Global trends of pulmonary infections with nontuberculous mycobacteria: a systematic review
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Global trends of pulmonary infections with nontuberculous mycobacteria : a systematic review. / Dahl, Victor Naestholt; Molhave, Martin; Floe, Andreas; van Ingen, Jakko; Schon, Thomas; Lillebaek, Troels; Andersen, Aase Bengaard; Wejse, Christian.
In: International Journal of Infectious Diseases, Vol. 125, 2022, p. 120-131.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Global trends of pulmonary infections with nontuberculous mycobacteria
T2 - a systematic review
AU - Dahl, Victor Naestholt
AU - Molhave, Martin
AU - Floe, Andreas
AU - van Ingen, Jakko
AU - Schon, Thomas
AU - Lillebaek, Troels
AU - Andersen, Aase Bengaard
AU - Wejse, Christian
PY - 2022
Y1 - 2022
N2 - Objectives: To describe the global trends of pulmonary nontuberculous mycobacteria (NTM) infection and disease.Methods: A systematic review of studies including culture-based NTM data over time. Studies reporting on pulmonary NTM infection and/or disease were included. Information on the use of guideline-based criteria for disease were collected, in which, infection is defined as the absence of symptoms and radiological findings compatible with NTM pulmonary disease. The trends of change for incidence/prevalence were evaluated using linear regressions, and the corresponding pooled estimates were calculated.Results: Most studies reported increasing pulmonary NTM infection (82.1%) and disease (66.7%) trends. The overall annual rate of change for NTM infection and disease per 10 0,000 persons/year was 4.0% (95% confidence interval [CI]: 3.2-4.8) and 4.1% (95% CI: 3.2-5.0), respectively. For absolute numbers of NTM infection and disease, the overall annual change was 2.0 (95% CI: 1.6-2.3) and 0.5 (95% CI: 0.3-0.7), respectively. An increasing trend was also seen for Mycobacterium avium complex infection (n = 15/19, 78.9%) and disease (n = 10/12, 83.9%) and for Mycobacterium abscessus complex (n = 15/23, 65.2%) infection (n = 11/17, 64.7%) but less so for disease (n = 2/8, 25.0%).Conclusion: Our data indicate an overall increase in NTM worldwide for both infection and disease. The explanation to this phenomenon warrants further investigation.(c) 2022 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
AB - Objectives: To describe the global trends of pulmonary nontuberculous mycobacteria (NTM) infection and disease.Methods: A systematic review of studies including culture-based NTM data over time. Studies reporting on pulmonary NTM infection and/or disease were included. Information on the use of guideline-based criteria for disease were collected, in which, infection is defined as the absence of symptoms and radiological findings compatible with NTM pulmonary disease. The trends of change for incidence/prevalence were evaluated using linear regressions, and the corresponding pooled estimates were calculated.Results: Most studies reported increasing pulmonary NTM infection (82.1%) and disease (66.7%) trends. The overall annual rate of change for NTM infection and disease per 10 0,000 persons/year was 4.0% (95% confidence interval [CI]: 3.2-4.8) and 4.1% (95% CI: 3.2-5.0), respectively. For absolute numbers of NTM infection and disease, the overall annual change was 2.0 (95% CI: 1.6-2.3) and 0.5 (95% CI: 0.3-0.7), respectively. An increasing trend was also seen for Mycobacterium avium complex infection (n = 15/19, 78.9%) and disease (n = 10/12, 83.9%) and for Mycobacterium abscessus complex (n = 15/23, 65.2%) infection (n = 11/17, 64.7%) but less so for disease (n = 2/8, 25.0%).Conclusion: Our data indicate an overall increase in NTM worldwide for both infection and disease. The explanation to this phenomenon warrants further investigation.(c) 2022 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
KW - Nontuberculous mycobacteria
KW - Respiratory infections
KW - Incidence
KW - Systematic review
KW - Chronic lung disease
KW - AVIUM COMPLEX DISEASE
KW - LUNG-DISEASE
KW - CYSTIC-FIBROSIS
KW - UNITED-STATES
KW - GEOGRAPHIC-DISTRIBUTION
KW - CLINICAL-RELEVANCE
KW - PREVALENCE
KW - EPIDEMIOLOGY
KW - TAIWAN
KW - SUSCEPTIBILITY
U2 - 10.1016/j.ijid.2022.10.013
DO - 10.1016/j.ijid.2022.10.013
M3 - Review
C2 - 36244600
VL - 125
SP - 120
EP - 131
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
SN - 1201-9712
ER -
ID: 344813501