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Genome-Wide Association Study of Circulating Interleukin 6 Levels Identifies Novel Loci. / Ahluwalia, Tarunveer S; Prins, Bram P; Abdollahi, Mohammadreza; Armstrong, Nicola J; Aslibekyan, Stella; Bain, Lisa; Jefferis, Barbara; Baumert, Jens; Beekman, Marian; Ben-Shlomo, Yoav; Bis, Joshua C; Mitchell, Braxton D; de Geus, Eco; Delgado, Graciela E; Marek, Diana; Eriksson, Joel; Kajantie, Eero; Kanoni, Stavroula; Kemp, John P; Lu, Chen; Marioni, Riccardo E; McLachlan, Stela; Milaneschi, Yuri; Nolte, Ilja M; Petrelis, Alexandros M; Porcu, Eleonora; Sabater-Lleal, Maria; Naderi, Elnaz; Seppälä, Ilkka; Shah, Tina; Singhal, Gaurav; Standl, Marie; Teumer, Alexander; Thalamuthu, Anbupalam; Thiering, Elisabeth; Trompet, Stella; Ballantyne, Christie M; Benjamin, Emelia J; Casas, Juan P; Toben, Catherine; Dedoussis, George; Deelen, Joris; Durda, Peter; Engmann, Jorgen; Feitosa, Mary F; Grallert, Harald; Hammarstedt, Ann; Jess, Tine; Rossing, Peter; Sørensen, Thorkild I A; CHARGE Inflammation Working Group.
In:
Human Molecular Genetics, Vol. 30, No. 5, 2021, p. 393–409.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Ahluwalia, TS, Prins, BP, Abdollahi, M, Armstrong, NJ, Aslibekyan, S, Bain, L, Jefferis, B, Baumert, J, Beekman, M, Ben-Shlomo, Y, Bis, JC, Mitchell, BD, de Geus, E, Delgado, GE, Marek, D, Eriksson, J, Kajantie, E, Kanoni, S, Kemp, JP, Lu, C, Marioni, RE, McLachlan, S, Milaneschi, Y, Nolte, IM, Petrelis, AM, Porcu, E, Sabater-Lleal, M, Naderi, E, Seppälä, I, Shah, T, Singhal, G, Standl, M, Teumer, A, Thalamuthu, A, Thiering, E, Trompet, S, Ballantyne, CM, Benjamin, EJ, Casas, JP, Toben, C, Dedoussis, G, Deelen, J, Durda, P, Engmann, J, Feitosa, MF, Grallert, H, Hammarstedt, A, Jess, T
, Rossing, P, Sørensen, TIA & CHARGE Inflammation Working Group 2021, '
Genome-Wide Association Study of Circulating Interleukin 6 Levels Identifies Novel Loci',
Human Molecular Genetics, vol. 30, no. 5, pp. 393–409.
https://doi.org/10.1093/hmg/ddab023APA
Ahluwalia, T. S., Prins, B. P., Abdollahi, M., Armstrong, N. J., Aslibekyan, S., Bain, L., Jefferis, B., Baumert, J., Beekman, M., Ben-Shlomo, Y., Bis, J. C., Mitchell, B. D., de Geus, E., Delgado, G. E., Marek, D., Eriksson, J., Kajantie, E., Kanoni, S., Kemp, J. P., ... CHARGE Inflammation Working Group (2021).
Genome-Wide Association Study of Circulating Interleukin 6 Levels Identifies Novel Loci.
Human Molecular Genetics,
30(5), 393–409.
https://doi.org/10.1093/hmg/ddab023Vancouver
Ahluwalia TS, Prins BP, Abdollahi M, Armstrong NJ, Aslibekyan S, Bain L et al.
Genome-Wide Association Study of Circulating Interleukin 6 Levels Identifies Novel Loci.
