Genetic risk scores link body fat distribution with specific cardiometabolic profiles
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Genetic risk scores link body fat distribution with specific cardiometabolic profiles. / Svendstrup, Mathilde; Sandholt, Camilla H; Andersson Galijatovic, Ehm Astrid; Linneberg, Allan; Jørgensen, Torben; Sørensen, Thorkild I A; Pedersen, Oluf; Grarup, Niels; Hansen, Torben; Vestergaard, Henrik.
In: Obesity, Vol. 24, No. 8, 08.2016, p. 1778-1785.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Genetic risk scores link body fat distribution with specific cardiometabolic profiles
AU - Svendstrup, Mathilde
AU - Sandholt, Camilla H
AU - Andersson Galijatovic, Ehm Astrid
AU - Linneberg, Allan
AU - Jørgensen, Torben
AU - Sørensen, Thorkild I A
AU - Pedersen, Oluf
AU - Grarup, Niels
AU - Hansen, Torben
AU - Vestergaard, Henrik
N1 - © 2016 The Obesity Society.
PY - 2016/8
Y1 - 2016/8
N2 - OBJECTIVE: Forty-nine known single nucleotide polymorphisms (SNPs) associating with body mass index (BMI)-adjusted waist-hip-ratio (WHR) (WHRadjBMI) were recently suggested to cluster into three groups with different associations to cardiometabolic traits. Genetic risk scores of the clusters on the risk of incident diabetes and associations with detailed cardiometabolic phenotypes were tested.METHODS: In a prospective study of 6,121 Inter99 individuals, the risk of incident diabetes using Cox proportional hazards regression was evaluated. Using linear regession, the associations between genetic risk scores and anthropometry and blood samples at fasting and during an oral glucose tolerance test were tested. Analyses were adjusted for age, sex, and BMI.RESULTS: Cluster 1 associated with an increased risk of diabetes (HR = 1.05, P = 2.74 × 10(-) (4) ) and with a poor metabolic profile, including fasting serum triglyceride (β = 0.98% mmol/L, P = 3.33 × 10(-) (8) ) and Matsuda index (β = -0.74%, P = 1.29 × 10(-) (4) ). No similar associations for Clusters 2 and 3 were found. The three clusters showed different patterns of association with waist circumference, hip circumference, and height.CONCLUSIONS: Our results suggest that the 49 WHRadjBMI-associated SNPs affect metabolic health differently depending on the cluster of SNPs. The clusters further associate differently with anthropometric measures.
AB - OBJECTIVE: Forty-nine known single nucleotide polymorphisms (SNPs) associating with body mass index (BMI)-adjusted waist-hip-ratio (WHR) (WHRadjBMI) were recently suggested to cluster into three groups with different associations to cardiometabolic traits. Genetic risk scores of the clusters on the risk of incident diabetes and associations with detailed cardiometabolic phenotypes were tested.METHODS: In a prospective study of 6,121 Inter99 individuals, the risk of incident diabetes using Cox proportional hazards regression was evaluated. Using linear regession, the associations between genetic risk scores and anthropometry and blood samples at fasting and during an oral glucose tolerance test were tested. Analyses were adjusted for age, sex, and BMI.RESULTS: Cluster 1 associated with an increased risk of diabetes (HR = 1.05, P = 2.74 × 10(-) (4) ) and with a poor metabolic profile, including fasting serum triglyceride (β = 0.98% mmol/L, P = 3.33 × 10(-) (8) ) and Matsuda index (β = -0.74%, P = 1.29 × 10(-) (4) ). No similar associations for Clusters 2 and 3 were found. The three clusters showed different patterns of association with waist circumference, hip circumference, and height.CONCLUSIONS: Our results suggest that the 49 WHRadjBMI-associated SNPs affect metabolic health differently depending on the cluster of SNPs. The clusters further associate differently with anthropometric measures.
KW - Journal Article
U2 - 10.1002/oby.21473
DO - 10.1002/oby.21473
M3 - Journal article
C2 - 27311925
VL - 24
SP - 1778
EP - 1785
JO - Obesity
JF - Obesity
SN - 1930-7381
IS - 8
ER -
ID: 165810030