior, 26, 3630–3641. https://doi.org/10.1007/s10461-022-03765-8

Vancouver

Belus JM, Joska JA, Bronsteyn Y, Rose AL, Andersen LS, Regenauer KS et al. Gender Moderates Results of a Randomized Clinical Trial for the Khanya Intervention for Substance Use and ART Adherence in HIV Care in South Africa. AIDS and Behavior. 2022;26:3630–3641. https://doi.org/10.1007/s10461-022-03765-8

Author

Belus, Jennifer M. ; Joska, John A. ; Bronsteyn, Yosef ; Rose, Alexandra L. ; Andersen, Lena S. ; Regenauer, Kristen S. ; Myers, Bronwyn ; Hahn, Judith A. ; Orrell, Catherine ; Safren, Steve A. ; Magidson, Jessica F. / Gender Moderates Results of a Randomized Clinical Trial for the Khanya Intervention for Substance Use and ART Adherence in HIV Care in South Africa. In: AIDS and Behavior. 2022 ; Vol. 26. pp. 3630–3641.

Bibtex

@article{a01f3d6aa2184e9c999e9a909b8b0bde,
title = "Gender Moderates Results of a Randomized Clinical Trial for the Khanya Intervention for Substance Use and ART Adherence in HIV Care in South Africa",
abstract = "Little is known about gender effects of alcohol and drug use (AOD) among people living with HIV (PLWH) in resource-limited settings. Using multilevel models, we tested whether gender moderated the effect of Khanya, a cognitive-behavioral therapy-based intervention addressing antiretroviral (ART) adherence and AOD reduction. We enrolled 61 participants from HIV care and examined outcomes at 3- and 6-months compared to enhanced treatment as usual (ETAU). Gender significantly moderated the effect of Khanya on ART adherence (measured using electronically-monitored and biomarker-confirmed adherence), such that women in Khanya had significantly lower ART adherence compared to men in Khanya; no gender differences were found for AOD outcomes. Exploratory trajectory analyses showed men in Khanya and both genders in ETAU had significant reductions in at least one AOD outcome; women in Khanya did not. More research is needed to understand whether a gender lens can support behavioral interventions for PLWH with AOD. Trial registry ClinicalTrials.gov identifier: NCT03529409. Trial registered on May 18, 2018.",
keywords = "ART adherence, Substance use, Behavioral intervention, Gender differences, South Africa, INTIMATE PARTNER VIOLENCE, ALCOHOL-USE, CAPE-TOWN, DRINKING, NONADHERENCE, DISEASE, HEALTH, DRUGS",
author = "Belus, {Jennifer M.} and Joska, {John A.} and Yosef Bronsteyn and Rose, {Alexandra L.} and Andersen, {Lena S.} and Regenauer, {Kristen S.} and Bronwyn Myers and Hahn, {Judith A.} and Catherine Orrell and Safren, {Steve A.} and Magidson, {Jessica F.}",
year = "2022",
doi = "10.1007/s10461-022-03765-8",
language = "English",
volume = "26",
pages = "3630–3641",
journal = "AIDS & Behavior",
issn = "1090-7165",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Gender Moderates Results of a Randomized Clinical Trial for the Khanya Intervention for Substance Use and ART Adherence in HIV Care in South Africa

AU - Belus, Jennifer M.

AU - Joska, John A.

AU - Bronsteyn, Yosef

AU - Rose, Alexandra L.

AU - Andersen, Lena S.

AU - Regenauer, Kristen S.

AU - Myers, Bronwyn

AU - Hahn, Judith A.

AU - Orrell, Catherine

AU - Safren, Steve A.

AU - Magidson, Jessica F.

PY - 2022

Y1 - 2022

N2 - Little is known about gender effects of alcohol and drug use (AOD) among people living with HIV (PLWH) in resource-limited settings. Using multilevel models, we tested whether gender moderated the effect of Khanya, a cognitive-behavioral therapy-based intervention addressing antiretroviral (ART) adherence and AOD reduction. We enrolled 61 participants from HIV care and examined outcomes at 3- and 6-months compared to enhanced treatment as usual (ETAU). Gender significantly moderated the effect of Khanya on ART adherence (measured using electronically-monitored and biomarker-confirmed adherence), such that women in Khanya had significantly lower ART adherence compared to men in Khanya; no gender differences were found for AOD outcomes. Exploratory trajectory analyses showed men in Khanya and both genders in ETAU had significant reductions in at least one AOD outcome; women in Khanya did not. More research is needed to understand whether a gender lens can support behavioral interventions for PLWH with AOD. Trial registry ClinicalTrials.gov identifier: NCT03529409. Trial registered on May 18, 2018.

AB - Little is known about gender effects of alcohol and drug use (AOD) among people living with HIV (PLWH) in resource-limited settings. Using multilevel models, we tested whether gender moderated the effect of Khanya, a cognitive-behavioral therapy-based intervention addressing antiretroviral (ART) adherence and AOD reduction. We enrolled 61 participants from HIV care and examined outcomes at 3- and 6-months compared to enhanced treatment as usual (ETAU). Gender significantly moderated the effect of Khanya on ART adherence (measured using electronically-monitored and biomarker-confirmed adherence), such that women in Khanya had significantly lower ART adherence compared to men in Khanya; no gender differences were found for AOD outcomes. Exploratory trajectory analyses showed men in Khanya and both genders in ETAU had significant reductions in at least one AOD outcome; women in Khanya did not. More research is needed to understand whether a gender lens can support behavioral interventions for PLWH with AOD. Trial registry ClinicalTrials.gov identifier: NCT03529409. Trial registered on May 18, 2018.

KW - ART adherence

KW - Substance use

KW - Behavioral intervention

KW - Gender differences

KW - South Africa

KW - INTIMATE PARTNER VIOLENCE

KW - ALCOHOL-USE

KW - CAPE-TOWN

KW - DRINKING

KW - NONADHERENCE

KW - DISEASE

KW - HEALTH

KW - DRUGS

U2 - 10.1007/s10461-022-03765-8

DO - 10.1007/s10461-022-03765-8

M3 - Journal article

C2 - 35895150

VL - 26

SP - 3630

EP - 3641

JO - AIDS & Behavior

JF - AIDS & Behavior

SN - 1090-7165

ER -

ID: 315456055