Human Molecular Genetics. 2021;30(5):393–409.
https://doi.org/10.1093/hmg/ddab023Author
Ahluwalia, Tarunveer S ; Prins, Bram P ; Abdollahi, Mohammadreza ; Armstrong, Nicola J ; Aslibekyan, Stella ; Bain, Lisa ; Jefferis, Barbara ; Baumert, Jens ; Beekman, Marian ; Ben-Shlomo, Yoav ; Bis, Joshua C ; Mitchell, Braxton D ; de Geus, Eco ; Delgado, Graciela E ; Marek, Diana ; Eriksson, Joel ; Kajantie, Eero ; Kanoni, Stavroula ; Kemp, John P ; Lu, Chen ; Marioni, Riccardo E ; McLachlan, Stela ; Milaneschi, Yuri ; Nolte, Ilja M ; Petrelis, Alexandros M ; Porcu, Eleonora ; Sabater-Lleal, Maria ; Naderi, Elnaz ; Seppälä, Ilkka ; Shah, Tina ; Singhal, Gaurav ; Standl, Marie ; Teumer, Alexander ; Thalamuthu, Anbupalam ; Thiering, Elisabeth ; Trompet, Stella ; Ballantyne, Christie M ; Benjamin, Emelia J ; Casas, Juan P ; Toben, Catherine ; Dedoussis, George ; Deelen, Joris ; Durda, Peter ; Engmann, Jorgen ; Feitosa, Mary F ; Grallert, Harald ; Hammarstedt, Ann ; Jess, Tine ; Rossing, Peter ; Sørensen, Thorkild I A ; CHARGE Inflammation Working Group. / Genome-Wide Association Study of Circulating Interleukin 6 Levels Identifies Novel Loci. In: Human Molecular Genetics. 2021 ; Vol. 30, No. 5. pp. 393–409.
Bibtex
@article{5ed348680ae3415796348ab4ffdd01d7,
title = "Genome-Wide Association Study of Circulating Interleukin 6 Levels Identifies Novel Loci",
abstract = "Interleukin-6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. We conducted a two-staged, discovery, and replication meta genome-wide association study (GWAS) of circulating serum IL-6 levels comprising up to 67 428 (ndiscovery = 52 654 and nreplication = 14 774) individuals of European ancestry. The inverse variance fixed-effects based discovery meta-analysis, followed by replication led to the identification of two independent loci, IL1F10/IL1RN rs6734238 on Chromosome (Chr) 2q14, (pcombined = 1.8 × 10-11), HLA-DRB1/DRB5 rs660895 on Chr6p21 (pcombined = 1.5 × 10-10) in the combined meta-analyses of all samples. We also replicated the IL6R rs4537545 locus on Chr1q21 (pcombined = 1.2 × 10-122). Our study identifies novel loci for circulating IL-6 levels uncovering new immunological and inflammatory pathways that may influence IL-6 pathobiology.",
author = "Ahluwalia, {Tarunveer S} and Prins, {Bram P} and Mohammadreza Abdollahi and Armstrong, {Nicola J} and Stella Aslibekyan and Lisa Bain and Barbara Jefferis and Jens Baumert and Marian Beekman and Yoav Ben-Shlomo and Bis, {Joshua C} and Mitchell, {Braxton D} and {de Geus}, Eco and Delgado, {Graciela E} and Diana Marek and Joel Eriksson and Eero Kajantie and Stavroula Kanoni and Kemp, {John P} and Chen Lu and Marioni, {Riccardo E} and Stela McLachlan and Yuri Milaneschi and Nolte, {Ilja M} and Petrelis, {Alexandros M} and Eleonora Porcu and Maria Sabater-Lleal and Elnaz Naderi and Ilkka Sepp{\"a}l{\"a} and Tina Shah and Gaurav Singhal and Marie Standl and Alexander Teumer and Anbupalam Thalamuthu and Elisabeth Thiering and Stella Trompet and Ballantyne, {Christie M} and Benjamin, {Emelia J} and Casas, {Juan P} and Catherine Toben and George Dedoussis and Joris Deelen and Peter Durda and Jorgen Engmann and Feitosa, {Mary F} and Harald Grallert and Ann Hammarstedt and Tine Jess and Peter Rossing and S{\o}rensen, {Thorkild I A} and {CHARGE Inflammation Working Group}",
note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press.",
year = "2021",
doi = "10.1093/hmg/ddab023",
