Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index
Research output: Contribution to journal › Journal article › Research › peer-review
Cigarette smoking is associated with lower body mass index (BMI), and a commonly cited reason for unwillingness to quit smoking is a concern about weight gain. Common variation in the CHRNA5-CHRNA3-CHRNB4 gene region (chromosome 15q25) is robustly associated with smoking quantity in smokers, but its association with BMI is unknown. We hypothesized that genotype would accurately reflect smoking exposure and that, if smoking were causally related to weight, it would be associated with BMI in smokers, but not in never smokers.
Original language | English |
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Journal | International Journal of Epidemiology |
Volume | 40 |
Issue number | 6 |
Pages (from-to) | 1617-28 |
Number of pages | 12 |
ISSN | 0300-5771 |
DOIs | |
Publication status | Published - 2011 |
ID: 40207895