language = "English",
volume = "30",
pages = "393–409",
journal = "Human Molecular Genetics",
issn = "0964-6906",
publisher = "Oxford University Press",
number = "5",
}
RIS
TY - JOUR
T1 - Genome-Wide Association Study of Circulating Interleukin 6 Levels Identifies Novel Loci
AU - Ahluwalia, Tarunveer S
AU - Prins, Bram P
AU - Abdollahi, Mohammadreza
AU - Armstrong, Nicola J
AU - Aslibekyan, Stella
AU - Bain, Lisa
AU - Jefferis, Barbara
AU - Baumert, Jens
AU - Beekman, Marian
AU - Ben-Shlomo, Yoav
AU - Bis, Joshua C
AU - Mitchell, Braxton D
AU - de Geus, Eco
AU - Delgado, Graciela E
AU - Marek, Diana
AU - Eriksson, Joel
AU - Kajantie, Eero
AU - Kanoni, Stavroula
AU - Kemp, John P
AU - Lu, Chen
AU - Marioni, Riccardo E
AU - McLachlan, Stela
AU - Milaneschi, Yuri
AU - Nolte, Ilja M
AU - Petrelis, Alexandros M
AU - Porcu, Eleonora
AU - Sabater-Lleal, Maria
AU - Naderi, Elnaz
AU - Seppälä, Ilkka
AU - Shah, Tina
AU - Singhal, Gaurav
AU - Standl, Marie
AU - Teumer, Alexander
AU - Thalamuthu, Anbupalam
AU - Thiering, Elisabeth
AU - Trompet, Stella
AU - Ballantyne, Christie M
AU - Benjamin, Emelia J
AU - Casas, Juan P
AU - Toben, Catherine
AU - Dedoussis, George
AU - Deelen, Joris
AU - Durda, Peter
AU - Engmann, Jorgen
AU - Feitosa, Mary F
AU - Grallert, Harald
AU - Hammarstedt, Ann
AU - Jess, Tine
AU - Rossing, Peter
AU - Sørensen, Thorkild I A
AU - CHARGE Inflammation Working Group
N1 - © The Author(s) 2021. Published by Oxford University Press.
PY - 2021
Y1 - 2021
N2 - Interleukin-6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. We conducted a two-staged, discovery, and replication meta genome-wide association study (GWAS) of circulating serum IL-6 levels comprising up to 67 428 (ndiscovery = 52 654 and nreplication = 14 774) individuals of European ancestry. The inverse variance fixed-effects based discovery meta-analysis, followed by replication led to the identification of two independent loci, IL1F10/IL1RN rs6734238 on Chromosome (Chr) 2q14, (pcombined = 1.8 × 10-11), HLA-DRB1/DRB5 rs660895 on Chr6p21 (pcombined = 1.5 × 10-10) in the combined meta-analyses of all samples. We also replicated the IL6R rs4537545 locus on Chr1q21 (pcombined = 1.2 × 10-122). Our study identifies novel loci for circulating IL-6 levels uncovering new immunological and inflammatory pathways that may influence IL-6 pathobiology.
AB - Interleukin-6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. We conducted a two-staged, discovery, and replication meta genome-wide association study (GWAS) of circulating serum IL-6 levels comprising up to 67 428 (ndiscovery = 52 654 and nreplication = 14 774) individuals of European ancestry. The inverse variance fixed-effects based discovery meta-analysis, followed by replication led to the identification of two independent loci, IL1F10/IL1RN rs6734238 on Chromosome (Chr) 2q14, (pcombined = 1.8 × 10-11), HLA-DRB1/DRB5 rs660895 on Chr6p21 (pcombined = 1.5 × 10-10) in the combined meta-analyses of all samples. We also replicated the IL6R rs4537545 locus on Chr1q21 (pcombined = 1.2 × 10-122). Our study identifies novel loci for circulating IL-6 levels uncovering new immunological and inflammatory pathways that may influence IL-6 pathobiology.
U2 - 10.1093/hmg/ddab023
DO - 10.1093/hmg/ddab023
M3 - Journal article
C2 - 33517400
VL - 30
SP - 393
EP - 409
JO - Human Molecular Genetics
JF - Human Molecular Genetics
SN - 0964-6906
IS - 5
ER -
